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Suclg2 succinate-Coenzyme A ligase, GDP-forming, beta subunit [ Mus musculus (house mouse) ]

Gene ID: 20917, updated on 8-Nov-2022

Summary

Official Symbol
Suclg2provided by MGI
Official Full Name
succinate-Coenzyme A ligase, GDP-forming, beta subunitprovided by MGI
Primary source
MGI:MGI:1306824
See related
Ensembl:ENSMUSG00000061838 AllianceGenome:MGI:1306824
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G-SCS; GTPSCS; D6Wsu120e; SCS-betaG
Summary
Predicted to enable succinate-CoA ligase (GDP-forming) activity and succinate-semialdehyde dehydrogenase (NAD+) activity. Predicted to be involved in succinyl-CoA metabolic process and tricarboxylic acid cycle. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human SUCLG2 (succinate-CoA ligase GDP-forming subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 29.5), liver adult (RPKM 17.1) and 27 other tissues See more
Orthologs
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Genomic context

See Suclg2 in Genome Data Viewer
Location:
6 D2; 6 44.63 cM
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (95449990..95695850, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (95473009..95718858, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene cDNA sequence AY512915 Neighboring gene predicted gene, 53325 Neighboring gene predicted gene, 32009 Neighboring gene predicted gene, 38864

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC91183

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables GDP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
NOT enables succinate-CoA ligase (ADP-forming) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables succinate-CoA ligase (GDP-forming) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables succinate-CoA ligase (GDP-forming) activity ISO
Inferred from Sequence Orthology
more info
 
enables succinate-semialdehyde dehydrogenase (NAD+) activity ISA
Inferred from Sequence Alignment
more info
PubMed 
Process Evidence Code Pubs
involved_in succinate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in succinyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in succinyl-CoA metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in tricarboxylic acid cycle ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of succinate-CoA ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of succinate-CoA ligase complex (GDP-forming) IGI
Inferred from Genetic Interaction
more info
PubMed 
part_of succinate-CoA ligase complex (GDP-forming) ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial
Names
GTP-specific succinyl-CoA synthetase beta subunit
succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial
succinyl-CoA synthetase beta-G chain
NP_001313487.1
NP_035637.2
XP_030111155.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001326558.2NP_001313487.1  succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC121612, AC125225, AC135018
    Consensus CDS
    CCDS85100.1
    UniProtKB/Swiss-Prot
    Q9Z2I8
    Related
    ENSMUSP00000078774.7, ENSMUST00000079847.8
    Conserved Domains (3) summary
    PRK00696
    Location:2372
    sucC; succinyl-CoA synthetase subunit beta; Provisional
    pfam00549
    Location:258372
    Ligase_CoA; CoA-ligase
    pfam08442
    Location:1199
    ATP-grasp_2; ATP-grasp domain
  2. NM_001410411.1NP_001397340.1  succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC121612, AC125225, AC135018
  3. NM_011507.4NP_035637.2  succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_035637.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC121612, AC125225, AC135018
    Consensus CDS
    CCDS20381.1
    UniProtKB/Swiss-Prot
    Q8K2K9, Q9Z2I8
    Related
    ENSMUSP00000144827.2, ENSMUST00000204224.3
    Conserved Domains (3) summary
    PRK00696
    Location:40421
    sucC; succinyl-CoA synthetase subunit beta; Provisional
    pfam00549
    Location:307421
    Ligase_CoA; CoA-ligase
    pfam08442
    Location:40248
    ATP-grasp_2; ATP-grasp domain

RNA

  1. NR_177067.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC121612, AC125225, AC135018
  2. NR_177068.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC121612, AC125225, AC135018
  3. NR_177069.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC121612, AC125225, AC135018

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    95449990..95695850 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255295.1XP_030111155.1  succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial isoform X1

    Conserved Domains (1) summary
    cl29683
    Location:1301
    sucC; ADP-forming succinate--CoA ligase subunit beta

RNA

  1. XR_003956174.2 RNA Sequence