U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Brcc3 BRCA1/BRCA2-containing complex, subunit 3 [ Mus musculus (house mouse) ]

Gene ID: 210766, updated on 9-Mar-2023

Summary

Go to the top of the page Help
Official Symbol
Brcc3provided by MGI
Official Full Name
BRCA1/BRCA2-containing complex, subunit 3provided by MGI
Primary source
MGI:MGI:2389572
See related
Ensembl:ENSMUSG00000031201 AllianceGenome:MGI:2389572
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C6.1A
Summary
Predicted to enable enzyme regulator activity; peptidase activity; and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in several processes, including histone H2A K63-linked deubiquitination; mitotic G2 DNA damage checkpoint signaling; and positive regulation of DNA repair. Predicted to act upstream of or within response to X-ray. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of BRCA1-A complex; BRISC complex; and nuclear ubiquitin ligase complex. Is expressed in bladder; male associated reproductive structure; testis; ureter; and urethra of male. Orthologous to human BRCC3 (BRCA1/BRCA2-containing complex subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 5.2), liver E14 (RPKM 5.1) and 24 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Brcc3 in Genome Data Viewer
Location:
X; X A7.3
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (74460234..74499307)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (75416628..75455702)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene coagulation factor VIII Neighboring gene FUN14 domain containing 2 Neighboring gene C-x(9)-C motif containing 4 Neighboring gene mature T cell proliferation 1 Neighboring gene zinc finger and SCAN domain containing 12 pseudogene Neighboring gene non-histone chromosomal protein HMG-14 pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Inhibition of CD82 improves colitis by increasing NLRP3 deubiquitination by BRCC3. Kim JS, et al. Cell Mol Immunol, 2023 Feb. PMID 36600050,
  2. Regulation of oxidized LDL-induced inflammatory process through NLRP3 inflammasome activation by the deubiquitinating enzyme BRCC36. Singh M, et al. Inflamm Res, 2019 Dec. PMID 31485755
  3. Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity. Py BF, et al. Mol Cell, 2013 Jan 24. PMID 23246432
  4. Excessive deubiquitination of NLRP3-R779C variant contributes to very-early-onset inflammatory bowel disease development. Zhou L, et al. J Allergy Clin Immunol, 2021 Jan. PMID 32941940
  5. The chromosomal translocation t(X;14)(q28;q11) in T-cell pro-lymphocytic leukaemia breaks within one gene and activates another. Fisch P, et al. Oncogene, 1993 Dec. PMID 8247530

See all (41) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of CD82 improves colitis by increasing NLRP3 deubiquitination by BRCC3.
    Title: Inhibition of CD82 improves colitis by increasing NLRP3 deubiquitination by BRCC3.
  2. Autologous K63 deubiquitylation within the BRCA1-A complex licenses DNA damage recognition.
    Title: Autologous K63 deubiquitylation within the BRCA1-A complex licenses DNA damage recognition.
  3. The BRCC3 regulated by Cdk5 promotes the activation of neuronal NLRP3 inflammasome in Parkinson's disease models.
    Title: The BRCC3 regulated by Cdk5 promotes the activation of neuronal NLRP3 inflammasome in Parkinson's disease models.
  4. We report here for the first time that oxLDL-induced NLRP3 inflammasome stabilization and activation occurs due to modulation by BRCC36 activity in murine macrophages.
    Title: Regulation of oxidized LDL-induced inflammatory process through NLRP3 inflammasome activation by the deubiquitinating enzyme BRCC36.
  5. The deubiquitinating enzyme, BRCC3, is a critical regulator of NLRP3 activity by promoting its deubiquitination.
    Title: Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC29148

