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Gps1 G protein pathway suppressor 1 [ Mus musculus (house mouse) ]

Gene ID: 209318, updated on 26-Sep-2022

Summary

Official Symbol
Gps1provided by MGI
Official Full Name
G protein pathway suppressor 1provided by MGI
Primary source
MGI:MGI:2384801
See related
Ensembl:ENSMUSG00000025156 AllianceGenome:MGI:2384801
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Csn1; Sgn1; Cops1
Summary
Predicted to be involved in protein deneddylation. Part of COP9 signalosome. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; hemolymphoid system gland; and retina. Orthologous to human GPS1 (G protein pathway suppressor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 101.5), testis adult (RPKM 81.3) and 28 other tissues See more
Orthologs
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Genomic context

See Gps1 in Genome Data Viewer
Location:
11; 11 E2
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120675086..120679928)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120784260..120789102)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene NADPH-dependent carbonyl reductase pseudogene Neighboring gene RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Neighboring gene dihydrouridine synthase 1-like (S. cerevisiae) Neighboring gene fatty acid synthase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC7191, MGC118012

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in protein deneddylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of COP9 signalosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of COP9 signalosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of COP9 signalosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
COP9 signalosome complex subunit 1
Names
JAB1-containing signalosome subunit 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177874.2NP_001171345.1  COP9 signalosome complex subunit 1 isoform 2

    See identical proteins and their annotated locations for NP_001171345.1

    Status: VALIDATED

    Source sequence(s)
    AL663090
    Consensus CDS
    CCDS49011.1
    UniProtKB/TrEMBL
    A0A6P5QRH4, Q3MIA8
    Related
    ENSMUSP00000112007.2, ENSMUST00000116305.8
    Conserved Domains (2) summary
    pfam01399
    Location:320424
    PCI; PCI domain
    pfam10602
    Location:123305
    RPN7; 26S proteasome subunit RPN7
  2. NM_001346709.2NP_001333638.1  COP9 signalosome complex subunit 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL663090
    Consensus CDS
    CCDS83950.1
    UniProtKB/TrEMBL
    A0A6P5QDM0, B1ATU4
    Related
    ENSMUSP00000097711.4, ENSMUST00000100134.10
    Conserved Domains (2) summary
    pfam01399
    Location:320424
    PCI; PCI domain
    pfam10602
    Location:123305
    RPN7; 26S proteasome subunit RPN7
  3. NM_001363440.1NP_001350369.1  COP9 signalosome complex subunit 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL663090
    Consensus CDS
    CCDS88299.1
    UniProtKB/TrEMBL
    A0A140LJB7, A0A6P5QK82
    Related
    ENSMUSP00000147152.2, ENSMUST00000208737.2
    Conserved Domains (2) summary
    pfam01399
    Location:319423
    PCI; PCI domain
    pfam10602
    Location:123304
    RPN7; 26S proteasome subunit RPN7
  4. NM_001405272.1NP_001392201.1  COP9 signalosome complex subunit 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL663090
  5. NM_001405273.1NP_001392202.1  COP9 signalosome complex subunit 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL663090
  6. NM_001405274.1NP_001392203.1  COP9 signalosome complex subunit 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL663090
  7. NM_001405275.1NP_001392204.1  COP9 signalosome complex subunit 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL663090
    UniProtKB/TrEMBL
    A0A6P5QKH0
  8. NM_145370.4NP_663345.2  COP9 signalosome complex subunit 1 isoform 1

    See identical proteins and their annotated locations for NP_663345.2

    Status: VALIDATED

    Source sequence(s)
    AL663090
    Consensus CDS
    CCDS25758.2
    UniProtKB/TrEMBL
    A0A6P5QM72, A0A8C6I471, G3UXW9
    Related
    ENSMUSP00000133855.2, ENSMUST00000172809.2
    Conserved Domains (2) summary
    pfam01399
    Location:359463
    PCI; PCI domain
    pfam10602
    Location:162344
    RPN7; 26S proteasome subunit RPN7

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    120675086..120679928
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314411.1XP_017169900.1  COP9 signalosome complex subunit 1 isoform X4

    Conserved Domains (2) summary
    pfam01399
    Location:319423
    PCI; PCI domain
    pfam10602
    Location:123304
    RPN7; 26S proteasome subunit RPN7
  2. XM_006532744.3XP_006532807.1  COP9 signalosome complex subunit 1 isoform X1

    Conserved Domains (2) summary
    pfam01399
    Location:359463
    PCI; PCI domain
    pfam10602
    Location:162344
    RPN7; 26S proteasome subunit RPN7
  3. XM_017314409.2XP_017169898.1  COP9 signalosome complex subunit 1 isoform X2

    Conserved Domains (2) summary
    pfam01399
    Location:358462
    PCI; PCI domain
    pfam10602
    Location:162343
    RPN7; 26S proteasome subunit RPN7
  4. XM_017314410.3XP_017169899.1  COP9 signalosome complex subunit 1 isoform X3

    Conserved Domains (2) summary
    pfam01399
    Location:358462
    PCI; PCI domain
    pfam10602
    Location:162343
    RPN7; 26S proteasome subunit RPN7