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Dtx3l deltex 3-like, E3 ubiquitin ligase [ Mus musculus (house mouse) ]

Gene ID: 209200, updated on 8-Feb-2024

Summary

Official Symbol
Dtx3lprovided by MGI
Official Full Name
deltex 3-like, E3 ubiquitin ligaseprovided by MGI
Primary source
MGI:MGI:2656973
See related
Ensembl:ENSMUSG00000049502 AllianceGenome:MGI:2656973
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable several functions, including STAT family protein binding activity; ubiquitin protein ligase activity; and ubiquitin-like protein ligase binding activity. Predicted to be involved in several processes, including positive regulation of macromolecule metabolic process; positive regulation of protein localization; and protein ubiquitination. Predicted to act upstream of or within several processes, including DNA repair; chromatin organization; and defense response to other organism. Predicted to be located in cytosol; lysosome; and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in nucleoplasm. Predicted to colocalize with early endosome. Is expressed in several structures, including brain; genitourinary system; gut; immune system; and oral cavity. Orthologous to human DTX3L (deltex E3 ubiquitin ligase 3L). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in large intestine adult (RPKM 10.6), thymus adult (RPKM 6.4) and 25 other tissues See more
Orthologs
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Genomic context

See Dtx3l in Genome Data Viewer
Location:
16 B3; 16 25.43 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (35746885..35759397, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (35926515..35939027, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41467 Neighboring gene STARR-seq mESC enhancer starr_40750 Neighboring gene 60S ribosomal protein L35a pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E4168 Neighboring gene poly (ADP-ribose) polymerase family, member 9 Neighboring gene STARR-seq mESC enhancer starr_40752 Neighboring gene predicted gene 15564 Neighboring gene karyopherin subunit alpha 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC103262

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables STAT family protein binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables histone H4K91 ubiquitin ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables histone binding ISO
Inferred from Sequence Orthology
more info
 
enables histone ubiquitin ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein ADP-ribosyltransferase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin-like protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair-dependent chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within defense response to virus IEA
Inferred from Electronic Annotation
more info
 
involved_in double-strand break repair ISO
Inferred from Sequence Orthology
more info
 
involved_in endosome to lysosome transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chromatin binding ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of defense response to virus by host ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to early endosome ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase DTX3L
Names
RING-type E3 ubiquitin transferase DTX3L
NP_001013389.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013371.2NP_001013389.2  E3 ubiquitin-protein ligase DTX3L

    See identical proteins and their annotated locations for NP_001013389.2

    Status: VALIDATED

    Source sequence(s)
    AC129574, AK146802, CN668148
    Consensus CDS
    CCDS37325.1
    UniProtKB/Swiss-Prot
    Q3UIR3, Q8BN11
    UniProtKB/TrEMBL
    I6L9G8
    Related
    ENSMUSP00000080601.8, ENSMUST00000081933.14
    Conserved Domains (3) summary
    cd09633
    Location:616746
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd00162
    Location:569607
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd12300
    Location:886
    RRM1_PAR14; RNA recognition motif 1 in vertebrate poly [ADP-ribose] polymerase 14 (PARP-14)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    35746885..35759397 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)