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Sirt7 sirtuin 7 [ Mus musculus (house mouse) ]

Gene ID: 209011, updated on 25-Sep-2020

Summary

Official Symbol
Sirt7provided by MGI
Official Full Name
sirtuin 7provided by MGI
Primary source
MGI:MGI:2385849
See related
Ensembl:ENSMUSG00000025138
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Expression
Ubiquitous expression in spleen adult (RPKM 45.7), thymus adult (RPKM 44.0) and 28 other tissues See more
Orthologs

Genomic context

See Sirt7 in Genome Data Viewer
Location:
11; 11 E2
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120509197..120515840, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120618371..120625014, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (120479686..120486316, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene neuropeptide B Neighboring gene phosphate cytidylyltransferase 2, ethanolamine Neighboring gene microRNA 6936 Neighboring gene v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian) Neighboring gene predicted gene, 17586 Neighboring gene pyrroline-5-carboxylate reductase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC31235, MGC37560

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NAD+ binding IEA
Inferred from Electronic Annotation
more info
 
NAD-dependent histone deacetylase activity (H3-K18 specific) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NAD-dependent histone deacetylase activity (H3-K18 specific) IMP
Inferred from Mutant Phenotype
more info
PubMed 
NAD-dependent histone deacetylase activity (H3-K18 specific) ISO
Inferred from Sequence Orthology
more info
 
NAD-dependent protein deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
NAD-dependent protein deacetylase activity ISO
Inferred from Sequence Orthology
more info
 
chromatin binding ISO
Inferred from Sequence Orthology
more info
 
deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-glutaryllysine deglutarylase activity ISO
Inferred from Sequence Orthology
more info
 
protein-succinyllysine desuccinylase activity ISO
Inferred from Sequence Orthology
more info
 
transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA repair IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
chromatin organization IEA
Inferred from Electronic Annotation
more info
 
histone H3 deacetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone H3 deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone H3 deacetylation ISO
Inferred from Sequence Orthology
more info
 
histone glutamine methylation ISO
Inferred from Sequence Orthology
more info
 
histone modification ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transposition IMP
Inferred from Mutant Phenotype
more info
PubMed 
osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-lysine desuccinylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of rRNA processing ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription involved in exit from mitosis ISO
Inferred from Sequence Orthology
more info
 
protein deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
protein deacetylation ISO
Inferred from Sequence Orthology
more info
 
protein deglutarylation ISO
Inferred from Sequence Orthology
more info
 
rRNA transcription ISO
Inferred from Sequence Orthology
more info
 
regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
 
regulation of double-strand break repair via nonhomologous end joining IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of gluconeogenesis ISO
Inferred from Sequence Orthology
more info
 
regulation of mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitochondrion organization ISO
Inferred from Sequence Orthology
more info
 
regulation of protein export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription of nucleolar large rRNA by RNA polymerase I ISO
Inferred from Sequence Orthology
more info
 
synapsis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
chromatin IDA
Inferred from Direct Assay
more info
PubMed 
chromatin ISO
Inferred from Sequence Orthology
more info
 
chromosome IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleolus organizer region ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
site of double-strand break IMP
Inferred from Mutant Phenotype
more info
PubMed 
site of double-strand break ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
NAD-dependent protein deacetylase sirtuin-7
Names
NAD-dependent deacetylase sirtuin-7
NAD-dependent protein deacylase sirtuin-7
SIR2-like protein 7
regulatory protein SIR2 homolog 7
NP_001350368.1
NP_694696.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363439.1NP_001350368.1  NAD-dependent protein deacetylase sirtuin-7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL663030
    Conserved Domains (2) summary
    cd01410
    Location:102315
    SIRT7; SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent ...
    cl25732
    Location:8101
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_153056.3NP_694696.2  NAD-dependent protein deacetylase sirtuin-7 isoform 1

    See identical proteins and their annotated locations for NP_694696.2

    Status: VALIDATED

    Source sequence(s)
    AK135484, AL663030, AV001692, AY251540, BY125424
    Consensus CDS
    CCDS49006.1
    UniProtKB/Swiss-Prot
    Q8BKJ9
    Related
    ENSMUSP00000079093.5, ENSMUST00000080202.11
    Conserved Domains (1) summary
    cd01410
    Location:102315
    SIRT7; SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    120509197..120515840 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001779937.3 RNA Sequence

  2. XR_003949369.2 RNA Sequence

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