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Kcnh8 potassium voltage-gated channel, subfamily H (eag-related), member 8 [ Mus musculus (house mouse) ]

Gene ID: 211468, updated on 8-Dec-2022

Summary

Official Symbol
Kcnh8provided by MGI
Official Full Name
potassium voltage-gated channel, subfamily H (eag-related), member 8provided by MGI
Primary source
MGI:MGI:2445160
See related
Ensembl:ENSMUSG00000035580 AllianceGenome:MGI:2445160
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ELK; ELK1; ELK3; Kv12.1; C130090D05Rik
Summary
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and voltage-gated potassium channel activity. Predicted to be involved in negative regulation of apoptotic process; potassium ion transmembrane transport; and regulation of membrane potential. Predicted to act upstream of or within ion transport and regulation of ion transmembrane transport. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human KCNH8 (potassium voltage-gated channel subfamily H member 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in whole brain E14.5 (RPKM 1.5), CNS E14 (RPKM 1.3) and 9 other tissues See more
Orthologs
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Genomic context

See Kcnh8 in Genome Data Viewer
Location:
17; 17 C
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (52909535..53286892)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (52602709..52979194)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 19585 Neighboring gene predicted gene, 41600 Neighboring gene predicted gene 27217 Neighboring gene 3-phosphoglycerate dehydrogenase pseudogene Neighboring gene thioredoxin-like protein 4A pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables voltage-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables voltage-gated potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
potassium voltage-gated channel subfamily H member 8
Names
ELK channel 3
ether-a-go-go-like potassium channel 3
potassium voltage-gated channel, subfamily H, member 8
voltage-gated potassium channel subunit Kv12.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031811.2NP_001026981.2  potassium voltage-gated channel subfamily H member 8

    Status: VALIDATED

    Source sequence(s)
    AC125051, AC131674, AK048629, BC029690, CJ165858
    Consensus CDS
    CCDS57101.1
    UniProtKB/Swiss-Prot
    P59111
    UniProtKB/TrEMBL
    F6TUN6
    Related
    ENSMUSP00000049206.10, ENSMUST00000039366.11
    Conserved Domains (6) summary
    COG0664
    Location:548707
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:551662
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00130
    Location:42133
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00520
    Location:239481
    Ion_trans; Ion transport protein
    pfam07885
    Location:421475
    Ion_trans_2; Ion channel
    pfam13426
    Location:29135
    PAS_9; PAS domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    52909535..53286892
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160442.1XP_036016335.1  potassium voltage-gated channel subfamily H member 8 isoform X1

    Conserved Domains (3) summary
    PLN03192
    Location:175616
    PLN03192; Voltage-dependent potassium channel; Provisional
    COG0664
    Location:549708
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    pfam13426
    Location:40135
    PAS_9; PAS domain
  2. XM_036160443.1XP_036016336.1  potassium voltage-gated channel subfamily H member 8 isoform X2

    Conserved Domains (3) summary
    PLN03192
    Location:97538
    PLN03192; Voltage-dependent potassium channel; Provisional
    COG0664
    Location:471630
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    pfam13426
    Location:1557
    PAS_9; PAS domain