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Ulk4 unc-51-like kinase 4 [ Mus musculus (house mouse) ]

Gene ID: 209012, updated on 21-Mar-2023

Summary

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Official Symbol
Ulk4provided by MGI
Official Full Name
unc-51-like kinase 4provided by MGI
Primary source
MGI:MGI:1921622
See related
Ensembl:ENSMUSG00000040936 AllianceGenome:MGI:1921622
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A730098P15; 4932415A06Rik
Summary
Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Acts upstream of or within several processes, including cerebrospinal fluid circulation; cilium organization; and nervous system development. Is expressed in brain. Used to study hydrocephalus. Orthologous to human ULK4 (unc-51 like kinase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 56.7) and ovary adult (RPKM 3.4) See more
Orthologs
human all
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Genomic context

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See Ulk4 in Genome Data Viewer
Location:
9; 9 F4
Exon count:
41
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (120793520..121115225, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (120964454..121286159, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930593C16 gene Neighboring gene predicted gene, 38502 Neighboring gene catenin (cadherin associated protein), beta 1 Neighboring gene microRNA 7090 Neighboring gene predicted gene, 34945 Neighboring gene zinc finger protein 606 pseudogene Neighboring gene predicted gene, 34735 Neighboring gene VISTA enhancer mm1661 Neighboring gene predicted gene, 34655 Neighboring gene trafficking protein, kinesin binding 1 Neighboring gene predicted gene, 51661

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deletion of Schizophrenia Susceptibility Gene Ulk4 Leads to Abnormal Cognitive Behaviors via Akt-GSK-3 Signaling Pathway in Mice. Hu L, et al. Schizophr Bull, 2022 Jun 21. PMID 35522199,
  2. Ulk4 regulates GABAergic signaling and anxiety-related behavior. Liu M, et al. Transl Psychiatry, 2018 Feb 2. PMID 29391390, Free PMC Article
  3. Ulk4 Is Essential for Ciliogenesis and CSF Flow. Liu M, et al. J Neurosci, 2016 Jul 20. PMID 27445138, Free PMC Article
  4. Ulk4 deficiency leads to hypomyelination in mice. Liu M, et al. Glia, 2018 Jan. PMID 29034508
  5. Identification of disease-relevant modulators of the SHH pathway in the developing brain. Mecklenburg N, et al. Development, 2021 Sep 1. PMID 34463328

See all (23) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deletion of Schizophrenia Susceptibility Gene Ulk4 Leads to Abnormal Cognitive Behaviors via Akt-GSK-3 Signaling Pathway in Mice.
    Title: Deletion of Schizophrenia Susceptibility Gene Ulk4 Leads to Abnormal Cognitive Behaviors via Akt-GSK-3 Signaling Pathway in Mice.
  2. Ulk4 +/tm1a mice exhibit anxiety-related phenotype.
    Title: Ulk4 regulates GABAergic signaling and anxiety-related behavior.
  3. This is the first evidence demonstrating that ULK4 is a crucial regulator of myelination, and ULK4 may therefore become a novel therapeutic target for hypomyelination diseases.
    Title: Ulk4 deficiency leads to hypomyelination in mice.
  4. Targeted disruption of the Ulk4 perturbed mid-neurogenesis and significantly reduced cerebral cortex in postnatal mice.
    Title: Ulk4 Regulates Neural Stem Cell Pool.
  5. This study showed that Ulk4 Is essential for Ciliogenesis and CSF Flow in mice
    Title: Ulk4 Is Essential for Ciliogenesis and CSF Flow.
  6. Congenital hydrocephalus with suppurative rhinosinusitis and otitis media in Ulk4 null mice indicative of primary ciliary dyskinesis
    Title: Congenital hydrocephalus in genetically engineered mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within GABAergic neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within adult behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within axoneme assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within brain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within central nervous system myelination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cerebrospinal fluid circulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within ciliary basal body organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within corpus callosum development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within epithelial cilium movement involved in extracellular fluid movement IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neurogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neuroinflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neuronal stem cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of neuron migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of protein kinase C signaling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within social behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within ventricular system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase ULK4
NP_808257.2
XP_006512086.1
XP_006512087.1
XP_006512088.1
XP_006512089.1
XP_011241254.1
XP_017168752.1
XP_030100042.1
XP_030100043.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177589.3 → NP_808257.2  serine/threonine-protein kinase ULK4

    Status: VALIDATED

    Source sequence(s)
    AK132731, AW456669, BC065094, BM938704
    Consensus CDS
    CCDS52967.1
    UniProtKB/Swiss-Prot
    Q3V129
    UniProtKB/TrEMBL
    E9Q2P5
    Related
    ENSMUSP00000131342.2, ENSMUST00000171923.8
    Conserved Domains (1) summary
    cd14010
    Location:3 → 280
    STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    120793520..121115225 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512024.4 → XP_006512087.1  serine/threonine-protein kinase ULK4 isoform X1

    See identical proteins and their annotated locations for XP_006512087.1

    Conserved Domains (1) summary
    cd14010
    Location:3 → 280
    STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4

  2. XM_030244183.2 → XP_030100043.1  serine/threonine-protein kinase ULK4 isoform X2

    UniProtKB/TrEMBL
    E9Q2P5
    Conserved Domains (1) summary
    cd14010
    Location:3 → 280
    STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4

  3. XM_030244182.1 → XP_030100042.1  serine/threonine-protein kinase ULK4 isoform X2

    UniProtKB/TrEMBL
    E9Q2P5
    Conserved Domains (1) summary
    cd14010
    Location:3 → 280
    STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4

  4. XM_006512023.3 → XP_006512086.1  serine/threonine-protein kinase ULK4 isoform X1

    See identical proteins and their annotated locations for XP_006512086.1

    Conserved Domains (1) summary
    cd14010
    Location:3 → 280
    STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4

  5. XM_017313263.3 → XP_017168752.1  serine/threonine-protein kinase ULK4 isoform X1

    Conserved Domains (1) summary
    cd14010
    Location:3 → 280
    STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4

  6. XM_006512025.5 → XP_006512088.1  serine/threonine-protein kinase ULK4 isoform X3

    Conserved Domains (1) summary
    cd14010
    Location:3 → 280
    STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4

  7. XM_006512026.4 → XP_006512089.1  serine/threonine-protein kinase ULK4 isoform X5

  8. XM_011242952.4 → XP_011241254.1  serine/threonine-protein kinase ULK4 isoform X4

    Related
    ENSMUSP00000129214.2, ENSMUST00000171061.8
    Conserved Domains (1) summary
    cd14010
    Location:3 → 280
    STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3V129.2 GenPept UniProtKB/Swiss-Prot:Q3V129

Gene LinkOut

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