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Lcor ligand dependent nuclear receptor corepressor [ Mus musculus (house mouse) ]

Gene ID: 212391, updated on 21-Apr-2024

Summary

Official Symbol
Lcorprovided by MGI
Official Full Name
ligand dependent nuclear receptor corepressorprovided by MGI
Primary source
MGI:MGI:2443930
See related
Ensembl:ENSMUSG00000025019 AllianceGenome:MGI:2443930
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mlr2; Gm340; mKIAA1795; 3110023F06Rik; A630025C20Rik
Summary
Enables chromatin binding activity. Involved in positive regulation of histone H3-K27 trimethylation. Acts upstream of or within negative regulation of transcription by RNA polymerase II and transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including 1st branchial arch; genitourinary system; long bone epiphysis; nervous system; and sensory organ. Orthologous to human LCOR (ligand dependent nuclear receptor corepressor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 2.8), placenta adult (RPKM 2.7) and 28 other tissues See more
Orthologs
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Genomic context

Location:
19 C3; 19 34.97 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (41471121..41584600)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (41482682..41596161)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_46153 Neighboring gene predicted gene, 33951 Neighboring gene STARR-positive B cell enhancer ABC_E7655 Neighboring gene STARR-positive B cell enhancer mm9_chr19:41556663-41556964 Neighboring gene developmental pluripotency associated 2 pseudogene Neighboring gene mortality factor 4 like 1B Neighboring gene microRNA 8091 Neighboring gene predicted gene, 52407 Neighboring gene slit guidance ligand 1 Neighboring gene STARR-seq mESC enhancer starr_46158 Neighboring gene predicted gene, 34116

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
enables histone methyltransferase binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-specific protease binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
ligand-dependent corepressor
Names
Mblk1-related protein-2
mblk1-related protein 2
transcription factor MLR2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370767.1NP_001357696.1  ligand-dependent corepressor isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC112271, AC132303
    Consensus CDS
    CCDS89392.1
    UniProtKB/TrEMBL
    A0A571BE94, A0A571BF12
    Related
    ENSMUSP00000158715.2, ENSMUST00000238398.2
    Conserved Domains (3) summary
    PTZ00441
    Location:726959
    PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
    pfam05109
    Location:558823
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam15090
    Location:12471694
    DUF4553; Domain of unknown function (DUF4553)
  2. NM_172154.4NP_742166.1  ligand-dependent corepressor isoform 2

    See identical proteins and their annotated locations for NP_742166.1

    Status: VALIDATED

    Source sequence(s)
    AC132303
    Consensus CDS
    CCDS29810.1
    UniProtKB/Swiss-Prot
    Q3U302, Q5CZW7, Q6ZPI3, Q80VA8, Q8BGT2, Q8C9Q0
    UniProtKB/TrEMBL
    A0A494B9R4, A4FTY7
    Related
    ENSMUSP00000126441.2, ENSMUST00000163929.2
    Conserved Domains (1) summary
    pfam05225
    Location:352395
    HTH_psq; helix-turn-helix, Psq domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    41471121..41584600
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)