Ado 2-aminoethanethiol (cysteamine) dioxygenase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adoprovided by MGI
Official Full Name: 2-aminoethanethiol (cysteamine) dioxygenaseprovided by MGI
Primary source: MGI:MGI:2685083
See related: Ensembl:ENSMUSG00000057134 AllianceGenome:MGI:2685083
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm237
Summary: Enables cysteamine dioxygenase activity. Located in mitochondrion. Orthologous to human ADO (2-aminoethanethiol dioxygenase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 10; 10 B5.1

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (67380341..67384785, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (67544511..67548955, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Crystal Structure of Cysteamine Dioxygenase Reveals the Origin of the Large Substrate Scope of This Vital Mammalian Enzyme.
Title: The Crystal Structure of Cysteamine Dioxygenase Reveals the Origin of the Large Substrate Scope of This Vital Mammalian Enzyme.
Spectroscopic Investigation of Cysteamine Dioxygenase.
Title: Spectroscopic Investigation of Cysteamine Dioxygenase.
Characterization of the nonheme iron center of cysteamine dioxygenase and its interaction with substrates.
Title: Characterization of the nonheme iron center of cysteamine dioxygenase and its interaction with substrates.
cysteamine (2-aminoethanethiol) dioxygenase (ADO)is encoded by the gene Gm237 and belongs to the DUF1637 protein family.
Title: Discovery and characterization of a second mammalian thiol dioxygenase, cysteamine dioxygenase.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Homology

Homologs of the Ado gene: The Ado gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, zebrafish, fruit fly, mosquito, and frog.
Orthologs from Annotation Pipeline: 396 organisms have orthologs with human gene Ado
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteamine dioxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteamine dioxygenase activity	ISO Inferred from Sequence Orthology more info
enables dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IDA Inferred from Direct Assay more info	PubMed
enables iron ion binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables iron ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: 2-aminoethanethiol dioxygenase

Names: cysteamine dioxygenase

NP_001005419.2

EC 1.13.11.19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.