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Tfe3 transcription factor E3 [ Mus musculus (house mouse) ]

Gene ID: 209446, updated on 17-Nov-2020

Summary

Official Symbol
Tfe3provided by MGI
Official Full Name
transcription factor E3provided by MGI
Primary source
MGI:MGI:98511
See related
Ensembl:ENSMUSG00000000134
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tcfe3; Tfe-3; mTFE3; bHLHe3; bHLHe33; F830016E06Rik
Expression
Ubiquitous expression in adrenal adult (RPKM 12.2), genital fat pad adult (RPKM 11.2) and 28 other tissues See more
Orthologs

Genomic context

See Tfe3 in Genome Data Viewer
Location:
X A1.1; X 3.5 cM
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (7628769..7641441)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (7762530..7775202)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (7339787..7352328)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 120 Neighboring gene SMT3 suppressor of mif two 3 homolog 2, pseudogene (S. cerevisiae) Neighboring gene predicted gene, 39487 Neighboring gene GRIP1 associated protein 1 Neighboring gene microRNA 1198 Neighboring gene potassium voltage-gated channel, Shal-related family, member 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
cytoplasm IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
transcription regulator complex IC
Inferred by Curator
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105196.1NP_001098666.1  transcription factor E3 isoform b

    See identical proteins and their annotated locations for NP_001098666.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AK139756, AL671995, BC056358
    Consensus CDS
    CCDS52985.1
    UniProtKB/Swiss-Prot
    Q64092
    UniProtKB/TrEMBL
    A2AEW0
    Related
    ENSMUSP00000078498.6, ENSMUST00000079542.12
    Conserved Domains (3) summary
    cd00083
    Location:308368
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam11851
    Location:466535
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:112260
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
  2. NM_001105197.1NP_001098667.1  transcription factor E3 isoform c

    See identical proteins and their annotated locations for NP_001098667.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a. Variants 3, 4, and 5 encode the same isoform (c).
    Source sequence(s)
    AK152221, BC056358, BY208269
    Consensus CDS
    CCDS72332.1
    UniProtKB/Swiss-Prot
    Q64092
    Related
    ENSMUSP00000111341.1, ENSMUST00000115677.7
    Conserved Domains (3) summary
    pfam11851
    Location:326465
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:7160
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
    cd18928
    Location:231321
    bHLHzip_TFE3; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor E3 (TFE3) and similar proteins
  3. NM_001271489.1NP_001258418.1  transcription factor E3 isoform c

    See identical proteins and their annotated locations for NP_001258418.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site at an internal exon, compared to variant 1, and initiates translation at a downstream in-frame start codon. The encoded isoform (c) has a shorter N-terminus, compared to isoform a. Variants 3, 4, and 5 encode the same isoform (c).
    Source sequence(s)
    AK159162, AL671995, BC056358
    Consensus CDS
    CCDS72332.1
    UniProtKB/Swiss-Prot
    Q64092
    Related
    ENSMUSP00000111343.1, ENSMUST00000115679.7
    Conserved Domains (3) summary
    pfam11851
    Location:326465
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:7160
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
    cd18928
    Location:231321
    bHLHzip_TFE3; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor E3 (TFE3) and similar proteins
  4. NM_001271490.1NP_001258419.1  transcription factor E3 isoform c

    See identical proteins and their annotated locations for NP_001258419.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 5' exon, compared to variant 1, and initiates translation at a downstream in-frame start codon. The encoded isoform (c) has a shorter N-terminus, compared to isoform a. Variants 3, 4, and 5 encode the same isoform (c).
    Source sequence(s)
    AK139756, AL671995, BC056358
    Consensus CDS
    CCDS72332.1
    UniProtKB/Swiss-Prot
    Q64092
    Related
    ENSMUSP00000134125.1, ENSMUST00000137467.7
    Conserved Domains (3) summary
    pfam11851
    Location:326465
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:7160
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
    cd18928
    Location:231321
    bHLHzip_TFE3; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor E3 (TFE3) and similar proteins
  5. NM_001271491.1NP_001258420.1  transcription factor E3 isoform d

    See identical proteins and their annotated locations for NP_001258420.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, has multiple differences in the coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
    Source sequence(s)
    AK155883, BC063047
    Consensus CDS
    CCDS72333.1
    UniProtKB/Swiss-Prot
    Q64092
    UniProtKB/TrEMBL
    Q3U1L5
    Related
    ENSMUSP00000111342.2, ENSMUST00000115678.2
    Conserved Domains (3) summary
    pfam11851
    Location:291430
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:7155
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
    cd18928
    Location:196286
    bHLHzip_TFE3; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor E3 (TFE3) and similar proteins
  6. NM_172472.3NP_766060.2  transcription factor E3 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AF510653, AL671995, BC056358
    Consensus CDS
    CCDS52984.1
    UniProtKB/Swiss-Prot
    Q64092
    UniProtKB/TrEMBL
    A2AEW1, Q8K420
    Related
    ENSMUSP00000076864.3, ENSMUST00000077680.9
    Conserved Domains (3) summary
    cd00083
    Location:343403
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam11851
    Location:518570
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:112264
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    7628769..7641441
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527578.3XP_006527641.1  transcription factor E3 isoform X1

    See identical proteins and their annotated locations for XP_006527641.1

    UniProtKB/Swiss-Prot
    Q64092
    Conserved Domains (3) summary
    pfam11851
    Location:326465
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:7160
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
    cd18928
    Location:231321
    bHLHzip_TFE3; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor E3 (TFE3) and similar proteins
  2. XM_036161900.1XP_036017793.1  transcription factor E3 isoform X2

    Conserved Domains (3) summary
    pfam11851
    Location:291430
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:7155
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
    cd18928
    Location:196286
    bHLHzip_TFE3; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor E3 (TFE3) and similar proteins
  3. XM_017318454.3XP_017173943.1  transcription factor E3 isoform X2

    UniProtKB/Swiss-Prot
    Q64092
    Conserved Domains (3) summary
    pfam11851
    Location:291430
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:7155
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
    cd18928
    Location:196286
    bHLHzip_TFE3; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor E3 (TFE3) and similar proteins
  4. XM_017318453.3XP_017173942.1  transcription factor E3 isoform X1

    UniProtKB/Swiss-Prot
    Q64092
    Conserved Domains (3) summary
    pfam11851
    Location:326465
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:7160
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
    cd18928
    Location:231321
    bHLHzip_TFE3; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor E3 (TFE3) and similar proteins
  5. XM_036161898.1XP_036017791.1  transcription factor E3 isoform X1

    Conserved Domains (3) summary
    pfam11851
    Location:326465
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:7160
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
    cd18928
    Location:231321
    bHLHzip_TFE3; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor E3 (TFE3) and similar proteins
  6. XM_036161899.1XP_036017792.1  transcription factor E3 isoform X1

    Conserved Domains (3) summary
    pfam11851
    Location:326465
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:7160
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
    cd18928
    Location:231321
    bHLHzip_TFE3; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor E3 (TFE3) and similar proteins

RNA

  1. XR_003953006.1 RNA Sequence

    Related
    ENSMUST00000115680.10
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