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Lpp LIM domain containing preferred translocation partner in lipoma [ Mus musculus (house mouse) ]

Gene ID: 210126, updated on 14-May-2024

Summary

Official Symbol
Lppprovided by MGI
Official Full Name
LIM domain containing preferred translocation partner in lipomaprovided by MGI
Primary source
MGI:MGI:2441849
See related
Ensembl:ENSMUSG00000033306 AllianceGenome:MGI:2441849
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D630048H16; 9430020K16Rik; B130055L10Rik
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in cell-cell adhesion. Predicted to act upstream of or within cell adhesion. Predicted to be located in cytosol. Predicted to be active in focal adhesion and stress fiber. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and musculoskeletal system. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human LPP (LIM domain containing preferred translocation partner in lipoma). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 60.6), subcutaneous fat pad adult (RPKM 8.5) and 10 other tissues See more
Orthologs
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Genomic context

See Lpp in Genome Data Viewer
Location:
16 B1; 16 16.17 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (24212100..24811328)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (24393350..24992578)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40457 Neighboring gene predicted gene, 41434 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:24428914-24429115 Neighboring gene BMP2 inducible kinase pseudogene Neighboring gene predicted gene, 24440 Neighboring gene LIM domain containing preferred translocation partner in lipoma, opposite strand Neighboring gene STARR-positive B cell enhancer ABC_E7434 Neighboring gene STARR-seq mESC enhancer starr_40461 Neighboring gene STARR-seq mESC enhancer starr_40463 Neighboring gene mortality factor 4 like 1, pseudogene 1 Neighboring gene STARR-positive B cell enhancer ABC_E2458 Neighboring gene STARR-seq mESC enhancer starr_40465 Neighboring gene microRNA 28a Neighboring gene predicted gene, 22672 Neighboring gene predicted gene, 52245 Neighboring gene STARR-seq mESC enhancer starr_40468 Neighboring gene STARR-seq mESC enhancer starr_40471 Neighboring gene RIKEN cDNA A230028O05 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:25055618-25055819 Neighboring gene STARR-seq mESC enhancer starr_40472 Neighboring gene predicted gene, 52256

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
is_active_in stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
lipoma-preferred partner homolog
Names
lipoma preferred partner

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145952.1NP_001139424.1  lipoma-preferred partner homolog isoform 1

    See identical proteins and their annotated locations for NP_001139424.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC135567, AK040643, AK050035, AK054550, AK085890, BF018106
    Consensus CDS
    CCDS28083.1
    UniProtKB/Swiss-Prot
    Q5U407, Q8BFW7, Q8BHI1, Q8BKI0, Q8BKN2, Q8BLF4, Q8BLG3, Q8C101
    Related
    ENSMUSP00000078005.3, ENSMUST00000078988.10
    Conserved Domains (4) summary
    cd09350
    Location:417470
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    PRK14086
    Location:192388
    dnaA; chromosomal replication initiator protein DnaA
    PRK14971
    Location:139240
    PRK14971; DNA polymerase III subunit gamma/tau
    cl02475
    Location:537602
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  2. NM_001145954.1NP_001139426.1  lipoma-preferred partner homolog isoform 2

    See identical proteins and their annotated locations for NP_001139426.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This results in a shorter isoform (2) with a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC135567, AK029567, AK040643, AK050035, AK085890, BF018106
    Consensus CDS
    CCDS49807.1
    UniProtKB/Swiss-Prot
    Q8BFW7
    Related
    ENSMUSP00000110969.3, ENSMUST00000115314.4
    Conserved Domains (3) summary
    cd09350
    Location:292345
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cl02475
    Location:412477
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    cl08186
    Location:42160
    DUF3251; Protein of unknown function (DUF3251)
  3. NM_178665.5NP_848780.3  lipoma-preferred partner homolog isoform 1

    See identical proteins and their annotated locations for NP_848780.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC135567, AK040643, AK050035, AK085890, BF018106, CJ166632
    Consensus CDS
    CCDS28083.1
    UniProtKB/Swiss-Prot
    Q5U407, Q8BFW7, Q8BHI1, Q8BKI0, Q8BKN2, Q8BLF4, Q8BLG3, Q8C101
    Related
    ENSMUSP00000036304.7, ENSMUST00000038053.14
    Conserved Domains (4) summary
    cd09350
    Location:417470
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    PRK14086
    Location:192388
    dnaA; chromosomal replication initiator protein DnaA
    PRK14971
    Location:139240
    PRK14971; DNA polymerase III subunit gamma/tau
    cl02475
    Location:537602
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    24212100..24811328
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316922.3XP_017172411.1  lipoma-preferred partner homolog isoform X2

    Conserved Domains (4) summary
    cd09350
    Location:416469
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    PRK14086
    Location:191387
    dnaA; chromosomal replication initiator protein DnaA
    PRK14971
    Location:138239
    PRK14971; DNA polymerase III subunit gamma/tau
    cl02475
    Location:536601
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  2. XM_030249029.1XP_030104889.1  lipoma-preferred partner homolog isoform X1

    UniProtKB/Swiss-Prot
    Q5U407, Q8BFW7, Q8BHI1, Q8BKI0, Q8BKN2, Q8BLF4, Q8BLG3, Q8C101
    Conserved Domains (4) summary
    cd09350
    Location:417470
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    PRK14086
    Location:192388
    dnaA; chromosomal replication initiator protein DnaA
    PRK14971
    Location:139240
    PRK14971; DNA polymerase III subunit gamma/tau
    cl02475
    Location:537602
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  3. XM_030249032.1XP_030104892.1  lipoma-preferred partner homolog isoform X2

    Conserved Domains (4) summary
    cd09350
    Location:416469
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    PRK14086
    Location:191387
    dnaA; chromosomal replication initiator protein DnaA
    PRK14971
    Location:138239
    PRK14971; DNA polymerase III subunit gamma/tau
    cl02475
    Location:536601
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  4. XM_006521957.5XP_006522020.1  lipoma-preferred partner homolog isoform X1

    See identical proteins and their annotated locations for XP_006522020.1

    UniProtKB/Swiss-Prot
    Q5U407, Q8BFW7, Q8BHI1, Q8BKI0, Q8BKN2, Q8BLF4, Q8BLG3, Q8C101
    Conserved Domains (4) summary
    cd09350
    Location:417470
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    PRK14086
    Location:192388
    dnaA; chromosomal replication initiator protein DnaA
    PRK14971
    Location:139240
    PRK14971; DNA polymerase III subunit gamma/tau
    cl02475
    Location:537602
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  5. XM_030249028.2XP_030104888.1  lipoma-preferred partner homolog isoform X1

    UniProtKB/Swiss-Prot
    Q5U407, Q8BFW7, Q8BHI1, Q8BKI0, Q8BKN2, Q8BLF4, Q8BLG3, Q8C101
    Conserved Domains (4) summary
    cd09350
    Location:417470
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    PRK14086
    Location:192388
    dnaA; chromosomal replication initiator protein DnaA
    PRK14971
    Location:139240
    PRK14971; DNA polymerase III subunit gamma/tau
    cl02475
    Location:537602
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  6. XM_030249031.1XP_030104891.1  lipoma-preferred partner homolog isoform X1

    UniProtKB/Swiss-Prot
    Q5U407, Q8BFW7, Q8BHI1, Q8BKI0, Q8BKN2, Q8BLF4, Q8BLG3, Q8C101
    Conserved Domains (4) summary
    cd09350
    Location:417470
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    PRK14086
    Location:192388
    dnaA; chromosomal replication initiator protein DnaA
    PRK14971
    Location:139240
    PRK14971; DNA polymerase III subunit gamma/tau
    cl02475
    Location:537602
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  7. XM_030249030.2XP_030104890.1  lipoma-preferred partner homolog isoform X1

    UniProtKB/Swiss-Prot
    Q5U407, Q8BFW7, Q8BHI1, Q8BKI0, Q8BKN2, Q8BLF4, Q8BLG3, Q8C101
    Conserved Domains (4) summary
    cd09350
    Location:417470
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    PRK14086
    Location:192388
    dnaA; chromosomal replication initiator protein DnaA
    PRK14971
    Location:139240
    PRK14971; DNA polymerase III subunit gamma/tau
    cl02475
    Location:537602
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers