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Sirt7 sirtuin 7 [ Mus musculus (house mouse) ]

Gene ID: 209011, updated on 5-Jul-2025
Official Symbol
Sirt7provided by MGI
Official Full Name
sirtuin 7provided by MGI
Primary source
MGI:MGI:2385849
See related
Ensembl:ENSMUSG00000025138 AllianceGenome:MGI:2385849
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables NAD-dependent protein-lysine depropionylase activity and histone H3K18 deacetylase activity, NAD-dependent. Involved in several processes, including chromatin remodeling; homologous chromosome pairing at meiosis; and protein deacylation. Located in chromatin and site of double-strand break. Is expressed in several structures, including 1st branchial arch maxillary component; central nervous system; eye; gonad; and pancreas. Orthologous to human SIRT7 (sirtuin 7). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in spleen adult (RPKM 45.7), thymus adult (RPKM 44.0) and 28 other tissues See more
Orthologs
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See Sirt7 in Genome Data Viewer
Location:
11 E2; 11 84.34 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120509197..120515840, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120618371..120625014, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene neuropeptide B Neighboring gene phosphate cytidylyltransferase 2, ethanolamine Neighboring gene STARR-positive B cell enhancer ABC_E7114 Neighboring gene microRNA 6936 Neighboring gene STARR-positive B cell enhancer ABC_E7115 Neighboring gene v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian) Neighboring gene predicted gene, 17586 Neighboring gene pyrroline-5-carboxylate reductase 1 Neighboring gene STARR-positive B cell enhancer mm9_chr11:120504984-120505285

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • MGC31235, MGC37560

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD+ binding IEA
Inferred from Electronic Annotation
more info
 
enables NAD-dependent protein lysine deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables NAD-dependent protein lysine deacetylase activity IEA
Inferred from Electronic Annotation
more info
 
enables NAD-dependent protein lysine deacetylase activity ISO
Inferred from Sequence Orthology
more info
 
enables NAD-dependent protein-lysine depropionylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables NAD-dependent protein-lysine depropionylase activity IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables histone H3K18 deacetylase activity, NAD-dependent IBA
Inferred from Biological aspect of Ancestor
more info
 
enables histone H3K18 deacetylase activity, NAD-dependent IEA
Inferred from Electronic Annotation
more info
 
enables histone H3K18 deacetylase activity, NAD-dependent IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables histone H3K18 deacetylase activity, NAD-dependent ISO
Inferred from Sequence Orthology
more info
 
enables histone H3K18 deacetylase activity, NAD-dependent ISS
Inferred from Sequence or Structural Similarity
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-glutaryllysine deglutarylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein-glutaryllysine deglutarylase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein-glutaryllysine deglutarylase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-glutaryllysine deglutarylase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein-succinyllysine desuccinylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein-succinyllysine desuccinylase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein-succinyllysine desuccinylase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-succinyllysine desuccinylase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair-dependent chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA repair-dependent chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair-dependent chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in DNA repair-dependent chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA repair-dependent chromatin remodeling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in R-loop processing IEA
Inferred from Electronic Annotation
more info
 
involved_in R-loop processing ISO
Inferred from Sequence Orthology
more info
 
involved_in R-loop processing ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in homologous chromosome pairing at meiosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression, epigenetic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of gluconeogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gluconeogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of rRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of rRNA processing ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of rRNA processing ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transcription by RNA polymerase I IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase I ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase I ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein deacetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein deglutarylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein deglutarylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein depropionylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in rRNA transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in rRNA transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in rRNA transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitochondrion organization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mitochondrion organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein export from nucleus IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of protein export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of transcription of nucleolar large rRNA by RNA polymerase I IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription of nucleolar large rRNA by RNA polymerase I ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription of nucleolar large rRNA by RNA polymerase I ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in transcription initiation-coupled chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in transcription initiation-coupled chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in transposable element silencing IEA
Inferred from Electronic Annotation
more info
 
involved_in transposable element silencing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromatin IEA
Inferred from Electronic Annotation
more info
 
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleolus organizer region IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus organizer region ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus organizer region ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in site of double-strand break IEA
Inferred from Electronic Annotation
more info
 
located_in site of double-strand break IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
NAD-dependent protein deacetylase sirtuin-7
Names
NAD-dependent deacetylase sirtuin-7
NAD-dependent protein deacylase sirtuin-7
SIR2-like protein 7
regulatory protein SIR2 homolog 7
NP_001350368.1
NP_694696.2

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363439.1NP_001350368.1  NAD-dependent protein deacetylase sirtuin-7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL663030
    Conserved Domains (2) summary
    cd01410
    Location:102315
    SIRT7; SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent ...
    cl25732
    Location:8101
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_153056.3NP_694696.2  NAD-dependent protein deacetylase sirtuin-7 isoform 1

    See identical proteins and their annotated locations for NP_694696.2

    Status: VALIDATED

    Source sequence(s)
    AK135484, AL663030, AV001692, AY251540, BY125424
    Consensus CDS
    CCDS49006.1
    UniProtKB/Swiss-Prot
    A2ABY7, Q6X7B7, Q8BKJ9, Q8QZZ5
    Related
    ENSMUSP00000079093.6, ENSMUST00000080202.12
    Conserved Domains (1) summary
    cd01410
    Location:102315
    SIRT7; SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    120509197..120515840 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001779937.3 RNA Sequence

    Related
    ENSMUST00000134255.8
  2. XR_003949369.2 RNA Sequence