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Trp53bp2 transformation related protein 53 binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 209456, updated on 8-Feb-2024

Summary

Official Symbol
Trp53bp2provided by MGI
Official Full Name
transformation related protein 53 binding protein 2provided by MGI
Primary source
MGI:MGI:2138319
See related
Ensembl:ENSMUSG00000026510 AllianceGenome:MGI:2138319
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
53BP2; ASPP2; Tp53bp2; PPP1R13A
Summary
Predicted to enable NF-kappaB binding activity; identical protein binding activity; and p53 binding activity. Acts upstream of or within several processes, including embryo development; heart development; and response to ionizing radiation. Predicted to be located in cell junction and cytosol. Predicted to be active in nucleus. Predicted to colocalize with perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study chromosome 1q41-q42 deletion syndrome. Orthologous to human TP53BP2 (tumor protein p53 binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 11.1), CNS E11.5 (RPKM 10.0) and 28 other tissues See more
Orthologs
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Genomic context

See Trp53bp2 in Genome Data Viewer
Location:
1 H5; 1 84.93 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (182236737..182289997)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (182409167..182462436)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene F-box protein 28 Neighboring gene STARR-seq mESC enhancer starr_03278 Neighboring gene STARR-positive B cell enhancer mm9_chr1:184271643-184271944 Neighboring gene STARR-positive B cell enhancer ABC_E5879 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E4402 Neighboring gene calpain 2 Neighboring gene STARR-seq mESC enhancer starr_03280 Neighboring gene predicted gene, 37885 Neighboring gene STARR-seq mESC enhancer starr_03281 Neighboring gene STARR-positive B cell enhancer mm9_chr1:184469487-184469788 Neighboring gene predicted gene, 46081 Neighboring gene GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NF-kappaB binding ISO
Inferred from Sequence Orthology
more info
 
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables p53 binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables p53 binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
apoptosis-stimulating of p53 protein 2
Names
p53-binding protein 2
p53BP2
tumor protein p53 binding protein, 2
tumor suppressor p53-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173378.3NP_775554.2  apoptosis-stimulating of p53 protein 2

    Status: VALIDATED

    Source sequence(s)
    AC131742
    Consensus CDS
    CCDS48476.1
    UniProtKB/Swiss-Prot
    Q3UYM7, Q8CG79, Q8K2L5
    UniProtKB/TrEMBL
    E9QJU8
    Related
    ENSMUSP00000112508.2, ENSMUST00000117245.2
    Conserved Domains (5) summary
    cd00204
    Location:9421053
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:9361022
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:936962
    ANK; ANK repeat [structural motif]
    cl00155
    Location:1790
    UBQ; Ubiquitin-like proteins
    cl17036
    Location:10661122
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    182236737..182289997
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)