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Stx4a syntaxin 4A (placental) [ Mus musculus (house mouse) ]

Gene ID: 20909, updated on 16-Oct-2021

Summary

Official Symbol
Stx4aprovided by MGI
Official Full Name
syntaxin 4A (placental)provided by MGI
Primary source
MGI:MGI:893577
See related
Ensembl:ENSMUSG00000030805
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Stx4; Syn4; Syn-4
Expression
Ubiquitous expression in bladder adult (RPKM 14.1), limb E14.5 (RPKM 10.0) and 28 other tissues See more
Orthologs
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Genomic context

See Stx4a in Genome Data Viewer
Location:
7; 7 F3
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (127439832..127450160)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127840643..127850988)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (134985322..134992493)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 Neighboring gene syntaxin 1B Neighboring gene zinc finger protein 668 Neighboring gene zinc finger protein 646 Neighboring gene protease, serine 53

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (6)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables SNAP receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables SNARE binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables SNARE binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
enables spectrin binding ISO
Inferred from Sequence Orthology
more info
 
enables sphingomyelin phosphodiesterase activator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in SNARE complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to interferon-gamma IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in cornified envelope assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in exocytic insertion of neurotransmitter receptor to postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane fusion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neurotransmitter transport IEA
Inferred from Electronic Annotation
more info
 
involved_in organelle fusion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of eosinophil degranulation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of immunoglobulin production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
 
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic vesicle docking ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within synaptic vesicle exocytosis TAS
Traceable Author Statement
more info
PubMed 
involved_in synaptic vesicle fusion to presynaptic active zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vesicle docking IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
involved_in vesicle-mediated transport in synapse ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of SNARE complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of SNARE complex ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in lateral loop IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath adaxonal region IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection membrane ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic active zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
 
located_in somatodendritic compartment ISO
Inferred from Sequence Orthology
more info
 
located_in specific granule ISO
Inferred from Sequence Orthology
more info
 
located_in storage vacuole IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009294.3NP_033320.1  syntaxin-4

    See identical proteins and their annotated locations for NP_033320.1

    Status: VALIDATED

    Source sequence(s)
    AC149222
    Consensus CDS
    CCDS21880.1
    UniProtKB/Swiss-Prot
    P70452
    Related
    ENSMUSP00000033075.8, ENSMUST00000033075.14
    Conserved Domains (3) summary
    cd00179
    Location:39189
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
    pfam05739
    Location:236287
    SNARE; SNARE domain
    cl22856
    Location:199260
    SNARE; SNARE motif

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    127439832..127450160
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242311.2XP_030098171.1  syntaxin-4 isoform X8

    Conserved Domains (3) summary
    cd00179
    Location:1138
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
    pfam05739
    Location:185236
    SNARE; SNARE domain
    cl22856
    Location:148209
    SNARE; SNARE motif
  2. XM_006507539.4XP_006507602.1  syntaxin-4 isoform X1

    Conserved Domains (2) summary
    cd00179
    Location:39189
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
    cd15883
    Location:199260
    SNARE_syntaxin4; SNARE motif of syntaxin 4
  3. XM_006507541.4XP_006507604.1  syntaxin-4 isoform X3

    See identical proteins and their annotated locations for XP_006507604.1

    Conserved Domains (2) summary
    cd00179
    Location:39189
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
    cd15883
    Location:199260
    SNARE_syntaxin4; SNARE motif of syntaxin 4
  4. XM_006507542.5XP_006507605.1  syntaxin-4 isoform X4

    Conserved Domains (2) summary
    cd00179
    Location:39189
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
    cd15883
    Location:199260
    SNARE_syntaxin4; SNARE motif of syntaxin 4
  5. XM_006507543.4XP_006507606.1  syntaxin-4 isoform X7

    Conserved Domains (2) summary
    cd00179
    Location:39189
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
    cl22856
    Location:199245
    SNARE; SNARE motif
  6. XM_006507540.5XP_006507603.1  syntaxin-4 isoform X2

    Conserved Domains (2) summary
    cd00179
    Location:1138
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
    cd15883
    Location:148209
    SNARE_syntaxin4; SNARE motif of syntaxin 4
  7. XM_030242310.2XP_030098170.1  syntaxin-4 isoform X5

    Conserved Domains (2) summary
    cd00179
    Location:1138
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
    cd15883
    Location:148209
    SNARE_syntaxin4; SNARE motif of syntaxin 4
  8. XM_036152858.1XP_036008751.1  syntaxin-4 isoform X6

    Conserved Domains (2) summary
    cd00179
    Location:1138
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
    cd15883
    Location:148209
    SNARE_syntaxin4; SNARE motif of syntaxin 4
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