Format

Send to:

Choose Destination

Suv39h1 suppressor of variegation 3-9 1 [ Mus musculus (house mouse) ]

Gene ID: 20937, updated on 2-Oct-2018

Summary

Official Symbol
Suv39h1provided by MGI
Official Full Name
suppressor of variegation 3-9 1provided by MGI
Primary source
MGI:MGI:1099440
See related
Ensembl:ENSMUSG00000039231 Vega:OTTMUSG00000017258
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mIS6; KMT1A; AI852103; AL022883; DXHXS7466e; H3-K9-HMTase 1
Expression
Ubiquitous expression in thymus adult (RPKM 16.1), CNS E11.5 (RPKM 15.8) and 28 other tissues See more
Orthologs

Genomic context

See Suv39h1 in Genome Data Viewer
Location:
X A1.1; X 3.64 cM
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (8061171..8074760, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (7638297..7651886, complement)

Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L22, pseudogene 1 Neighboring gene ribosomal protein S29 pseudogene Neighboring gene Wiskott-Aldrich syndrome Neighboring gene proteasome (prosome, macropain) subunit, beta type 7 pseudogene Neighboring gene proteasome (prosome, macropain) subunit, beta type 7, pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
RNA polymerase II regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
S-adenosylmethionine-dependent methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
histone methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
histone methyltransferase activity (H3-K9 specific) IDA
Inferred from Direct Assay
more info
PubMed 
histone methyltransferase activity (H3-K9 specific) ISO
Inferred from Sequence Orthology
more info
PubMed 
histone-lysine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
histone-lysine N-methyltransferase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
histone-lysine N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein N-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein methyltransferase activity TAS
Traceable Author Statement
more info
PubMed 
transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA packaging TAS
Traceable Author Statement
more info
PubMed 
blastocyst hatching IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
PubMed 
chromatin organization IEA
Inferred from Electronic Annotation
more info
 
chromatin silencing TAS
Traceable Author Statement
more info
PubMed 
chromatin silencing at rDNA ISO
Inferred from Sequence Orthology
more info
 
determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
PubMed 
histone H3-K9 dimethylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone H3-K9 methylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H3-K9 methylation IGI
Inferred from Genetic Interaction
more info
PubMed 
histone H3-K9 trimethylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone lysine methylation IGI
Inferred from Genetic Interaction
more info
PubMed 
methylation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of histone H3-K9 trimethylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
rRNA processing IEA
Inferred from Electronic Annotation
more info
 
regulation of DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of bone mineralization IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of cellular senescence IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of multicellular organism growth IGI
Inferred from Genetic Interaction
more info
PubMed 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
chromatin silencing complex IDA
Inferred from Direct Assay
more info
PubMed 
chromatin silencing complex ISO
Inferred from Sequence Orthology
more info
 
chromosome IEA
Inferred from Electronic Annotation
more info
 
chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
heterochromatin ISO
Inferred from Sequence Orthology
more info
 
nuclear heterochromatin TAS
Traceable Author Statement
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
rDNA heterochromatin ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
histone-lysine N-methyltransferase SUV39H1
Names
Suv39h histone methyltransferase
histone H3-K9 methyltransferase 1
position-effect variegation 3-9 homolog
su(var)3-9 homolog 1
suppressor of variegation 3-9 homolog 1
NP_001277645.1
NP_035644.1
XP_006527637.1
XP_011245754.1
XP_011245755.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290716.1NP_001277645.1  histone-lysine N-methyltransferase SUV39H1 isoform 2

    See identical proteins and their annotated locations for NP_001277645.1

    Status: VALIDATED

    Source sequence(s)
    AK021174, AK169389, AL663032
    Consensus CDS
    CCDS72337.1
    UniProtKB/Swiss-Prot
    O54864
    UniProtKB/TrEMBL
    A2AC19
    Related
    ENSMUSP00000111300.1, OTTMUSP00000018772, ENSMUST00000115637.7, OTTMUST00000041763
    Conserved Domains (3) summary
    smart00468
    Location:133228
    PreSET; N-terminal to some SET domains
    smart00317
    Location:244367
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam00385
    Location:4592
    Chromo; Chromo (CHRromatin Organization MOdifier) domain
  2. NM_011514.2NP_035644.1  histone-lysine N-methyltransferase SUV39H1 isoform 1

    See identical proteins and their annotated locations for NP_035644.1

    Status: VALIDATED

    Source sequence(s)
    AK169389, AL663032, BU053459
    Consensus CDS
    CCDS40846.1
    UniProtKB/Swiss-Prot
    O54864
    Related
    ENSMUSP00000111301.3, OTTMUSP00000018771, ENSMUST00000115638.9, OTTMUST00000041762
    Conserved Domains (3) summary
    smart00468
    Location:132227
    PreSET; N-terminal to some SET domains
    smart00317
    Location:243366
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam00385
    Location:4491
    Chromo; Chromo (CHRromatin Organization MOdifier) domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

    Range
    8061171..8074760 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247453.2XP_011245755.1  histone-lysine N-methyltransferase SUV39H1 isoform X3

    Conserved Domains (3) summary
    smart00468
    Location:133228
    PreSET; N-terminal to some SET domains
    smart00317
    Location:244367
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam00385
    Location:4592
    Chromo; Chromo (CHRromatin Organization MOdifier) domain
  2. XM_006527574.3XP_006527637.1  histone-lysine N-methyltransferase SUV39H1 isoform X2

    Conserved Domains (3) summary
    smart00468
    Location:132227
    PreSET; N-terminal to some SET domains
    smart00317
    Location:243366
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam00385
    Location:4491
    Chromo; Chromo (CHRromatin Organization MOdifier) domain
  3. XM_011247452.2XP_011245754.1  histone-lysine N-methyltransferase SUV39H1 isoform X1

    Conserved Domains (3) summary
    smart00468
    Location:133228
    PreSET; N-terminal to some SET domains
    smart00317
    Location:244367
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam00385
    Location:4592
    Chromo; Chromo (CHRromatin Organization MOdifier) domain
Support Center