Slc38a5 solute carrier family 38, member 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc38a5provided by MGI
Official Full Name: solute carrier family 38, member 5provided by MGI
Primary source: MGI:MGI:2148066
See related: Ensembl:ENSMUSG00000031170
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SN2; JM24; C81234; E330031E14
Expression: Biased expression in genital fat pad adult (RPKM 1166.3) and ovary adult (RPKM 77.4) See more
Orthologs: human all

Genomic context

Location:: X; X A1.1

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
106	current	GRCm38.p4 (GCF_000001635.24)	X	NC_000086.7 (8271381..8280179)
Build 37.2	previous assembly	MGSCv37 (GCF_000001635.18)	X	NC_000086.6 (7848518..7857305)

Chromosome X - NC_000086.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

These results show that Slc38a5 is a key component of the feedback circuit between glucagon receptor signaling in the liver and amino-acid-dependent regulation of pancreatic alpha cell mass in mice.
Title: Amino Acid Transporter Slc38a5 Controls Glucagon Receptor Inhibition-Induced Pancreatic α Cell Hyperplasia in Mice.
ISH and IF revealed SN1 and SN2 expression in the ganglion, inner nuclear, and photoreceptor cell layers.
Title: Expression and function of system N glutamine transporters (SN1/SN2 or SNAT3/SNAT5) in retinal ganglion cells.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1)

Pathways from BioSystems

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Amino acid transport across the plasma membrane, organism-specific biosystem (from REACTOME)
Amino acid transport across the plasma membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GABAergic synapse, organism-specific biosystem (from KEGG)
GABAergic synapse, organism-specific biosystemGamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes o...
GABAergic synapse, conserved biosystem (from KEGG)
GABAergic synapse, conserved biosystemGamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes o...
SLC-mediated transmembrane transport, organism-specific biosystem (from REACTOME)
SLC-mediated transmembrane transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
Transmembrane transport of small molecules, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Transport of inorganic cations/anions and amino acids/oligopeptides, organism-specific biosystem (from REACTOME)
Transport of inorganic cations/anions and amino acids/oligopeptides, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

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Markers

Slc38a5 (e-PCR), detects polymorphism
- UniSTS:547341

NoName (e-PCR)
- UniSTS:487467

RH127037 (e-PCR)
- UniSTS:209500

C81234 (e-PCR)
- UniSTS:160869

Slc38a5 (e-PCR), detects polymorphism
- UniSTS:508543

Slc38a5 (e-PCR), detects polymorphism
- UniSTS:525513

Homology

Homologs of the Slc38a5 gene: The Slc38a5 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, and rat.
Orthologs from Annotation Pipeline: 141 organisms have orthologs with human gene Slc38a5
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
glycine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
glycine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
neutral amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
amino acid transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed
glycine transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed
glycine transport	ISO Inferred from Sequence Orthology more info
neutral amino acid transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
integral component of membrane	IEA Inferred from Electronic Annotation more info
integral component of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sodium-coupled neutral amino acid transporter 5

Names: system N transporter 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172479.3 → NP_766067.2 sodium-coupled neutral amino acid transporter 5

See identical proteins and their annotated locations for NP_766067.2

Status: VALIDATED

Source sequence(s)

AK054485, AK158125, AL805902, BX523289

Consensus CDS

CCDS52990.1

UniProtKB/Swiss-Prot

Q3U1J0

Related

ENSMUSP00000033512.4, ENSMUST00000033512.10

Conserved Domains (2) summary

COG0814
Location:56 → 469

SdaC; Amino acid permease [Amino acid transport and metabolism]

cl00456
Location:56 → 466

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain