Syp synaptophysin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sypprovided by MGI
Official Full Name: synaptophysinprovided by MGI
Primary source: MGI:MGI:98467
See related: Ensembl:ENSMUSG00000031144 AllianceGenome:MGI:98467
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Syn; p38; A230093K24Rik
Summary: Enables SH2 domain binding activity and identical protein binding activity. Involved in modulation of chemical synaptic transmission and synaptic vesicle endocytosis. Acts upstream of or within cellular response to organic substance. Located in several cellular components, including neuromuscular junction; presynaptic membrane; and synaptic vesicle membrane. Is active in Schaffer collateral - CA1 synapse. Is expressed in diaphragm; gut; nervous system; sensory organ; and skeletal muscle. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 96. Orthologous to human SYP (synaptophysin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cortex adult (RPKM 270.0), frontal lobe adult (RPKM 246.0) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A1.1; X 3.44 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (7504819..7519495)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (7638580..7653256)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Multivalent electrostatic pi-cation interaction between synaptophysin and synapsin is responsible for the coacervation.
Title: Multivalent electrostatic pi-cation interaction between synaptophysin and synapsin is responsible for the coacervation.
Synaptophysin Regulates Fusion Pores and Exocytosis Mode in Chromaffin Cells.
Title: Synaptophysin Regulates Fusion Pores and Exocytosis Mode in Chromaffin Cells.
Ndufs4 ablation decreases synaptophysin expression in hippocampus.
Title: Ndufs4 ablation decreases synaptophysin expression in hippocampus.
Synaptophysin controls synaptobrevin-II retrieval via a cryptic C-terminal interaction site.
Title: Synaptophysin controls synaptobrevin-II retrieval via a cryptic C-terminal interaction site.
Cooperative function of synaptophysin and synapsin in the generation of synaptic vesicle-like clusters in non-neuronal cells.
Title: Cooperative function of synaptophysin and synapsin in the generation of synaptic vesicle-like clusters in non-neuronal cells.
Possible involvement of DNA methylation in hippocampal synaptophysin gene expression during postnatal development of mice.
Title: Possible involvement of DNA methylation in hippocampal synaptophysin gene expression during postnatal development of mice.
Central expression of synaptophysin and synaptoporin in nociceptive afferent subtypes in the dorsal horn.
Title: Central expression of synaptophysin and synaptoporin in nociceptive afferent subtypes in the dorsal horn.
Results suggest that the principal role of synaptophysin is to mediate the efficient retrieval of sybII to sustain neurotransmitter release
Title: Synaptophysin sustains presynaptic performance by preserving vesicular synaptobrevin-II levels.
decrease of vermian SYP1 and CNTN6 in reln(+/-) mice displayed patterns compatible with the structural modifications of the autistic cerebellum.
Title: Decreased Expression of Synaptophysin 1 (SYP1 Major Synaptic Vesicle Protein p38) and Contactin 6 (CNTN6/NB3) in the Cerebellar Vermis of reln Haplodeficient Mice.
Exendin-4 attenuates blast traumatic brain injury induced cognitive impairments, losses of synaptophysin and in vitro TBI-induced hippocampal cellular degeneration.
Title: Exendin-4 attenuates blast traumatic brain injury induced cognitive impairments, losses of synaptophysin and in vitro TBI-induced hippocampal cellular degeneration.

Submit: New GeneRIF Correction See all GeneRIFs (37)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Syp (e-PCR), detects polymorphism
- UniSTS:265752

AI848995 (e-PCR)
- UniSTS:166173

GDB:216846 (e-PCR)
- UniSTS:156218

DXImx21 (e-PCR), detects polymorphism
- UniSTS:186205

Syp (e-PCR), detects polymorphism
- UniSTS:144531

NoName (e-PCR)
- UniSTS:237994

G15886 (e-PCR)
- UniSTS:74686

X95818 (e-PCR)
- UniSTS:125899

Homology

Homologs of the Syp gene: The Syp gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, zebrafish, and frog.
Orthologs from Annotation Pipeline: 309 organisms have orthologs with human gene Syp
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SH2 domain binding	IDA Inferred from Direct Assay more info	PubMed
enables SNARE binding	ISO Inferred from Sequence Orthology more info
enables cholesterol binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables syntaxin-1 binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to organic substance	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within chemical synaptic transmission	TAS Traceable Author Statement more info	PubMed
involved_in endocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endocytosis	TAS Traceable Author Statement more info	PubMed
involved_in regulation of long-term neuronal synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuronal synaptic plasticity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of opioid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of short-term neuronal synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic vesicle exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in clathrin-sculpted glutamate transport vesicle membrane	TAS Traceable Author Statement more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in excitatory synapse	IDA Inferred from Direct Assay more info	PubMed
located_in excitatory synapse	ISO Inferred from Sequence Orthology more info
located_in intracellular organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IMP Inferred from Mutant Phenotype more info	PubMed
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuron projection terminus	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection terminus	ISO Inferred from Sequence Orthology more info
located_in neuron spine	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in presynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic active zone	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic active zone	ISO Inferred from Sequence Orthology more info	PubMed
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in synaptic vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle membrane	TAS Traceable Author Statement more info	PubMed
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed
located_in terminal bouton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: synaptophysin

Names: BM89 antigen; Syp I; major synaptic vesicle protein p38

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.