Slc38a5 solute carrier family 38, member 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc38a5provided by MGI
Official Full Name: solute carrier family 38, member 5provided by MGI
Primary source: MGI:MGI:2148066
See related: Ensembl:ENSMUSG00000031170 AllianceGenome:MGI:2148066
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SN2; JM24; E330031E14
Summary: Enables L-glutamine, sodium:proton antiporter activity. Involved in L-glutamine import across plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; foregut-midgut junction; liver lobe; metanephros; and pericardium. Orthologous to human SLC38A5 (solute carrier family 38 member 5). [provided by Alliance of Genome Resources, Jun 2025]
Expression: Biased expression in genital fat pad adult (RPKM 1166.3) and ovary adult (RPKM 77.4) See more
Orthologs: human all
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Genomic context

Location:: X A1.1; X 3.74 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (8137620..8146418)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (8271381..8280179)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Impairment of serine transport across the blood-brain barrier by deletion of Slc38a5 causes developmental delay and motor dysfunction.
Title: Impairment of serine transport across the blood-brain barrier by deletion of Slc38a5 causes developmental delay and motor dysfunction.
Amino acid transporter SLC38A5 is a tumor promoter and a novel therapeutic target for pancreatic cancer.
Title: Amino acid transporter SLC38A5 is a tumor promoter and a novel therapeutic target for pancreatic cancer.
These results show that Slc38a5 is a key component of the feedback circuit between glucagon receptor signaling in the liver and amino-acid-dependent regulation of pancreatic alpha cell mass in mice.
Title: Amino Acid Transporter Slc38a5 Controls Glucagon Receptor Inhibition-Induced Pancreatic α Cell Hyperplasia in Mice.
ISH and IF revealed SN1 and SN2 expression in the ganglion, inner nuclear, and photoreceptor cell layers.
Title: Expression and function of system N glutamine transporters (SN1/SN2 or SNAT3/SNAT5) in retinal ganglion cells.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Gene trapped (1)
Targeted (1)

General gene information

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Markers

Slc38a5 (e-PCR), detects polymorphism
- UniSTS:547341

NoName (e-PCR)
- UniSTS:487467

RH127037 (e-PCR)
- UniSTS:209500

C81234 (e-PCR)
- UniSTS:160869

Slc38a5 (e-PCR), detects polymorphism
- UniSTS:508543

Slc38a5 (e-PCR), detects polymorphism
- UniSTS:525513

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-asparagine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-asparagine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-glutamine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-glutamine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-glutamine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-glutamine, sodium:proton antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-glutamine, sodium:proton antiporter activity	IEA Inferred from Electronic Annotation more info
enables L-glutamine, sodium:proton antiporter activity	ISO Inferred from Sequence Orthology more info
enables L-histidine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-histidine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-serine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-serine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables alanine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables alanine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables amino acid transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables glycine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables glycine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables neutral L-amino acid transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables neutral L-amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables neutral amino acid, sodium:proton antiporter activity	IEA Inferred from Electronic Annotation more info
enables neutral amino acid, sodium:proton antiporter activity	ISO Inferred from Sequence Orthology more info
enables neutral amino acid, sodium:proton antiporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in L-alanine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in L-alanine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in L-glutamine import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in L-glutamine import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in L-glutamine import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-histidine transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-histidine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in L-histidine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in L-serine import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in L-serine import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-serine import across plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in L-serine transport	IEA Inferred from Electronic Annotation more info
involved_in L-serine transport	ISO Inferred from Sequence Orthology more info
involved_in amino acid export across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in amino acid export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in amino acid export across plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in amino acid import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in amino acid import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in asparagine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in asparagine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in asparagine transport	IEA Inferred from Electronic Annotation more info
involved_in glutamine transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutamine transport	IEA Inferred from Electronic Annotation more info
involved_in glutamine transport	ISO Inferred from Sequence Orthology more info
involved_in glycine transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycine transport	IEA Inferred from Electronic Annotation more info
involved_in glycine transport	ISO Inferred from Sequence Orthology more info
involved_in neutral amino acid transport	IEA Inferred from Electronic Annotation more info
involved_in neutral amino acid transport	ISO Inferred from Sequence Orthology more info
involved_in neutral amino acid transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in serine transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in serine transport	IEA Inferred from Electronic Annotation more info
involved_in serine transport	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: sodium-coupled neutral amino acid transporter 5

Names: system N transporter 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172479.3 → NP_766067.2 sodium-coupled neutral amino acid transporter 5

See identical proteins and their annotated locations for NP_766067.2

Status: VALIDATED

Source sequence(s)

AK054485, AK158125, AL805902, BX523289

Consensus CDS

CCDS52990.1

UniProtKB/Swiss-Prot

Q3TZ39, Q3U1J0, Q8BJZ6, Q8BW30

Related

ENSMUSP00000033512.5, ENSMUST00000033512.11

Conserved Domains (2) summary

COG0814
Location:56 → 469

SdaC; Amino acid permease [Amino acid transport and metabolism]

cl00456
Location:56 → 466

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain