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Hk3 hexokinase 3 [ Mus musculus (house mouse) ]

Gene ID: 212032, updated on 27-Nov-2024

Summary

Official Symbol
Hk3provided by MGI
Official Full Name
hexokinase 3provided by MGI
Primary source
MGI:MGI:2670962
See related
Ensembl:ENSMUSG00000025877 AllianceGenome:MGI:2670962
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HK III; HK-III
Summary
Predicted to enable enzyme binding activity; hexokinase activity; and hormone binding activity. Predicted to be involved in several processes, including fructose 6-phosphate metabolic process; glycolytic process; and negative regulation of hydrogen peroxide-mediated programmed cell death. Located in mitochondrion. Is expressed in several structures, including adrenal gland; alimentary system; central nervous system; musculoskeletal system; and olfactory epithelium. Orthologous to human HK3 (hexokinase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in mammary gland adult (RPKM 8.5), spleen adult (RPKM 6.6) and 21 other tissues See more
Orthologs
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Genomic context

See Hk3 in Genome Data Viewer
Location:
13 B1; 13 29.8 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (55153798..55169233, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (55005985..55021475, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930526F13 gene Neighboring gene predicted gene, 31313 Neighboring gene unc-5 netrin receptor A Neighboring gene ubiquitin interaction motif containing 1 Neighboring gene STARR-seq mESC enhancer starr_34599 Neighboring gene ribosomal protein L29 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1877 Neighboring gene zinc finger protein 346 Neighboring gene STARR-positive B cell enhancer mm9_chr13:55226322-55226622 Neighboring gene predicted gene, 46415

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC143940

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables D-glucose binding IEA
Inferred from Electronic Annotation
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables fructokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables fructokinase activity ISO
Inferred from Sequence Orthology
more info
 
enables fructokinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables glucokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glucokinase activity ISO
Inferred from Sequence Orthology
more info
 
enables glucokinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables hexokinase activity ISO
Inferred from Sequence Orthology
more info
 
enables hormone binding ISO
Inferred from Sequence Orthology
more info
 
enables mannokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in carbohydrate phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in fructose 6-phosphate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in fructose 6-phosphate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in glucose 6-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glucose 6-phosphate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose 6-phosphate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
 
involved_in hexose metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular glucose homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of hydrogen peroxide-mediated programmed cell death ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
hexokinase-3
Names
hexokinase type III
hexokinase-C
NP_001028417.1
NP_001193319.1
NP_001193320.1
NP_001193321.1
XP_036013853.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033245.4NP_001028417.1  hexokinase-3 isoform 1

    See identical proteins and their annotated locations for NP_001028417.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC154610, AK171580, BI133441
    Consensus CDS
    CCDS26538.1
    UniProtKB/Swiss-Prot
    Q3TAX6, Q3TRM8, Q3UDP1, Q3UEA4
    UniProtKB/TrEMBL
    Q3TBG9, Q3TQE0, Q3TVQ4
    Related
    ENSMUSP00000051215.7, ENSMUST00000052949.13
    Conserved Domains (3) summary
    PLN02914
    Location:70469
    PLN02914; hexokinase
    pfam00349
    Location:480672
    Hexokinase_1
    pfam03727
    Location:678912
    Hexokinase_2
  2. NM_001206390.1NP_001193319.1  hexokinase-3 isoform 1

    See identical proteins and their annotated locations for NP_001193319.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC154610
    Consensus CDS
    CCDS26538.1
    UniProtKB/Swiss-Prot
    Q3TAX6, Q3TRM8, Q3UDP1, Q3UEA4
    UniProtKB/TrEMBL
    Q3TBG9, Q3TQE0, Q3TVQ4
    Related
    ENSMUSP00000123233.2, ENSMUST00000126234.8
    Conserved Domains (3) summary
    PLN02914
    Location:70469
    PLN02914; hexokinase
    pfam00349
    Location:480672
    Hexokinase_1
    pfam03727
    Location:678912
    Hexokinase_2
  3. NM_001206391.1NP_001193320.1  hexokinase-3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC154610
    Consensus CDS
    CCDS56884.1
    UniProtKB/TrEMBL
    E9Q8S8, Q08EC2
    Related
    ENSMUSP00000116717.2, ENSMUST00000123097.8
    Conserved Domains (3) summary
    PTZ00107
    Location:429868
    PTZ00107; hexokinase; Provisional
    pfam00349
    Location:435627
    Hexokinase_1; Hexokinase
    pfam03727
    Location:633867
    Hexokinase_2; Hexokinase
  4. NM_001206392.1NP_001193321.1  hexokinase-3 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC154610
    Consensus CDS
    CCDS56883.1
    UniProtKB/TrEMBL
    E9Q3Z4, Q3TCB2
    Related
    ENSMUSP00000115227.2, ENSMUST00000153665.8
    Conserved Domains (3) summary
    PLN02914
    Location:15414
    PLN02914; hexokinase
    pfam00349
    Location:425617
    Hexokinase_1
    pfam03727
    Location:623857
    Hexokinase_2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    55153798..55169233 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157960.1XP_036013853.1  hexokinase-3 isoform X1

    UniProtKB/TrEMBL
    E9Q3Z4, Q3TCB2
    Conserved Domains (3) summary
    PLN02914
    Location:15414
    PLN02914; hexokinase
    pfam00349
    Location:425617
    Hexokinase_1
    pfam03727
    Location:623857
    Hexokinase_2

RNA

  1. XR_004938008.1 RNA Sequence

    Related
    ENSMUST00000132309.8