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Zfp748 zinc finger protein 748 [ Mus musculus (house mouse) ]

Gene ID: 212276, updated on 8-Feb-2024

Summary

Official Symbol
Zfp748provided by MGI
Official Full Name
zinc finger protein 748provided by MGI
Primary source
MGI:MGI:1916455
See related
Ensembl:ENSMUSG00000095432 AllianceGenome:MGI:1916455
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KRAB-O; Zfp208; mszf54; Rslcan20/21
Summary
Enables protein-macromolecule adaptor activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in gonad; liver; and mesonephros. Orthologous to several human genes including ZNF107 (zinc finger protein 107); ZNF208 (zinc finger protein 208); and ZNF43 (zinc finger protein 43). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 2.3), CNS E18 (RPKM 2.2) and 24 other tissues See more
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Genomic context

Location:
13 B3; 13 34.54 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (67686758..67701257, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (67538641..67553152, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 458 pseudogene Neighboring gene zinc finger protein 87 Neighboring gene STARR-positive B cell enhancer ABC_E4076 Neighboring gene RIKEN cDNA 9430065F17 gene Neighboring gene STARR-positive B cell enhancer ABC_E9881 Neighboring gene zinc finger protein 729b Neighboring gene STARR-positive B cell enhancer ABC_E4077

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

Markers

Clone Names

  • KIAA4236, MGC60742, mKIAA423, 2610014M12Rik

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
zinc finger protein 748
Names
KRAB zinc finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001035231.4NP_001030308.1  zinc finger protein 748 isoform 1

    See identical proteins and their annotated locations for NP_001030308.1

    Status: VALIDATED

    Source sequence(s)
    CT573016
    Consensus CDS
    CCDS59589.1
    UniProtKB/TrEMBL
    Q7TPL6
    Related
    ENSMUSP00000137928.2, ENSMUST00000181892.9
    Conserved Domains (5) summary
    smart00349
    Location:563
    KRAB; krueppel associated box
    COG5048
    Location:442875
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:782802
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:544
    KRAB; KRAB box
    pfam13465
    Location:461483
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001401856.1NP_001388785.1  zinc finger protein 748 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT573016
    UniProtKB/TrEMBL
    Q8BTB4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    67686758..67701257 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_183145.2: Suppressed sequence

    Description
    NM_183145.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.