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Pla2g4b phospholipase A2, group IVB (cytosolic) [ Mus musculus (house mouse) ]

Gene ID: 211429, updated on 27-Nov-2024

Summary

Official Symbol
Pla2g4bprovided by MGI
Official Full Name
phospholipase A2, group IVB (cytosolic)provided by MGI
Primary source
MGI:MGI:2384819
See related
Ensembl:ENSMUSG00000098488 AllianceGenome:MGI:2384819
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1013; cPLA2-beta; A030011C02Rik
Summary
Enables lysophospholipase activity and phospholipase A2 activity. Predicted to be involved in glycerophospholipid catabolic process. Predicted to be located in early endosome membrane and mitochondrial inner membrane. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; eye; genitourinary system; nervous system; and respiratory system. Orthologous to several human genes including PLA2G4B (phospholipase A2 group IVB). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in whole brain E14.5 (RPKM 10.6), CNS E14 (RPKM 10.4) and 27 other tissues See more
Orthologs
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Genomic context

See Pla2g4b in Genome Data Viewer
Location:
2 E5; 2 60.09 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (119863914..119873514)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (120033433..120043033)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase binding protein 1 Neighboring gene microRNA 7665 Neighboring gene predicted gene, 28042 Neighboring gene jumonji domain containing 7 Neighboring gene spectrin beta, non-erythrocytic 5 Neighboring gene EH-domain containing 4 Neighboring gene STARR-seq mESC enhancer starr_05504 Neighboring gene STARR-positive B cell enhancer ABC_E226 Neighboring gene phospholipase A2, group IVE Neighboring gene predicted gene, 52575

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1)  1 citation
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough Gm28042

Readthrough gene: Gm28042, Included gene: Jmjd7

Clone Names

  • MGC28892

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium-dependent phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium-dependent phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium-dependent phospholipase A2 activity ISO
Inferred from Sequence Orthology
more info
 
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium-independent phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
 
enables lysophospholipase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables lysophospholipase activity ISO
Inferred from Sequence Orthology
more info
 
enables phospholipase A1 activity ISO
Inferred from Sequence Orthology
more info
 
enables phospholipase A2 activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in glycerophospholipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phospholipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cytosolic phospholipase A2 beta
Names
lysophospholipase A1 group IVB
phospholipase A2 group IVB
NP_663353.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145378.4NP_663353.3  cytosolic phospholipase A2 beta

    See identical proteins and their annotated locations for NP_663353.3

    Status: VALIDATED

    Source sequence(s)
    AK137721, AL833774, DQ888308
    Consensus CDS
    CCDS38209.2
    UniProtKB/Swiss-Prot
    P0C871
    UniProtKB/TrEMBL
    B7ZCM8, Q06G06
    Related
    ENSMUSP00000118458.2, ENSMUST00000126150.2
    Conserved Domains (2) summary
    cd04036
    Location:19137
    C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
    cl11396
    Location:250779
    Patatin_and_cPLA2; Patatins and Phospholipases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    119863914..119873514
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)