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Gtf2h3 general transcription factor IIH, polypeptide 3 [ Mus musculus (house mouse) ]

Gene ID: 209357, updated on 30-Apr-2024

Summary

Official Symbol
Gtf2h3provided by MGI
Official Full Name
general transcription factor IIH, polypeptide 3provided by MGI
Primary source
MGI:MGI:1277143
See related
Ensembl:ENSMUSG00000029387 AllianceGenome:MGI:1277143
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BTF2; 34kDa; TFIIH; BTF2 p34; C730029A10; D5Ertd679e; 5033417D07Rik
Summary
Predicted to enable RNA polymerase II general transcription initiation factor activity and protein N-terminus binding activity. Predicted to be involved in nucleotide-excision repair; phosphorylation of RNA polymerase II C-terminal domain; and transcription by RNA polymerase II. Predicted to act upstream of or within DNA repair. Predicted to be located in nucleoplasm. Predicted to be part of core TFIIH complex portion of holo TFIIH complex; transcription factor TFIID complex; and transcription preinitiation complex. Is expressed in several structures, including blastocyst; genitourinary system; and submandibular gland primordium. Orthologous to human GTF2H3 (general transcription factor IIH subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 13.8), limb E14.5 (RPKM 12.9) and 28 other tissues See more
Orthologs
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Genomic context

See Gtf2h3 in Genome Data Viewer
Location:
5 F; 5 63.67 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (124717211..124735743)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (124579148..124597680)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3620 Neighboring gene DEAD box helicase 55 Neighboring gene STARR-positive B cell enhancer ABC_E8083 Neighboring gene eukaryotic translation initiation factor 2B, subunit alpha Neighboring gene STARR-positive B cell enhancer ABC_E10353 Neighboring gene tectonic family member 2 Neighboring gene STARR-seq mESC enhancer starr_14344 Neighboring gene STARR-positive B cell enhancer mm9_chr5:125079413-125079714 Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit A2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II general transcription initiation factor activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of core TFIIH complex portion of holo TFIIH complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription factor TFIID complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription factor TFIIH core complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of transcription factor TFIIH holo complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of transcription factor TFIIH holo complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription preinitiation complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
general transcription factor IIH subunit 3
Names
BTF2-p34
TFIIH basal transcription factor complex p34 subunit
basic transcription factor 2 34 kDa subunit
general transcription factor IIH, polypeptide 3, 34kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181410.3NP_852075.1  general transcription factor IIH subunit 3

    See identical proteins and their annotated locations for NP_852075.1

    Status: VALIDATED

    Source sequence(s)
    AK050227, AK133941, BB637936
    Consensus CDS
    CCDS19680.1
    UniProtKB/Swiss-Prot
    Q8VD76
    UniProtKB/TrEMBL
    Q3UZB8
    Related
    ENSMUSP00000031333.4, ENSMUST00000031333.4
    Conserved Domains (1) summary
    TIGR00627
    Location:7290
    tfb4; transcription factor tfb4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    124717211..124735743
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)