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ESRRB estrogen related receptor beta [ Homo sapiens (human) ]

Gene ID: 2103, updated on 8-Dec-2022

Summary

Official Symbol
ESRRBprovided by HGNC
Official Full Name
estrogen related receptor betaprovided by HGNC
Primary source
HGNC:HGNC:3473
See related
Ensembl:ENSG00000119715 MIM:602167; AllianceGenome:HGNC:3473
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERR2; ERRb; ESRL2; NR3B2; DFNB35; ERRbeta2; ERR beta-2
Summary
This gene encodes a protein with similarity to the estrogen receptor. Its function is unknown; however, a similar protein in mouse plays an essential role in placental development. [provided by RefSeq, Jul 2008]
Expression
Biased expression in kidney (RPKM 4.2), heart (RPKM 1.8) and 2 other tissues See more
Orthologs
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Genomic context

See ESRRB in Genome Data Viewer
Location:
14q24.3
Exon count:
14
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (76310777..76501837)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (70580669..70711193)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (76837614..76968180)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene G-patch domain containing 2 like Neighboring gene uncharacterized LOC105370575 Neighboring gene Sharpr-MPRA regulatory region 6100 Neighboring gene uncharacterized LOC105370576 Neighboring gene CYCS pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Does parental expressed emotion moderate genetic effects in ADHD? An exploration using a genome wide association scan.
EBI GWAS Catalog
Genome-wide association study identifies three novel genetic markers associated with elite endurance performance.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
 
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables RNA polymerase II complex binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables cis-regulatory region sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables nuclear steroid receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding EXP
Inferred from Experiment
more info
PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables steroid binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell dedifferentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT involved_in embryonic placenta development NAS
Non-traceable Author Statement
more info
PubMed 
involved_in inner ear development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in intracellular receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of stem cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in photoreceptor cell maintenance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of stem cell population maintenance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transcription involved in G1/S transition of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transcription involved in G2/M transition of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of stem cell division ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in stem cell division ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in stem cell population maintenance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in steroid hormone mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in condensed chromosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
steroid hormone receptor ERR2
Names
estrogen receptor-like 2
estrogen-related nuclear receptor beta
nuclear receptor ERRB2
nuclear receptor subfamily 3 group B member 2
orphan nuclear receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012278.3 RefSeqGene

    Range
    70362..196062
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001379180.1NP_001366109.1  steroid hormone receptor ERR2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC008050, AC016543
    Consensus CDS
    CCDS91910.1
    UniProtKB/TrEMBL
    A0A2R8Y491
    Related
    ENSP00000493776.1, ENST00000644823.1
    Conserved Domains (2) summary
    cd06946
    Location:233452
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:119214
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  2. NM_001411038.1NP_001397967.1  steroid hormone receptor ERR2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC008050, AC016543
    Consensus CDS
    CCDS91909.1
    UniProtKB/TrEMBL
    E7EWD9
  3. NM_004452.4NP_004443.3  steroid hormone receptor ERR2 isoform 1

    See identical proteins and their annotated locations for NP_004443.3

    Status: REVIEWED

    Source sequence(s)
    AC008050, AC016543
    Consensus CDS
    CCDS9850.2
    UniProtKB/Swiss-Prot
    O95718
    Related
    ENSP00000370270.2, ENST00000380887.7
    Conserved Domains (2) summary
    cd06946
    Location:212431
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:98193
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    76310777..76501837
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047431079.1XP_047287035.1  steroid hormone receptor ERR2 isoform X2

  2. XM_047431080.1XP_047287036.1  steroid hormone receptor ERR2 isoform X6

    Related
    ENSP00000424992.2, ENST00000512784.6
  3. XM_011536553.3XP_011534855.1  steroid hormone receptor ERR2 isoform X3

    Conserved Domains (2) summary
    cd06946
    Location:233452
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:119214
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  4. XM_011536547.3XP_011534849.1  steroid hormone receptor ERR2 isoform X1

    Conserved Domains (3) summary
    cd06946
    Location:233452
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:119214
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    pfam15502
    Location:455524
    MPLKIP; M-phase-specific PLK1-interacting protein
  5. XM_011536554.3XP_011534856.1  steroid hormone receptor ERR2 isoform X4

    Conserved Domains (3) summary
    cd06946
    Location:233452
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:119214
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    pfam15502
    Location:455522
    MPLKIP; M-phase-specific PLK1-interacting protein
  6. XM_024449508.2XP_024305276.1  steroid hormone receptor ERR2 isoform X5

    Related
    ENSP00000423004.1, ENST00000505752.6
    Conserved Domains (2) summary
    cd06946
    Location:233452
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:119214
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  7. XM_011536550.3XP_011534852.1  steroid hormone receptor ERR2 isoform X2

    See identical proteins and their annotated locations for XP_011534852.1

    Conserved Domains (3) summary
    cd06946
    Location:212431
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:98193
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    pfam15502
    Location:434503
    MPLKIP; M-phase-specific PLK1-interacting protein

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    70580669..70711193
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)