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables K63-linked deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables enzyme regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal-dependent deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal-dependent deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables metallopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables metallopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in double-strand break repair ISO
Inferred from Sequence Orthology
more info
  
involved_in histone H2A K63-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in histone H2A K63-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in histone H2A K63-linked deubiquitination NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in histone H2A monoubiquitination NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitotic G2 DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic G2/M transition checkpoint NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of NLRP3 inflammasome complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of NLRP3 inflammasome complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K63-linked deubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein K63-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autoubiquitination NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein deubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA damage checkpoint NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of DNA repair NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within response to X-ray ISO
Inferred from Sequence Orthology
more info
  
involved_in response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of BRCA1-A complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
part_of BRCA1-A complex ISO
Inferred from Sequence Orthology
more info
  
part_of BRCA1-A complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of BRISC complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
part_of BRISC complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
lys-63-specific deubiquitinase BRCC36
Names
6.1A protein
BRCA1-A complex subunit BRCC36
BRCA1/BRCA2-containing complex subunit 36
BRISC complex subunit BRCC36
NP_001159929.1
NP_001159931.1
NP_001345665.1
NP_001345666.1
NP_666068.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166457.1 → NP_001159929.1  lys-63-specific deubiquitinase BRCC36

    See identical proteins and their annotated locations for NP_001159929.1

    Status: VALIDATED

    Source sequence(s)
    AK149844, AL671860, BC048179
    Consensus CDS
    CCDS41031.1
    UniProtKB/Swiss-Prot
    P46737, Q9D025
    UniProtKB/TrEMBL
    A0A8C6IN92
    Related
    ENSMUSP00000033544.8, ENSMUST00000033544.14
    Conserved Domains (1) summary
    cd08068
    Location:13 → 267
    MPN_BRCC36; Mov34/MPN/PAD-1 family: BRCC36, a subunit of BRCA1-A complex

  2. NM_001166459.1 → NP_001159931.1  lys-63-specific deubiquitinase BRCC36

    See identical proteins and their annotated locations for NP_001159931.1

    Status: VALIDATED

    Source sequence(s)
    AK011876, AL671860, CD774860
    Consensus CDS
    CCDS41031.1
    UniProtKB/Swiss-Prot
    P46737, Q9D025
    UniProtKB/TrEMBL
    A0A8C6IN92
    Conserved Domains (1) summary
    cd08068
    Location:13 → 267
    MPN_BRCC36; Mov34/MPN/PAD-1 family: BRCC36, a subunit of BRCA1-A complex

  3. NM_001358736.1 → NP_001345665.1  lys-63-specific deubiquitinase BRCC36

    Status: VALIDATED

    Source sequence(s)
    AL671860, CD774860
    Consensus CDS
    CCDS41031.1
    UniProtKB/Swiss-Prot
    Q9D025
    UniProtKB/TrEMBL
    A0A8C6IN92
    Conserved Domains (1) summary
    cd08068
    Location:13 → 267
    MPN_BRCC36; Mov34/MPN/PAD-1 family: BRCC36, a subunit of BRCA1-A complex

  4. NM_001358737.1 → NP_001345666.1  lys-63-specific deubiquitinase BRCC36

    Status: VALIDATED

    Source sequence(s)
    AL671860, BC048179
    Consensus CDS
    CCDS41031.1
    UniProtKB/Swiss-Prot
    Q9D025
    UniProtKB/TrEMBL
    A0A8C6IN92
    Related
    ENSMUSP00000109708.2, ENSMUST00000114074.8
    Conserved Domains (1) summary
    cd08068
    Location:13 → 267
    MPN_BRCC36; Mov34/MPN/PAD-1 family: BRCC36, a subunit of BRCA1-A complex

  5. NM_145956.4 → NP_666068.1  lys-63-specific deubiquitinase BRCC36

    See identical proteins and their annotated locations for NP_666068.1

    Status: VALIDATED

    Source sequence(s)
    AK030736, AL671860, BC048179
    Consensus CDS
    CCDS41031.1
    UniProtKB/Swiss-Prot
    P46737, Q9D025
    UniProtKB/TrEMBL
    A0A8C6IN92
    Conserved Domains (1) summary
    cd08068
    Location:13 → 267
    MPN_BRCC36; Mov34/MPN/PAD-1 family: BRCC36, a subunit of BRCA1-A complex

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    74460234..74499307
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46737.1 GenPept UniProtKB/Swiss-Prot:P46737

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous