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ESR2 estrogen receptor 2 [ Homo sapiens (human) ]

Gene ID: 2100, updated on 11-Nov-2018

Summary

Official Symbol
ESR2provided by HGNC
Official Full Name
estrogen receptor 2provided by HGNC
Primary source
HGNC:HGNC:3468
See related
Ensembl:ENSG00000140009 MIM:601663; Vega:OTTHUMG00000141306
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Erb; ESRB; ESTRB; NR3A2; ER-BETA; ESR-BETA
Summary
This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 1.8), adrenal (RPKM 1.1) and 16 other tissues See more
Orthologs

Genomic context

See ESR2 in Genome Data Viewer
Location:
14q23.2-q23.3
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (64226712..64338631, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (64693751..64805268, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene spectrin repeat containing nuclear envelope protein 2 Neighboring gene ribosomal protein S28 pseudogene 1 Neighboring gene microRNA 548h-1 Neighboring gene testis expressed 21, pseudogene Neighboring gene methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 Neighboring gene zinc finger and BTB domain containing 25

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env 17beta-estradiol (17beta-E2) protects human neuroblastoma cells from cell death elicited by HIV-1 gp120; estrogen receptor antagonists antagonize 17beta-E2-mediated inhibition gp120-induced cell death PubMed
Tat tat HIV-1 Tat-induced apoptosis through increased expression of anti-apoptotic protein Bcl-2, proapoptotic protein Bax and activation of caspases CASP3 and CASP9 is inhibited by estrogen receptor beta (ER beta)-mediated estrogen treatment PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Breast cancer, organism-specific biosystem (from KEGG)
    Breast cancer, organism-specific biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
  • Breast cancer, conserved biosystem (from KEGG)
    Breast cancer, conserved biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
  • Endocrine resistance, organism-specific biosystem (from KEGG)
    Endocrine resistance, organism-specific biosystemEndocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. The most commonly used endocrine therapy agents are selective estrogen receptor modulators (SER...
  • Endocrine resistance, conserved biosystem (from KEGG)
    Endocrine resistance, conserved biosystemEndocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. The most commonly used endocrine therapy agents are selective estrogen receptor modulators (SER...
  • Estrogen signaling pathway, organism-specific biosystem (from KEGG)
    Estrogen signaling pathway, organism-specific biosystemEstrogens are steroid hormones that regulate a plethora of physiological processes in mammals, including reproduction, cardiovascular protection, bone integrity, cellular homeostasis, and behavior. E...
  • Estrogen signaling pathway, conserved biosystem (from KEGG)
    Estrogen signaling pathway, conserved biosystemEstrogens are steroid hormones that regulate a plethora of physiological processes in mammals, including reproduction, cardiovascular protection, bone integrity, cellular homeostasis, and behavior. E...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
    Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
  • Nuclear Receptor transcription pathway, organism-specific biosystem (from REACTOME)
    Nuclear Receptor transcription pathway, organism-specific biosystemA classic example of bifunctional transcription factors is the family of Nuclear Receptor (NR) proteins. These are DNA-binding transcription factors that bind certain hormones, vitamins, and other s...
  • Nuclear Receptors, organism-specific biosystem (from WikiPathways)
    Nuclear Receptors, organism-specific biosystemNuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. In response, th...
  • Ovarian Infertility Genes, organism-specific biosystem (from WikiPathways)
    Ovarian Infertility Genes, organism-specific biosystemOvarian bottleneck genes associated with infertility. A valuable approach to the study of infertility is the comparison of mutations of individual human and mouse genes associated with infertility ph...
  • Plasma membrane estrogen receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
    Plasma membrane estrogen receptor signaling, organism-specific biosystem
    Plasma membrane estrogen receptor signaling
  • Prolactin signaling pathway, organism-specific biosystem (from KEGG)
    Prolactin signaling pathway, organism-specific biosystemProlactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological functions including osmoregulation, lactation, reproduction, growth and development, endocrinology and meta...
  • Prolactin signaling pathway, conserved biosystem (from KEGG)
    Prolactin signaling pathway, conserved biosystemProlactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological functions including osmoregulation, lactation, reproduction, growth and development, endocrinology and meta...
  • Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
    Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding TAS
Traceable Author Statement
more info
PubMed 
DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific NAS
Non-traceable Author Statement
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
estrogen receptor activity TAS
Traceable Author Statement
more info
PubMed 
estrogen response element binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
nuclear receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor antagonist activity NAS
Non-traceable Author Statement
more info
PubMed 
steroid binding ISS
Inferred from Sequence or Structural Similarity
more info
 
steroid binding TAS
Traceable Author Statement
more info
PubMed 
steroid hormone receptor activity TAS
Traceable Author Statement
more info
PubMed 
transcription coactivator activity TAS
Traceable Author Statement
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
estrogen receptor beta
Names
estrogen receptor beta 4
estrogen receptor beta splice variant, ERbeta2delta7
estrogen receptor beta splice variant, ERbeta4delta7
estrogen receptor beta splice variant, ERbeta6
estrogen receptor beta splice variant, ERbeta6delta7
estrogen receptor beta splice variant, ERbeta7
estrogen receptor beta splice variant, ERbeta7delta7
estrogen receptor beta splice variant, ERbetaEx. 4L
estrogen receptor beta splice variant, ERbetaEx. 6L
nuclear receptor subfamily 3 group A member 2
oestrogen receptor beta

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011535.1 RefSeqGene

    Range
    49141..116518
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001040275.1NP_001035365.1  estrogen receptor beta isoform 2

    See identical proteins and their annotated locations for NP_001035365.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (b, also known as 2) differs in the 3' UTR and 3' coding sequence, compared to variant a. The resulting isoform (2) has a distinct and shorter C-terminus, compared to isoform 1, and dominantly inhibits the activity of other estrogen receptor family members. Variants b, k and m encode the same isoform 2.
    Source sequence(s)
    AF051428, AF060555, AL355094, BC024181
    Consensus CDS
    CCDS32096.1
    UniProtKB/Swiss-Prot
    Q92731
    UniProtKB/TrEMBL
    F1D8N3
    Related
    ENSP00000335551.4, ENST00000353772.7
    Conserved Domains (3) summary
    cd06949
    Location:263489
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:144225
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam12497
    Location:16122
    ERbeta_N; Estrogen receptor beta
  2. NM_001214902.1NP_001201831.1  estrogen receptor beta isoform 3

    See identical proteins and their annotated locations for NP_001201831.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (d) differs in the 3' UTR and 3' coding sequence, compared to variant a. The resulting isoform (3, also known as ER-beta4) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AB006590, AL355094, BC024181, DQ838582
    Consensus CDS
    CCDS55920.1
    UniProtKB/Swiss-Prot
    Q92731
    Related
    ENSP00000450488.1, OTTHUMP00000245362, ENST00000555278.5, OTTHUMT00000412157
    Conserved Domains (3) summary
    cd06949
    Location:263468
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:144225
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam12497
    Location:16122
    ERbeta_N; Estrogen receptor beta
  3. NM_001271876.1NP_001258805.1  estrogen receptor beta isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (f) differs in the 3' UTR and 3' coding sequence, compared to variant a. The resulting isoform (5, also known as ER-beta4) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AB006590, AL355094, DQ777076
    Consensus CDS
    CCDS61470.1
    UniProtKB/Swiss-Prot
    Q92731
    UniProtKB/TrEMBL
    Q0PTK2
    Related
    ENSP00000452426.1, OTTHUMP00000245364, ENST00000553796.5, OTTHUMT00000412159
    Conserved Domains (3) summary
    cd06949
    Location:263470
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:144225
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam12497
    Location:16122
    ERbeta_N; Estrogen receptor beta
  4. NM_001271877.1NP_001258806.1  estrogen receptor beta isoform 6

    See identical proteins and their annotated locations for NP_001258806.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (g) lacks two consecutive exons in the coding region compared to variant a. The resulting isoform (6, also known as 5/6) lacks an internal segment compared to isoform 1.
    Source sequence(s)
    AB006590, AF074599, AL161756
    Consensus CDS
    CCDS61469.1
    UniProtKB/Swiss-Prot
    Q92731
    Related
    ENSP00000267525.6, ENST00000267525.10
    Conserved Domains (3) summary
    cd07171
    Location:144225
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam12497
    Location:16122
    ERbeta_N; Estrogen receptor beta
    cl11397
    Location:263407
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  5. NM_001291712.1NP_001278641.1  estrogen receptor beta isoform 2

    See identical proteins and their annotated locations for NP_001278641.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (k) represents an alternative promoter usage and differs in the 5' UTR, 3' coding region and 3' UTR, compared to variant a. The resulting isoform (2) has a distinct and shorter C-terminus, compared to isoform 1. Variants b, k and m encode the same isoform 2.
    Source sequence(s)
    AB006589, AK292370, BC024181, CN366005, KC777386
    Consensus CDS
    CCDS32096.1
    UniProtKB/Swiss-Prot
    Q92731
    UniProtKB/TrEMBL
    F1D8N3
    Related
    ENSP00000450699.1, OTTHUMP00000245360, ENST00000554572.5, OTTHUMT00000412155
    Conserved Domains (3) summary
    cd06949
    Location:263489
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:144225
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam12497
    Location:16122
    ERbeta_N; Estrogen receptor beta
  6. NM_001291723.1NP_001278652.1  estrogen receptor beta isoform 2

