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Il23r interleukin 23 receptor [ Mus musculus (house mouse) ]

Gene ID: 209590, updated on 8-Feb-2024

Summary

Official Symbol
Il23rprovided by MGI
Official Full Name
interleukin 23 receptorprovided by MGI
Primary source
MGI:MGI:2181693
See related
Ensembl:ENSMUSG00000049093 AllianceGenome:MGI:2181693
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IL-23R
Summary
Predicted to enable cytokine binding activity and interleukin-23 receptor activity. Predicted to contribute to interleukin-12 receptor binding activity and interleukin-23 binding activity. Predicted to be involved in several processes, including positive regulation of defense response to virus by host; regulation of cytokine production; and response to interferon-gamma. Predicted to act upstream of or within leukocyte mediated immunity and receptor signaling pathway via JAK-STAT. Predicted to be integral component of plasma membrane. Predicted to be part of interleukin-23 receptor complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); inflammatory bowel disease (multiple); pulmonary hypertension; rhinitis; and systemic scleroderma. Orthologous to human IL23R (interleukin 23 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Il23r in Genome Data Viewer
Location:
6 C1; 6 30.85 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (67399906..67468838, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (67422932..67491855, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16185 Neighboring gene STARR-seq mESC enhancer starr_16186 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:67483136-67483367 Neighboring gene predicted gene, 44083 Neighboring gene ribosomal protein S7 pseudogene Neighboring gene immunoglobulin kappa chain variable 2-137 Neighboring gene tumor-associated calcium signal transducer 2 Neighboring gene immunoglobulin kappa chain complex

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (12)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to interleukin-12 receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to interleukin-12 receptor binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to interleukin-23 binding IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to interleukin-23 binding ISO
Inferred from Sequence Orthology
more info
 
enables interleukin-23 binding ISO
Inferred from Sequence Orthology
more info
PubMed 
contributes_to interleukin-23 receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables interleukin-23 receptor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within leukocyte mediated immunity ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in negative regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T-helper 1 type immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of defense response to virus by host ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-12 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
involved_in response to type II interferon ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of interleukin-23 receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of interleukin-23 receptor complex ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
interleukin-23 receptor
Names
IL-23 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144548.2NP_653131.3  interleukin-23 receptor precursor

    Status: VALIDATED

    Source sequence(s)
    AC124758, AC159129
    Consensus CDS
    CCDS39503.2
    UniProtKB/Swiss-Prot
    Q8K4B4
    UniProtKB/TrEMBL
    G5E8U4
    Related
    ENSMUSP00000113342.3, ENSMUST00000118364.2
    Conserved Domains (1) summary
    smart00060
    Location:125203
    FN3; Fibronectin type 3 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    67399906..67468838 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)