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Rln3 relaxin 3 [ Mus musculus (house mouse) ]

Gene ID: 212108, updated on 27-Nov-2024

Summary

Official Symbol
Rln3provided by MGI
Official Full Name
relaxin 3provided by MGI
Primary source
MGI:MGI:2158015
See related
Ensembl:ENSMUSG00000045232 AllianceGenome:MGI:2158015
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
M3; insl7
Summary
Predicted to enable G protein-coupled receptor binding activity. Predicted to be involved in signal transduction. Predicted to be located in extracellular region. Is expressed in several structures, including Harderian gland; alimentary system; brain; genitourinary system; and hemolymphoid system gland. Orthologous to human RLN3 (relaxin 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in spleen adult (RPKM 3.0), thymus adult (RPKM 2.9) and 13 other tissues See more
Orthologs
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Genomic context

See Rln3 in Genome Data Viewer
Location:
8 C2; 8 40.26 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (84769696..84771608, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (84043067..84044979, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene paralemmin 3 Neighboring gene predicted gene, 53445 Neighboring gene interleukin 27 receptor, alpha Neighboring gene STARR-seq mESC enhancer starr_22106 Neighboring gene STARR-positive B cell enhancer ABC_E73 Neighboring gene STARR-positive B cell enhancer ABC_E5024 Neighboring gene predicted gene 10643 Neighboring gene regulatory factor X, 1 (influences HLA class II expression) Neighboring gene microRNA 709

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (4)  1 citation

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G protein-coupled receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
relaxin-3
Names
insulin-like 7
insulin-like peptide 7
insulin-like peptide INSL7
prorelaxin M3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173184.1NP_775276.1  relaxin-3 precursor

    See identical proteins and their annotated locations for NP_775276.1

    Status: PROVISIONAL

    Source sequence(s)
    AB076565
    Consensus CDS
    CCDS22466.1
    UniProtKB/Swiss-Prot
    Q8CHK2
    Related
    ENSMUSP00000051392.4, ENSMUST00000061923.5
    Conserved Domains (1) summary
    cd04365
    Location:30141
    IlGF_relaxin_like; IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4), ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    84769696..84771608 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)