Sirt7 sirtuin 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sirt7provided by MGI
Official Full Name: sirtuin 7provided by MGI
Primary source: MGI:MGI:2385849
See related: Ensembl:ENSMUSG00000025138 AllianceGenome:MGI:2385849
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables NAD-dependent histone deacetylase activity (H3-K18 specific) and protein-propionyllysine depropionylase activity. Involved in several processes, including homologous chromosome pairing at meiosis; protein deacylation; and regulation of double-strand break repair via nonhomologous end joining. Located in chromatin and site of double-strand break. Is expressed in several structures, including 1st branchial arch maxillary component; central nervous system; eye; gonad; and spleen. Orthologous to human SIRT7 (sirtuin 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in spleen adult (RPKM 45.7), thymus adult (RPKM 44.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11; 11 E2

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (120509197..120515840, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (120618371..120625014, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Oncogenic SIRT7 inhibits GATA4 transcriptional activity and activates the Wnt signaling pathway in ovarian cancer.
Title: Oncogenic SIRT7 inhibits GATA4 transcriptional activity and activates the Wnt signaling pathway in ovarian cancer.
SIRT7 affects autophagy and activation of hepatic stellate cells by regulating the acetylation level of high mobility group protein 1.
Title: SIRT7 affects autophagy and activation of hepatic stellate cells by regulating the acetylation level of high mobility group protein 1.
SIRT7 suppresses energy expenditure and thermogenesis by regulating brown adipose tissue functions in mice.
Title: SIRT7 suppresses energy expenditure and thermogenesis by regulating brown adipose tissue functions in mice.
NMN ameliorated radiation induced damage in NRF2-deficient cell and mice via regulating SIRT6 and SIRT7.
Title: NMN ameliorated radiation induced damage in NRF2-deficient cell and mice via regulating SIRT6 and SIRT7.
Sirtuin 7 mitigates renal ferroptosis, fibrosis and injury in hypertensive mice by facilitating the KLF15/Nrf2 signaling.
Title: Sirtuin 7 mitigates renal ferroptosis, fibrosis and injury in hypertensive mice by facilitating the KLF15/Nrf2 signaling.
SIRT7 Deficiency Protects against Aging-Associated Glucose Intolerance and Extends Lifespan in Male Mice.
Title: SIRT7 Deficiency Protects against Aging-Associated Glucose Intolerance and Extends Lifespan in Male Mice.
Aging-Conferred SIRT7 Decline Inhibits Rosacea-Like Skin Inflammation by Modulating Toll-Like Receptor 2NF-kappaB Signaling.
Title: Aging-Conferred SIRT7 Decline Inhibits Rosacea-Like Skin Inflammation by Modulating Toll-Like Receptor 2‒NF-κB Signaling.
MicroRNA-762 Modulates Lipopolysaccharide-induced Acute Lung Injury via SIRT7.
Title: MicroRNA-762 Modulates Lipopolysaccharide-induced Acute Lung Injury via SIRT7.
Sirt7 Deficiency Attenuates Neointimal Formation Following Vascular Injury by Modulating Vascular Smooth Muscle Cell Proliferation.
Title: Sirt7 Deficiency Attenuates Neointimal Formation Following Vascular Injury by Modulating Vascular Smooth Muscle Cell Proliferation.
Sirtuin 7 Deficiency Reduces Inflammation and Tubular Damage Induced by an Episode of Acute Kidney Injury.
Title: Sirtuin 7 Deficiency Reduces Inflammation and Tubular Damage Induced by an Episode of Acute Kidney Injury.

Submit: New GeneRIF Correction See all GeneRIFs (43)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Sirt7 (e-PCR), detects polymorphism
- UniSTS:531301

Sirt7 (e-PCR), detects polymorphism
- UniSTS:531302

Homology

Homologs of the Sirt7 gene: The Sirt7 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, and frog.
Orthologs from Annotation Pipeline: 487 organisms have orthologs with human gene Sirt7
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NAD+ binding	IEA Inferred from Electronic Annotation more info
enables NAD-dependent histone H3K18 deacetylase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables NAD-dependent histone H3K18 deacetylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables NAD-dependent histone H3K18 deacetylase activity	ISO Inferred from Sequence Orthology more info
enables NAD-dependent protein deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
enables NAD-dependent protein deacetylase activity	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein lysine deacetylase activity	IEA Inferred from Electronic Annotation more info
enables protein methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-glutaryllysine deglutarylase activity	ISO Inferred from Sequence Orthology more info
enables protein-propionyllysine depropionylase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-succinyllysine desuccinylase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA repair-dependent chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA repair-dependent chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in R-loop processing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in histone H3 deacetylation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in homologous chromosome pairing at meiosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression, epigenetic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transposition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gluconeogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of rRNA processing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase I	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription involved in exit from mitosis	ISO Inferred from Sequence Orthology more info
involved_in protein deacetylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein deacetylation	ISO Inferred from Sequence Orthology more info
involved_in protein deglutarylation	ISO Inferred from Sequence Orthology more info
involved_in protein depropionylation	IDA Inferred from Direct Assay more info	PubMed
involved_in rRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA repair	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription of nucleolar large rRNA by RNA polymerase I	ISO Inferred from Sequence Orthology more info
involved_in transcription initiation-coupled chromatin remodeling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleolus organizer region	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in site of double-strand break	IMP Inferred from Mutant Phenotype more info	PubMed
located_in site of double-strand break	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NAD-dependent protein deacetylase sirtuin-7

Names: NAD-dependent deacetylase sirtuin-7; NAD-dependent protein deacylase sirtuin-7; SIR2-like protein 7; regulatory protein SIR2 homolog 7

NP_001350368.1

EC 2.3.1.286

NP_694696.2

EC 2.3.1.286

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001363439.1 → NP_001350368.1 NAD-dependent protein deacetylase sirtuin-7 isoform 2

Status: VALIDATED

Source sequence(s)

AL663030

Conserved Domains (2) summary

cd01410
Location:102 → 315

SIRT7; SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent ...

cl25732
Location:8 → 101

SMC_N; RecF/RecN/SMC N terminal domain
NM_153056.3 → NP_694696.2 NAD-dependent protein deacetylase sirtuin-7 isoform 1

See identical proteins and their annotated locations for NP_694696.2

Status: VALIDATED

Source sequence(s)

AK135484, AL663030, AV001692, AY251540, BY125424

Consensus CDS

CCDS49006.1

UniProtKB/Swiss-Prot

Q8BKJ9, Q8QZZ5

UniProtKB/TrEMBL

A0A8C6G4N5

Related

ENSMUSP00000079093.6, ENSMUST00000080202.12

Conserved Domains (1) summary

cd01410
Location:102 → 315

SIRT7; SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent ...