Mettl14 methyltransferase like 14 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mettl14provided by MGI
Official Full Name: methyltransferase like 14provided by MGI
Primary source: MGI:MGI:2442926
See related: Ensembl:ENSMUSG00000028114 AllianceGenome:MGI:2442926
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA1627; G430022H21Rik
Summary: Enables mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity. Involved in several processes, including forebrain radial glial cell differentiation; mRNA destabilization; and mRNA metabolic process. Located in nucleus. Part of RNA N6-methyladenosine methyltransferase complex. Orthologous to human METTL14 (methyltransferase 14, N6-adenosine-methyltransferase subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 10.1), CNS E14 (RPKM 6.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3; 3 G1

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (123161944..123179639, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (123368295..123385990, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

METTL14 alleviates the development of osteoporosis in ovariectomized mice by upregulating m[6]A level of SIRT1 mRNA.
Title: METTL14 alleviates the development of osteoporosis in ovariectomized mice by upregulating m(6)A level of SIRT1 mRNA.
METTL14 upregulates TCF1 through m6A mRNA methylation to stimulate osteogenic activity in osteoporosis.
Title: METTL14 upregulates TCF1 through m6A mRNA methylation to stimulate osteogenic activity in osteoporosis.
METTL14 Regulates Intestine Cellular Senescence through m[6]A Modification of Lamin B Receptor.
Title: METTL14 Regulates Intestine Cellular Senescence through m(6)A Modification of Lamin B Receptor.
Mettl14 mutation restrains liver regeneration by attenuating mitogens derived from non-parenchymal liver cells.
Title: Mettl14 mutation restrains liver regeneration by attenuating mitogens derived from non-parenchymal liver cells.
Mettl14-mediated m6A modification enhances the function of Foxp3<sup>+</sup> regulatory T cells and promotes allograft acceptance.
Title: Mettl14-mediated m6A modification enhances the function of Foxp3(+) regulatory T cells and promotes allograft acceptance.
Downregulation of METTL14 improves postmenopausal osteoporosis via IGF2BP1 dependent posttranscriptional silencing of SMAD1.
Title: Downregulation of METTL14 improves postmenopausal osteoporosis via IGF2BP1 dependent posttranscriptional silencing of SMAD1.
METTL14 Regulates Osteogenesis of Bone Marrow Mesenchymal Stem Cells via Inducing Autophagy Through m6A/IGF2BPs/Beclin-1 Signal Axis.
Title: METTL14 Regulates Osteogenesis of Bone Marrow Mesenchymal Stem Cells via Inducing Autophagy Through m6A/IGF2BPs/Beclin-1 Signal Axis.
METTL14-dependent m(6)A modification controls iNKT cell development and function.
Title: METTL14-dependent m(6)A modification controls iNKT cell development and function.
Mettl14-mediated m6A modification is essential for visual function and retinal photoreceptor survival.
Title: Mettl14-mediated m6A modification is essential for visual function and retinal photoreceptor survival.
[Lipopolysaccharide induces inflammation and up-regulates the expression of methyltransferase-like 3 (METTL3) and METTL14 in human and mouse intestinal epithelial cells].
Title: [Lipopolysaccharide induces inflammation and up-regulates the expression of methyltransferase-like 3 (METTL3) and METTL14 in human and mouse intestinal epithelial cells].

Submit: New GeneRIF Correction See all GeneRIFs (38)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (10) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

18.MMHAP27FLF3.seq (e-PCR)
- UniSTS:123377

Homology

Homologs of the Mettl14 gene: The Mettl14 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, E.gossypii, and frog.
Orthologs from Annotation Pipeline: 491 organisms have orthologs with human gene Mettl14
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA (N6-adenosine)-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA methylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in forebrain radial glial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gliogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA destabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA methylation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in mRNA methylation	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA methylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA methylation	ISO Inferred from Sequence Orthology more info
involved_in mRNA methylation	NAS Non-traceable Author Statement more info	PubMed
involved_in mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hematopoietic progenitor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of RNA N6-methyladenosine methyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of RNA N6-methyladenosine methyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of RNA N6-methyladenosine methyltransferase complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: N6-adenosine-methyltransferase non-catalytic subunit

Names: N6-adenosine-methyltransferase subunit METTL14; methyltransferase-like protein 14; snoRNA MBII-84

NP_964000.2

EC 2.1.1.62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.