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ETFB electron transfer flavoprotein subunit beta [ Homo sapiens (human) ]

Gene ID: 2109, updated on 27-Dec-2018

Summary

Official Symbol
ETFBprovided by HGNC
Official Full Name
electron transfer flavoprotein subunit betaprovided by HGNC
Primary source
HGNC:HGNC:3482
See related
Ensembl:ENSG00000105379 MIM:130410
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MADD; FP585
Summary
This gene encodes electron-transfer-flavoprotein, beta polypeptide, which shuttles electrons between primary flavoprotein dehydrogenases involved in mitochondrial fatty acid and amino acid catabolism and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. The gene deficiencies have been implicated in type II glutaricaciduria. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in liver (RPKM 75.6), fat (RPKM 65.8) and 25 other tissues See more
Orthologs

Genomic context

See ETFB in Genome Data Viewer
Location:
19q13.41
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (51345155..51366418, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51848409..51869672, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene IgLON family member 5 Neighboring gene V-set and immunoglobulin domain containing 10 like Neighboring gene claudin domain containing 2 Neighboring gene natural killer cell granule protein 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify electron-transfer-flavoprotein beta polypeptide (ETFB), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify electron-transfer-flavoprotein beta polypeptide (ETFB), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify electron-transfer-flavoprotein beta polypeptide (ETFB), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify electron-transfer-flavoprotein beta polypeptide (ETFB), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of electron-transfer-flavoprotein, beta polypeptide (ETFB) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
electron transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
electron transfer activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
electron transport chain IEA
Inferred from Electronic Annotation
more info
 
fatty acid beta-oxidation using acyl-CoA dehydrogenase IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
electron transfer flavoprotein subunit beta
Names
beta-ETF
electron transfer flavoprotein beta subunit
electron transfer flavoprotein, beta polypeptide
electron-transferring-flavoprotein, beta polypeptide

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007115.1 RefSeqGene

    Range
    5001..26264
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001014763.1NP_001014763.1  electron transfer flavoprotein subunit beta isoform 2

    See identical proteins and their annotated locations for NP_001014763.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks the 5' exon but has an alternate 5' segment, as compared to variant 1. The encoded isoform (2) has a longer and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AF370381, AK055285, BG281641
    Consensus CDS
    CCDS33085.1
    UniProtKB/Swiss-Prot
    P38117
    Related
    ENSP00000346173.3, ENST00000354232.8
    Conserved Domains (1) summary
    cd01714
    Location:110301
    ETF_beta; The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an ...
  2. NM_001985.2NP_001976.1  electron transfer flavoprotein subunit beta isoform 1

    See identical proteins and their annotated locations for NP_001976.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the shorter isoform (1).
    Source sequence(s)
    BG281641, BG399783, X71129
    Consensus CDS
    CCDS12828.1
    UniProtKB/Swiss-Prot
    P38117
    Related
    ENSP00000311930.3, ENST00000309244.8
    Conserved Domains (1) summary
    cd01714
    Location:5210
    ETF_beta; The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    51345155..51366418 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451418.1XP_024307186.1  electron transfer flavoprotein subunit beta isoform X1

    Conserved Domains (1) summary
    cd01714
    Location:1173
    ETF_beta; The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an ...
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