U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Kcnk12 potassium channel, subfamily K, member 12 [ Mus musculus (house mouse) ]

Gene ID: 210741, updated on 5-Mar-2024

Summary

Official Symbol
Kcnk12provided by MGI
Official Full Name
potassium channel, subfamily K, member 12provided by MGI
Primary source
MGI:MGI:2684043
See related
Ensembl:ENSMUSG00000050138 AllianceGenome:MGI:2684043
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mntk1
Summary
Predicted to enable potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport and stabilization of membrane potential. Predicted to be integral component of plasma membrane. Orthologous to human KCNK12 (potassium two pore domain channel subfamily K member 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 13.2), ovary adult (RPKM 10.6) and 6 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Kcnk12 in Genome Data Viewer
Location:
17 E4; 17 57.87 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (88049100..88106329, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (87745821..87797994, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene epithelial cell adhesion molecule Neighboring gene STARR-seq mESC enhancer starr_43514 Neighboring gene STARR-positive B cell enhancer ABC_E7565 Neighboring gene STARR-seq mESC enhancer starr_43516 Neighboring gene mutS homolog 2 Neighboring gene STARR-seq mESC enhancer starr_43518 Neighboring gene STARR-seq mESC enhancer starr_43519 Neighboring gene STARR-seq mESC enhancer starr_43521 Neighboring gene predicted gene, 41649 Neighboring gene STARR-seq mESC enhancer starr_43523 Neighboring gene STARR-seq mESC enhancer starr_43524 Neighboring gene STARR-seq mESC enhancer starr_43525 Neighboring gene STARR-seq mESC enhancer starr_43526 Neighboring gene STARR-seq mESC enhancer starr_43527 Neighboring gene ribosomal protein L36, pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables outward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in stabilization of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
potassium channel subfamily K member 12

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199251.1NP_954859.1  potassium channel subfamily K member 12

    See identical proteins and their annotated locations for NP_954859.1

    Status: VALIDATED

    Source sequence(s)
    AB052939
    Consensus CDS
    CCDS29020.1
    UniProtKB/TrEMBL
    Q76M80
    Related
    ENSMUSP00000053595.8, ENSMUST00000055221.9
    Conserved Domains (1) summary
    pfam07885
    Location:222304
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    88049100..88106329 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160433.1XP_036016326.1  potassium channel subfamily K member 12 isoform X1

    Conserved Domains (1) summary
    pfam07885
    Location:116198
    Ion_trans_2; Ion channel
  2. XM_036160434.1XP_036016327.1  potassium channel subfamily K member 12 isoform X2

    Conserved Domains (1) summary
    pfam07885
    Location:89171
    Ion_trans_2; Ion channel