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Syp synaptophysin [ Mus musculus (house mouse) ]

Gene ID: 20977, updated on 26-Sep-2022

Summary

Official Symbol
Sypprovided by MGI
Official Full Name
synaptophysinprovided by MGI
Primary source
MGI:MGI:98467
See related
Ensembl:ENSMUSG00000031144 AllianceGenome:MGI:98467
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Syn; p38; A230093K24Rik
Summary
Enables SH2 domain binding activity and identical protein binding activity. Involved in modulation of chemical synaptic transmission and synaptic vesicle endocytosis. Acts upstream of or within cellular response to organic substance. Located in several cellular components, including neuromuscular junction; presynaptic membrane; and synaptic vesicle membrane. Is active in Schaffer collateral - CA1 synapse. Is expressed in diaphragm; gut; nervous system; sensory organ; and skeletal muscle. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 96. Orthologous to human SYP (synaptophysin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 270.0), frontal lobe adult (RPKM 246.0) and 4 other tissues See more
Orthologs
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Genomic context

See Syp in Genome Data Viewer
Location:
X A1.1; X 3.44 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (7504819..7519495)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (7638580..7653256)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene forkhead box P3 Neighboring gene coiled-coil domain containing 22 Neighboring gene calcium channel, voltage-dependent, alpha 1F subunit Neighboring gene prickle planar cell polarity protein 3 Neighboring gene proteolipid protein 2 Neighboring gene MAGI family member, X-linked

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH2 domain binding IDA
Inferred from Direct Assay
more info
PubMed 
enables SNARE binding ISO
Inferred from Sequence Orthology
more info
 
enables cholesterol binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables syntaxin-1 binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in clathrin-sculpted glutamate transport vesicle membrane TAS
Traceable Author Statement
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in excitatory synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in excitatory synapse ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuromuscular junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection terminus IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection terminus ISO
Inferred from Sequence Orthology
more info
 
located_in neuron spine ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
located_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic active zone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in presynaptic active zone IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynaptic active zone ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle membrane TAS
Traceable Author Statement
more info
PubMed 
located_in terminal bouton IDA
Inferred from Direct Assay
more info
PubMed 
located_in terminal bouton ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
synaptophysin
Names
BM89 antigen
Syp I
major synaptic vesicle protein p38

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009305.2NP_033331.2  synaptophysin

    See identical proteins and their annotated locations for NP_033331.2

    Status: VALIDATED

    Source sequence(s)
    AI325251, AK043756, BC052354, BY239748
    Consensus CDS
    CCDS29967.2
    UniProtKB/Swiss-Prot
    Q62277, Q91WI8
    UniProtKB/TrEMBL
    A0A6P5NZK4
    Related
    ENSMUSP00000069429.5, ENSMUST00000069520.11
    Conserved Domains (1) summary
    pfam01284
    Location:22222
    MARVEL; Membrane-associating domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    7504819..7519495
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)