    See identical proteins and their annotated locations for NP_001278652.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (l) represents an alternative promoter usage and differs in the 5' UTR, 3' coding region and 3' UTR, compared to variant a. The resulting isoform (2) has a distinct and shorter C-terminus, compared to isoform 1. Variants b, k and m encode the same isoform 2.
    Source sequence(s)
    AK292370, BC024181, BX094834, CN366005
    Consensus CDS
    CCDS32096.1
    UniProtKB/Swiss-Prot
    Q92731
    UniProtKB/TrEMBL
    F1D8N3
    Related
    ENSP00000351412.5, OTTHUMP00000245361, ENST00000358599.9, OTTHUMT00000412156
    Conserved Domains (3) summary
    cd06949
    Location:263489
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:144225
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam12497
    Location:16122
    ERbeta_N; Estrogen receptor beta
  7. NM_001437.2NP_001428.1  estrogen receptor beta isoform 1

    See identical proteins and their annotated locations for NP_001428.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (a, also known as 1) encodes the longest isoform (1).
    Source sequence(s)
    AF051427, AF060555, AL161756
    Consensus CDS
    CCDS9762.1
    UniProtKB/Swiss-Prot
    Q92731
    UniProtKB/TrEMBL
    Q7LCB3
    Related
    ENSP00000343925.4, OTTHUMP00000180647, ENST00000341099.5, OTTHUMT00000280621
    Conserved Domains (3) summary
    cd06949
    Location:263498
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:144225
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam12497
    Location:16122
    ERbeta_N; Estrogen receptor beta

RNA

  1. NR_073496.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (h) uses an alternate 5' and 3' exon structure and lacks an internal exon, compared to variant a. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant a, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB006589, BC024181, CN366005
  2. NR_073497.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (i) lacks an internal exon in the 5' region compared to variant a. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant a, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB006590, AL161756, AY438022
    Related
    ENST00000555483.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    64226712..64338631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021084.1XP_016876573.1  estrogen receptor beta isoform X2

    UniProtKB/Swiss-Prot
    Q92731
    UniProtKB/TrEMBL
    F1D8N3
    Conserved Domains (3) summary
    cd06949
    Location:263489
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:144225
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam12497
    Location:16122
    ERbeta_N; Estrogen receptor beta
  2. XM_017021081.1XP_016876570.1  estrogen receptor beta isoform X1

    UniProtKB/Swiss-Prot
    Q92731
    UniProtKB/TrEMBL
    Q7LCB3
    Conserved Domains (3) summary
    cd06949
    Location:263498
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:144225
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam12497
    Location:16122
    ERbeta_N; Estrogen receptor beta
  3. XM_017021079.1XP_016876568.1  estrogen receptor beta isoform X1

    UniProtKB/Swiss-Prot
    Q92731
    UniProtKB/TrEMBL
    Q7LCB3
    Conserved Domains (3) summary
    cd06949
    Location:263498
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:144225
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam12497
    Location:16122
    ERbeta_N; Estrogen receptor beta
  4. XM_017021080.1XP_016876569.1  estrogen receptor beta isoform X1

    UniProtKB/Swiss-Prot
    Q92731
    UniProtKB/TrEMBL
    Q7LCB3
    Conserved Domains (3) summary
    cd06949
    Location:263498
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:144225
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam12497
    Location:16122
    ERbeta_N; Estrogen receptor beta
  5. XM_017021083.1XP_016876572.1  estrogen receptor beta isoform X1

    UniProtKB/Swiss-Prot
    Q92731
    UniProtKB/TrEMBL
    Q7LCB3
    Related
    ENSP00000451582.1, OTTHUMP00000245365, ENST00000557772.5, OTTHUMT00000412160
    Conserved Domains (3) summary
    cd06949
    Location:263498
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:144225
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam12497
    Location:16122
    ERbeta_N; Estrogen receptor beta
  6. XM_017021082.1XP_016876571.1  estrogen receptor beta isoform X1

    UniProtKB/Swiss-Prot
    Q92731
    UniProtKB/TrEMBL
    Q7LCB3
    Conserved Domains (3) summary
    cd06949
    Location:263498
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:144225
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam12497
    Location:16122
    ERbeta_N; Estrogen receptor beta

RNA

  1. XR_001750187.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001040276.1: Suppressed sequence

    Description
    NM_001040276.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_001214903.1: Suppressed sequence

    Description
    NM_001214903.1: This RefSeq was permanently suppressed because it represents a partial transcript sequence. The complete transcript is a nonsense-mediated mRNA decay (NMD) candidate.
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