Stxbp3 syntaxin binding protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stxbp3provided by MGI
Official Full Name: syntaxin binding protein 3provided by MGI
Primary source: MGI:MGI:107362
See related: Ensembl:ENSMUSG00000027882 AllianceGenome:MGI:107362
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sxtbp3; Stxbp3a; Unc18-3; Munc-18c
Summary: Enables syntaxin binding activity. Acts upstream of or within several processes, including cellular response to interferon-gamma; negative regulation of glucose import; and secretion by cell. Located in apical plasma membrane; cytosol; and phagocytic vesicle. Is expressed in embryo. Orthologous to human STXBP3 (syntaxin binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 13.8), placenta adult (RPKM 11.4) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3; 3 F3

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (108700496..108747818, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (108793180..108840502, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

microRNA-15b contributes to depression-like behavior in mice by affecting synaptic protein levels and function in the nucleus accumbens.
Title: microRNA-15b contributes to depression-like behavior in mice by affecting synaptic protein levels and function in the nucleus accumbens.
Pancreatic acini from Munc18c-depleted mice (Munc18c(+/-)) and human pancreas (lenti-Munc18c-shRNA-treated) exhibit normal apical exocytosis of zymogen granules (ZGs) in response to physiologic stimulation with the intestinal hormone cholecystokinin (CCK-8).
Title: Depletion of the membrane-fusion regulator Munc18c attenuates caerulein hyperstimulation-induced pancreatitis.
observed an almost complete absence of exocytosis in Munc18-2-deficient MCs but intact exocytosis in MCs lacking Munc18-1 or Munc18-3
Title: Munc18-2, but not Munc18-1 or Munc18-3, controls compound and single-vesicle-regulated exocytosis in mast cells.
Investigated the use of Escherichia coli as an expression host for Munc18c. Three N-terminal His-tagged constructs were engineered, two with a tobacco etch virus (TEV) or thrombin protease cleavage site to enable removal of the fusion tag.
Title: Milligram quantities of homogeneous recombinant full-length mouse Munc18c from Escherichia coli cultures.
PTP1B is the first known tyrosine phosphatase for Munc18c and a regulator of its phosphorylation and function in adipocytes.
Title: Regulation of the SNARE-interacting protein Munc18c tyrosine phosphorylation in adipocytes by protein-tyrosine phosphatase 1B.
Ectopic expression of syntaxin3 affects behaviors of B16 melanoma by controlling actin dynamics.
Title: Ectopic expression of syntaxin3 affects behaviors of B16 melanoma by controlling actin dynamics.
Munc18c provides stimulus-specific regulation of GLUT4 trafficking, but not FA transporter trafficking
Title: Munc18c provides stimulus-selective regulation of GLUT4 but not fatty acid transporter trafficking in skeletal muscle.
The Using 3T3-L1 adipocytes subjected to small interfering ribonucleic acid reduction of Munc18c as a model of impaired insulin-stimulated GLUT4 vesicle exocytosis.
Title: Munc18c phosphorylation by the insulin receptor links cell signaling directly to SNARE exocytosis.
Munc18c(L) gene is closely related to syntaxin-binding protein, Munc18c.It comprises 2 exons separated by a 600bp intron with non-consensus donor & acceptor sites.Exons 1 & 2 of Munc18c(L) overlap with exons 1 through half of 9 of Munc18c gene.
Title: Cloning and characterization of Munc18c(L), a novel murine Munc18c gene paralog.
We conclude, therefore, that Munc18c is not rate-limiting for cardiac substrate uptake, neither under basal conditions nor when maximally stimulated metabolically.
Title: Munc18c is not rate-limiting for glucose and long-chain fatty acid uptake in the heart.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Stxbp3 gene: The Stxbp3 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 490 organisms have orthologs with human gene Stxbp3
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables syntaxin binding	IDA Inferred from Direct Assay more info	PubMed
enables syntaxin binding	IPI Inferred from Physical Interaction more info	PubMed
enables syntaxin binding	ISO Inferred from Sequence Orthology more info
enables syntaxin-1 binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables syntaxin-1 binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to type II interferon	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular glucose homeostasis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within intracellular glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of calcium ion-dependent exocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of glucose import	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of glucose import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter secretion	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in platelet aggregation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein to membrane docking	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to insulin	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to insulin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle docking involved in exocytosis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in phagocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IPI Inferred from Physical Interaction more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in platelet alpha granule	ISO Inferred from Sequence Orthology more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in specific granule	ISO Inferred from Sequence Orthology more info
located_in tertiary granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: syntaxin-binding protein 3

Names: MUNC-18-3; mammalian homolog of Unc-18c; protein unc-18 homolog 3; protein unc-18 homolog C; syntaxin binding protein 3A; unc-18 homolog 3; unc-18C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.