Il23r interleukin 23 receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il23rprovided by MGI
Official Full Name: interleukin 23 receptorprovided by MGI
Primary source: MGI:MGI:2181693
See related: Ensembl:ENSMUSG00000049093 AllianceGenome:MGI:2181693
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IL-23R
Summary: Predicted to enable cytokine binding activity and interleukin-23 receptor activity. Predicted to contribute to interleukin-12 receptor binding activity and interleukin-23 binding activity. Predicted to be involved in several processes, including positive regulation of defense response to virus by host; regulation of cytokine production; and response to interferon-gamma. Predicted to act upstream of or within leukocyte mediated immunity and receptor signaling pathway via JAK-STAT. Predicted to be integral component of plasma membrane. Predicted to be part of interleukin-23 receptor complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); inflammatory bowel disease (multiple); pulmonary hypertension; rhinitis; and systemic scleroderma. Orthologous to human IL23R (interleukin 23 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 6; 6 C1

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (67399916..67468839, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (67422932..67491855, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interleukin-23 receptor defines T helper 1-like regulatory T cells in oral squamous cell carcinoma.
Title: Interleukin-23 receptor defines T helper 1-like regulatory T cells in oral squamous cell carcinoma.
Interleukin-23 receptor expressing gammadelta T cells locally promote early atherosclerotic lesion formation and plaque necrosis in mice.
Title: Interleukin-23 receptor expressing γδ T cells locally promote early atherosclerotic lesion formation and plaque necrosis in mice.
Allergic airway inflammation induces upregulation of the expression of IL-23R by macrophages and not in CD3 + T cells and CD11c(+)F4/80(-) dendritic cells of the lung.
Title: Allergic airway inflammation induces upregulation of the expression of IL-23R by macrophages and not in CD3 + T cells and CD11c(+)F4/80(-) dendritic cells of the lung.
IL23R on myeloid cells is involved in murine pulmonary granuloma formation.
Title: IL23R on myeloid cells is involved in murine pulmonary granuloma formation.
IL-23 receptor deficiency results in lower bone mass via indirect regulation of bone formation.
Title: IL-23 receptor deficiency results in lower bone mass via indirect regulation of bone formation.
EBV-induced gene 3 augments IL-23Ralpha protein expression through a chaperone calnexin.
Title: EBV-induced gene 3 augments IL-23Rα protein expression through a chaperone calnexin.
ERalpha Signaling Increased IL-17A Production in Th17 Cells by Upregulating IL-23R Expression, Mitochondrial Respiration, and Proliferation.
Title: ERα Signaling Increased IL-17A Production in Th17 Cells by Upregulating IL-23R Expression, Mitochondrial Respiration, and Proliferation.
IL-23R-dependent T cell-mediated synovitis is dependent on CD4(+) CCR6(+) T cells and not on gammadelta T cells.
Title: CD4(+) CCR6(+) T cells, but not γδ T cells, are important for the IL-23R-dependent progression of antigen-induced inflammatory arthritis in mice.
To define the minimum signals required for development of encephalitogenic T cells that cause CNS autoimmunity, myelin-specific T cells were differentiated with various cytokine cocktails, and pathogenicity was determined by transfer into mice. IL-6+IL-23 or IL-12+IL-23 generated encephalitogenic T cells and recapitulated the essential cytokine signals provided by antigen-presenting cells, and both IL-6 and IL-12 induced
Title: IL-23R-activated STAT3/STAT4 is essential for Th1/Th17-mediated CNS autoimmunity.
Results suggest that the use of vectors carrying Soluble Interleukin-23 Receptor (sIL-23R) to block the interleukin-23/IL-23R interaction may be a new therapeutic strategy for the treatment of multiple sclerosis.
Title: Clinical and Histopathological Amelioration of Experimental Autoimmune Encephalomyelitis by AAV Vectors Expressing a Soluble Interleukin-23 Receptor.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (12) 1 citation
Endonuclease-mediated (3)

General gene information

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Homology

Homologs of the Il23r gene: The Il23r gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, and chicken.
Orthologs from Annotation Pipeline: 301 organisms have orthologs with human gene Il23r
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
contributes_to interleukin-12 receptor binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
contributes_to interleukin-12 receptor binding	ISO Inferred from Sequence Orthology more info
contributes_to interleukin-23 binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
contributes_to interleukin-23 binding	ISO Inferred from Sequence Orthology more info
enables interleukin-23 binding	ISO Inferred from Sequence Orthology more info	PubMed
contributes_to interleukin-23 receptor activity	ISO Inferred from Sequence Orthology more info
enables interleukin-23 receptor activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
involved_in immune response	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within leukocyte mediated immunity	ISO Inferred from Sequence Orthology more info	PubMed
involved_in negative regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NK T cell proliferation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 1 type immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 17 type immune response	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of defense response to virus by host	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-17 production	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info	PubMed
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in response to type II interferon	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of interleukin-23 receptor complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of interleukin-23 receptor complex	ISO Inferred from Sequence Orthology more info
part_of interleukin-23 receptor complex	NAS Non-traceable Author Statement more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: interleukin-23 receptor

Names: IL-23 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_144548.2 → NP_653131.3 interleukin-23 receptor precursor

Status: VALIDATED

Source sequence(s)

AC124758, AC159129

Consensus CDS

CCDS39503.2

UniProtKB/Swiss-Prot

Q8K4B4

Related

ENSMUSP00000113342.3, ENSMUST00000118364.2

Conserved Domains (1) summary

smart00060
Location:125 → 203

FN3; Fibronectin type 3 domain