Format

Send to:

Choose Destination

Syt4 synaptotagmin IV [ Mus musculus (house mouse) ]

Gene ID: 20983, updated on 12-Aug-2018
Official Symbol
Syt4provided by MGI
Official Full Name
synaptotagmin IVprovided by MGI
Primary source
MGI:MGI:101759
See related
Ensembl:ENSMUSG00000024261
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SytIV
Summary
The protein encoded by this gene belongs to the synaptotagmin family. Members of this family are multi-domained, integral membrane proteins of synaptic vesicles, and are thought to serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis. This gene is primarily expressed in the nervous tissues. [provided by RefSeq, Jul 2008]
Expression
Biased expression in CNS E18 (RPKM 40.3), cerebellum adult (RPKM 32.9) and 5 other tissues See more
Orthologs
See Syt4 in Genome Data Viewer
Location:
18 B1; 18 17.75 cM
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 18 NC_000084.6 (31437808..31447415, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (31597462..31607069, complement)

Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 41681 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 pseudogene Neighboring gene actin, beta pseudogene Neighboring gene predicted gene, 38606

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SNARE binding ISO
Inferred from Sequence Orthology
more info
 
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium-dependent phospholipid binding IDA
Inferred from Direct Assay
more info
PubMed 
clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
clathrin binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylserine binding ISO
Inferred from Sequence Orthology
more info
 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
syntaxin binding ISO
Inferred from Sequence Orthology
more info
 
syntaxin-1 binding ISO
Inferred from Sequence Orthology
more info
 
syntaxin-3 binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
calcium ion regulated exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion-regulated exocytosis of neurotransmitter IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cellular response to calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
exocytosis IEA
Inferred from Electronic Annotation
more info
 
memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of calcium ion-dependent exocytosis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of catecholamine secretion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of dense core granule exocytosis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neurotransmitter secretion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of retrograde trans-synaptic signaling by neuropeptide IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of short-term neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of vesicle fusion ISO
Inferred from Sequence Orthology
more info
 
neurotransmitter secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of dendrite extension ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dense core granule exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of glutamate secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of calcium ion-dependent exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of calcium ion-dependent exocytosis TAS
Traceable Author Statement
more info
PubMed 
regulation of dopamine secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of dopamine secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
 
regulation of vesicle fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of vesicle fusion ISO
Inferred from Sequence Orthology
more info
 
secretory granule maturation ISO
Inferred from Sequence Orthology
more info
 
synaptic vesicle transport TAS
Traceable Author Statement
more info
PubMed 
vesicle fusion with vesicle ISO
Inferred from Sequence Orthology
more info
 
vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
astrocyte projection IDA
Inferred from Direct Assay
more info
PubMed 
astrocyte projection ISO
Inferred from Sequence Orthology
more info
 
axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
axon IDA
Inferred from Direct Assay
more info
PubMed 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
dense core granule IDA
Inferred from Direct Assay
more info
PubMed 
dense core granule ISO
Inferred from Sequence Orthology
more info
 
exocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
exocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
microvesicle IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
neuron projection terminus ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynapse NAS
Non-traceable Author Statement
more info
PubMed 
presynapse NAS
Non-traceable Author Statement
more info
PubMed 
secretory granule membrane ISO
Inferred from Sequence Orthology
more info
 
somatodendritic compartment IDA
Inferred from Direct Assay
more info
PubMed 
synapse IEA
Inferred from Electronic Annotation
more info
 
NOT synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
vesicle IDA
Inferred from Direct Assay
more info
PubMed 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009308.3NP_033334.2  synaptotagmin-4

    See identical proteins and their annotated locations for NP_033334.2

    Status: REVIEWED

    Source sequence(s)
    AK032106, CAAA01195961, CN666882
    Consensus CDS
    CCDS29109.1
    UniProtKB/Swiss-Prot
    P40749
    Related
    ENSMUSP00000025110.3, ENSMUST00000025110.3
    Conserved Domains (2) summary
    cd08388
    Location:153279
    C2A_Synaptotagmin-4-11; C2A domain first repeat present in Synaptotagmins 4 and 11
    cd08404
    Location:288423
    C2B_Synaptotagmin-4; C2 domain second repeat present in Synaptotagmin 4

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000084.6 Reference GRCm38.p4 C57BL/6J

    Range
    31437808..31447415 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317852.1XP_017173341.1  synaptotagmin-4 isoform X1

Support Center