U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tifa TRAF-interacting protein with forkhead-associated domain [ Mus musculus (house mouse) ]

Gene ID: 211550, updated on 11-Apr-2024

Summary

Official Symbol
Tifaprovided by MGI
Official Full Name
TRAF-interacting protein with forkhead-associated domainprovided by MGI
Primary source
MGI:MGI:2182965
See related
Ensembl:ENSMUSG00000046688 AllianceGenome:MGI:2182965
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
T2bp
Summary
Acts upstream of or within I-kappaB kinase/NF-kappaB signaling. Predicted to be active in cytoplasm. Is expressed in several structures, including brain ventricular layer; cerebral cortex subventricular zone; gut; liver; and trigeminal ganglion. Orthologous to human TIFA (TRAF interacting protein with forkhead associated domain). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 20.9), colon adult (RPKM 4.1) and 12 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Tifa in Genome Data Viewer
Location:
3 G2; 3 56.54 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (127582524..127592043)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (127788875..127798394)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene neurogenin 2 Neighboring gene alpha-kinase 1 Neighboring gene STARR-seq mESC enhancer starr_08957 Neighboring gene VISTA enhancer mm1549 Neighboring gene ribosomal protein L19 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E335 Neighboring gene STARR-positive B cell enhancer ABC_E6120 Neighboring gene STARR-positive B cell enhancer ABC_E6121 Neighboring gene STARR-positive B cell enhancer ABC_E6122 Neighboring gene adaptor-related protein complex 1 associated regulatory protein Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:127540571-127540758 Neighboring gene predicted gene 43653 Neighboring gene predicted gene, 35585

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
TRAF-interacting protein with FHA domain-containing protein A
Names
Traf2 binding protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356430.1NP_001343359.1  TRAF-interacting protein with FHA domain-containing protein A

    Status: VALIDATED

    Source sequence(s)
    AC163391, AK041891, AK149408
    Consensus CDS
    CCDS38628.1
    UniProtKB/Swiss-Prot
    Q3TLY9, Q793I8
    UniProtKB/TrEMBL
    I3PQW8
    Related
    ENSMUSP00000126692.2, ENSMUST00000164447.3
    Conserved Domains (1) summary
    cd00060
    Location:46128
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
  2. NM_145133.4NP_660115.1  TRAF-interacting protein with FHA domain-containing protein A

    See identical proteins and their annotated locations for NP_660115.1

    Status: VALIDATED

    Source sequence(s)
    AB062111, AC163391, BY168652
    Consensus CDS
    CCDS38628.1
    UniProtKB/Swiss-Prot
    Q3TLY9, Q793I8
    UniProtKB/TrEMBL
    I3PQW8
    Related
    ENSMUSP00000054036.8, ENSMUST00000054483.14
    Conserved Domains (1) summary
    cd00060
    Location:46128
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    127582524..127592043
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162993.1XP_036018886.1  TRAF-interacting protein with FHA domain-containing protein A isoform X1

    Conserved Domains (1) summary
    cd00060
    Location:174256
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
  2. XM_006501237.4XP_006501300.1  TRAF-interacting protein with FHA domain-containing protein A isoform X2

    See identical proteins and their annotated locations for XP_006501300.1

    UniProtKB/Swiss-Prot
    Q3TLY9, Q793I8
    UniProtKB/TrEMBL
    I3PQW8
    Conserved Domains (1) summary
    cd00060
    Location:46128
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
  3. XM_006501238.5XP_006501301.1  TRAF-interacting protein with FHA domain-containing protein A isoform X2

    See identical proteins and their annotated locations for XP_006501301.1

    UniProtKB/Swiss-Prot
    Q3TLY9, Q793I8
    UniProtKB/TrEMBL
    I3PQW8
    Conserved Domains (1) summary
    cd00060
    Location:46128
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...