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Stx1a syntaxin 1A (brain) [ Mus musculus (house mouse) ]

Gene ID: 20907, updated on 12-Aug-2019

Summary

Official Symbol
Stx1aprovided by MGI
Official Full Name
syntaxin 1A (brain)provided by MGI
Primary source
MGI:MGI:109355
See related
Ensembl:ENSMUSG00000007207
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HPC-1
Expression
Biased expression in cortex adult (RPKM 99.5), frontal lobe adult (RPKM 66.0) and 8 other tissues See more
Orthologs

Genomic context

See Stx1a in Genome Data Viewer
Location:
5; 5 G2
Exon count:
11
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (135023482..135051100)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (135499442..135526969)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S29 pseudogene Neighboring gene abhydrolase domain containing 11 Neighboring gene abhydrolase domain containing 11, opposite strand Neighboring gene small Cajal body-specific RNA 20 Neighboring gene BUD23, rRNA methyltransferase and ribosome maturation factor Neighboring gene DnaJ heat shock protein family (Hsp40) member C30

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SNARE binding IDA
Inferred from Direct Assay
more info
PubMed 
SNARE binding ISO
Inferred from Sequence Orthology
more info
PubMed 
calcium channel inhibitor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
chloride channel inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
ion channel binding ISO
Inferred from Sequence Orthology
more info
 
kinase binding ISO
Inferred from Sequence Orthology
more info
 
myosin binding ISO
Inferred from Sequence Orthology
more info
 
myosin head/neck binding ISO
Inferred from Sequence Orthology
more info
 
protein N-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding ISO
Inferred from Sequence Orthology
more info
PubMed 
protein binding, bridging ISO
Inferred from Sequence Orthology
more info
 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
SNARE complex assembly ISO
Inferred from Sequence Orthology
more info
 
calcium ion regulated exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hormone secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
modulation of excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
neurotransmitter transport IEA
Inferred from Electronic Annotation
more info
 
positive regulation of calcium ion-dependent exocytosis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of catecholamine secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of excitatory postsynaptic potential IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of exocytosis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neurotransmitter secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of neurotransmitter secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of norepinephrine secretion ISO
Inferred from Sequence Orthology
more info
 
protein localization to membrane ISO
Inferred from Sequence Orthology
more info
 
protein sumoylation ISO
Inferred from Sequence Orthology
more info
 
regulated exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of exocytosis ISO
Inferred from Sequence Orthology
more info
 
regulation of synaptic vesicle priming IGI
Inferred from Genetic Interaction
more info
PubMed 
response to gravity ISO
Inferred from Sequence Orthology
more info
 
secretion by cell ISO
Inferred from Sequence Orthology
more info
 
synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
 
synaptic vesicle exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
 
synaptic vesicle fusion to presynaptic active zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synaptic vesicle fusion to presynaptic active zone membrane ISO
Inferred from Sequence Orthology
more info
 
vesicle docking IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle docking IMP
Inferred from Mutant Phenotype
more info
PubMed 
vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SNARE complex ISO
Inferred from Sequence Orthology
more info
 
acrosomal vesicle IDA
Inferred from Direct Assay
more info
PubMed 
actomyosin ISO
Inferred from Sequence Orthology
more info
 
axon IDA
Inferred from Direct Assay
more info
PubMed 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
intracellular organelle ISO
Inferred from Sequence Orthology
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection ISO
Inferred from Sequence Orthology
more info
PubMed 
nuclear membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
presynaptic active zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
presynaptic active zone membrane ISO
Inferred from Sequence Orthology
more info
 
presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
secretory granule ISO
Inferred from Sequence Orthology
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 
synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
synaptobrevin 2-SNAP-25-syntaxin-1a complex IDA
Inferred from Direct Assay
more info
PubMed 
synaptobrevin 2-SNAP-25-syntaxin-1a complex ISO
Inferred from Sequence Orthology
more info
PubMed 
synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex ISO
Inferred from Sequence Orthology
more info
PubMed 
synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
syntaxin-1A
Names
neuron-specific antigen HPC-1
syntaxin 1 a

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359179.1NP_001346108.1  syntaxin-1A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC084109
    Conserved Domains (2) summary
    pfam00804
    Location:30202
    Syntaxin
    pfam05739
    Location:203254
    SNARE; SNARE domain
  2. NM_016801.4NP_058081.2  syntaxin-1A isoform 1

    See identical proteins and their annotated locations for NP_058081.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC047133, BY240737
    Consensus CDS
    CCDS19731.1
    UniProtKB/Swiss-Prot
    O35526
    UniProtKB/TrEMBL
    Q497P1, Q5D0A4
    Related
    ENSMUSP00000005509.4, ENSMUST00000005509.10
    Conserved Domains (3) summary
    cd00179
    Location:30181
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
    cd15880
    Location:191259
    SNARE_syntaxin1; SNARE motif of syntaxin 1
    pfam00804
    Location:30227
    Syntaxin; Syntaxin

RNA

  1. NR_133683.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC084109
    Related
    ENSMUST00000150838.1
  2. NR_152855.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses two alternate splice junctions in the 3' end compared to variant 1.
    Source sequence(s)
    AC084109

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p6 C57BL/6J

    Range
    135023482..135051100
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504400.4XP_006504463.1  syntaxin-1A isoform X1

    Conserved Domains (3) summary
    cd00179
    Location:30181
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
    cd15848
    Location:191227
    SNARE_syntaxin1-like; SNARE motif of syntaxin 1 and related proteins
    pfam00804
    Location:30227
    Syntaxin; Syntaxin
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