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Taf3 TATA-box binding protein associated factor 3 [ Mus musculus (house mouse) ]

Gene ID: 209361, updated on 9-May-2024

Summary

Official Symbol
Taf3provided by MGI
Official Full Name
TATA-box binding protein associated factor 3provided by MGI
Primary source
MGI:MGI:2388097
See related
Ensembl:ENSMUSG00000025782 AllianceGenome:MGI:2388097
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
140kDa; TAF140; TAFII140; TAFII-140; mTAFII140; 4933439M23Rik
Summary
Enables p53 binding activity and transcription regulator inhibitor activity. Involved in negative regulation of DNA-binding transcription factor activity and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including eye; genitourinary system; heart; nervous system; and respiratory system. Orthologous to human TAF3 (TATA-box binding protein associated factor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 3.3), testis adult (RPKM 3.1) and 28 other tissues See more
Orthologs
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Genomic context

See Taf3 in Genome Data Viewer
Location:
2 A1; 2 6.74 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (9919363..10053420, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (9914552..10048609, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 54101 Neighboring gene STARR-seq mESC enhancer starr_03630 Neighboring gene GATA binding protein 3 Neighboring gene GATA binding protein 3 opposite strand Neighboring gene STARR-seq mESC enhancer starr_03633 Neighboring gene Gata3 upstream neighbor Neighboring gene STARR-seq mESC enhancer starr_03634 Neighboring gene predicted gene 13262 Neighboring gene predicted gene, 31290 Neighboring gene predicted gene, 54137 Neighboring gene STARR-positive B cell enhancer ABC_E11119 Neighboring gene ATP synthase F1 subunit gamma Neighboring gene predicted gene, 23608 Neighboring gene Kin17 DNA and RNA binding protein

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables p53 binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables p53 binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription regulator inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription factor TFIID complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of transcription factor TFIID complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
transcription initiation factor TFIID subunit 3
Names
140 kDa TATA box-binding protein-associated factor
RNA polymerase II transcription factor, TFIID subunit
TAF(II)140
TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa
TBP-associated factor 3
transcription initiation factor TFIID 140 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027748.3NP_082024.2  transcription initiation factor TFIID subunit 3

    See identical proteins and their annotated locations for NP_082024.2

    Status: VALIDATED

    Source sequence(s)
    AK136045, AW049595, BB621106, BC137618, CX763644
    Consensus CDS
    CCDS15675.1
    UniProtKB/Swiss-Prot
    Q3U490, Q3UWX2, Q5HZG4, Q8BIU8, Q99JH4
    UniProtKB/TrEMBL
    A2ASY0, A2ASY1
    Related
    ENSMUSP00000026888.5, ENSMUST00000026888.11
    Conserved Domains (3) summary
    smart00576
    Location:579
    BTP; Bromodomain transcription factors and PHD domain containing proteins
    cd15522
    Location:869914
    PHD_TAF3; PHD finger found in transcription initiation factor TFIID subunit 3 (TAF3)
    pfam16294
    Location:607656
    RSB_motif; RNSP1-SAP18 binding (RSB) motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    9919363..10053420 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)