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Sirt7 sirtuin 7 [ Mus musculus (house mouse) ]

Gene ID: 209011, updated on 3-Jun-2018
Official Symbol
Sirt7provided by MGI
Official Full Name
sirtuin 7provided by MGI
Primary source
MGI:MGI:2385849
See related
Ensembl:ENSMUSG00000025138 Vega:OTTMUSG00000004085
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Expression
Ubiquitous expression in spleen adult (RPKM 45.7), thymus adult (RPKM 44.0) and 28 other tissues See more
Orthologs
See Sirt7 in Genome Data Viewer
Location:
11; 11 E2
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (120618372..120625008, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (120479686..120486316, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene anaphase promoting complex subunit 11 Neighboring gene neuropeptide B Neighboring gene phosphate cytidylyltransferase 2, ethanolamine Neighboring gene microRNA 6936 Neighboring gene v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian) Neighboring gene pyrroline-5-carboxylate reductase 1

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC31235, MGC37560

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NAD+ binding IEA
Inferred from Electronic Annotation
more info
 
NAD-dependent histone deacetylase activity (H3-K18 specific) ISO
Inferred from Sequence Orthology
more info
 
chromatin binding ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
chromatin organization IEA
Inferred from Electronic Annotation
more info
 
histone H3 deacetylation ISO
Inferred from Sequence Orthology
more info
 
histone H4 deacetylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription involved in exit from mitosis ISO
Inferred from Sequence Orthology
more info
 
rRNA transcription ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleolus organizer region ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
NAD-dependent protein deacetylase sirtuin-7
Names
NAD-dependent deacetylase sirtuin-7
SIR2-like protein 7
regulatory protein SIR2 homolog 7
NP_694696.2
XP_017169897.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363439.1NP_001350368.1  NAD-dependent protein deacetylase sirtuin-7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL663030
  2. NM_153056.3NP_694696.2  NAD-dependent protein deacetylase sirtuin-7 isoform 1

    See identical proteins and their annotated locations for NP_694696.2

    Status: VALIDATED

    Source sequence(s)
    AK135484, AL663030, AV001692, AY251540, BY125424
    Consensus CDS
    CCDS49006.1
    UniProtKB/Swiss-Prot
    Q8BKJ9
    Related
    ENSMUSP00000079093.5, OTTMUSP00000004468, ENSMUST00000080202.11
    Conserved Domains (1) summary
    cd01410
    Location:102315
    SIRT7; SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

    Range
    120618372..120625008 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314408.1XP_017169897.1  NAD-dependent protein deacetylase sirtuin-7 isoform X1

RNA

  1. XR_001779937.1 RNA Sequence

    Related
    ENSMUST00000134255.7
  2. XR_001779938.1 RNA Sequence

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