Sirt7 sirtuin 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sirt7provided by MGI
Official Full Name: sirtuin 7provided by MGI
Primary source: MGI:MGI:2385849
See related: Ensembl:ENSMUSG00000025138 Vega:OTTMUSG00000004085
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Expression: Ubiquitous expression in spleen adult (RPKM 45.7), thymus adult (RPKM 44.0) and 28 other tissues See more
Orthologs: human all

Genomic context

Location:: 11; 11 E2

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	GRCm38.p4 (GCF_000001635.24)	11	NC_000077.6 (120618372..120625008, complement)
Build 37.2	previous assembly	MGSCv37 (GCF_000001635.18)	11	NC_000077.5 (120479686..120486316, complement)

Chromosome 11 - NC_000077.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

the results of our study suggest that SIRT7 is involved in protecting neurons against OGD/R-induced injury, possibly through regulation of the p53-mediated proapoptotic signaling pathway, indicating a potential therapeutic target for cerebral ischemia/reperfusion injury.
Title: Sirtuin7 is involved in protecting neurons against oxygen-glucose deprivation and reoxygenation-induced injury through regulation of the p53 signaling pathway.
Histological analysis revealed that there is no apparent structural abnormality of the amygdala and hippocampus, which are regions involved in fear memory consolidation, in Sirt7 KO mice. Our results indicate that SIRT7 is involved in the consolidation of fear memory.
Title: Sirtuin 7 is involved in the consolidation of fear memory in mice.
Data suggest that high-fat diet (HFD) alters regulation of expression of sirtuins (Sirt4 and Sirt7) and enzymes in NAD biosynthetic pathway (Tdo2 and Nnmt); these alterations are more prominent in liver as compared to white adipose tissue or skeletal muscle; Tdo2 and Nnmt may serve as markers of HFD consumption. (Tdo2 = tryptophan 2,3-dioxygenase; Nnmt = nicotinamide N-methyltransferase)
Title: Tissue-specific regulation of sirtuin and nicotinamide adenine dinucleotide biosynthetic pathways identified in C57Bl/6 mice in response to high-fat feeding.
The Sirt7 mediates heterochromatin formation at rRNA genes through recruitment of DNA methyltransferase 1 and another member of the sirtuin family, Sirt1.
Title: Sirt7 stabilizes rDNA heterochromatin through recruitment of DNMT1 and Sirt1.
the decline in SIRT7 in lung fibroblasts has a profibrotic effect, which is mediated by changes in Smad3 levels.
Title: Sirtuin 7 is decreased in pulmonary fibrosis and regulates the fibrotic phenotype of lung fibroblasts.
SIRT7 inhibits TR4 degradation by deacetylation of DDB1.
Title: Sirtuin 7-dependent deacetylation of DDB1 regulates the expression of nuclear receptor TR4.
These results reveal a direct role for SIRT7 in double-strand break repair and establish a functional link between SIRT7-mediated histone H3 K18 deacetylation and the maintenance of genome integrity.
Title: SIRT7 promotes genome integrity and modulates non-homologous end joining DNA repair.
miR-93 inhibits the metabolic target Sirt7, which we identified as a major driver of in vivo adipogenesis via induction of differentiation and maturation of early adipocyte precursors.
Title: MiR-93 Controls Adiposity via Inhibition of Sirt7 and Tbx3.
The role of SIRT7 has emerged in protein synthesis, chromatin remodelling, cellular survival and lipid metabolism.
Title: Sirtuin 7 in cell proliferation, stress and disease: Rise of the Seventh Sirtuin!
SIRT7 stabilizes and activates the GABP alpha/GABPbeta complex via deacetylation of GABPbeta1.
Title: A SIRT7-dependent acetylation switch of GABPβ1 controls mitochondrial function.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Sirt7 (e-PCR), detects polymorphism
- UniSTS:531301

Sirt7 (e-PCR), detects polymorphism
- UniSTS:531302

Homology

Homologs of the Sirt7 gene: The Sirt7 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, and frog.
Orthologs from Annotation Pipeline: 227 organisms have orthologs with human gene Sirt7
The Hierarchical Catalog of Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
NAD+ binding	IEA Inferred from Electronic Annotation more info
NAD-dependent histone deacetylase activity (H3-K18 specific)	ISO Inferred from Sequence Orthology more info
chromatin binding	ISO Inferred from Sequence Orthology more info
hydrolase activity	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
chromatin organization	IEA Inferred from Electronic Annotation more info
histone H3 deacetylation	ISO Inferred from Sequence Orthology more info
histone H4 deacetylation	ISO Inferred from Sequence Orthology more info
negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
positive regulation of transcription involved in exit from mitosis	ISO Inferred from Sequence Orthology more info
rRNA transcription	ISO Inferred from Sequence Orthology more info
regulation of transcription, DNA-templated	IEA Inferred from Electronic Annotation more info
transcription, DNA-templated	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
nucleolus	ISO Inferred from Sequence Orthology more info
nucleolus organizer region	ISO Inferred from Sequence Orthology more info
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: NAD-dependent protein deacetylase sirtuin-7

Names: NAD-dependent deacetylase sirtuin-7; SIR2-like protein 7; regulatory protein SIR2 homolog 7

NP_694696.2

EC 3.5.1.-

XP_017169897.1

EC 3.5.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001363439.1 → NP_001350368.1 NAD-dependent protein deacetylase sirtuin-7 isoform 2

Status: VALIDATED

Source sequence(s)

AL663030
NM_153056.3 → NP_694696.2 NAD-dependent protein deacetylase sirtuin-7 isoform 1

See identical proteins and their annotated locations for NP_694696.2

Status: VALIDATED

Source sequence(s)

AK135484, AL663030, AV001692, AY251540, BY125424

Consensus CDS

CCDS49006.1

UniProtKB/Swiss-Prot

Q8BKJ9

Related

ENSMUSP00000079093.5, OTTMUSP00000004468, ENSMUST00000080202.11

Conserved Domains (1) summary

cd01410
Location:102 → 315

SIRT7; SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent ...