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Sirt7 sirtuin 7 [ Mus musculus (house mouse) ]

Gene ID: 209011, updated on 24-Jan-2023

Summary

Official Symbol
Sirt7provided by MGI
Official Full Name
sirtuin 7provided by MGI
Primary source
MGI:MGI:2385849
See related
Ensembl:ENSMUSG00000025138 AllianceGenome:MGI:2385849
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables NAD-dependent histone deacetylase activity (H3-K18 specific) and protein-propionyllysine depropionylase activity. Involved in several processes, including homologous chromosome pairing at meiosis; protein deacylation; and regulation of double-strand break repair via nonhomologous end joining. Located in chromatin and site of double-strand break. Is expressed in several structures, including 1st branchial arch maxillary component; central nervous system; eye; gonad; and spleen. Orthologous to human SIRT7 (sirtuin 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 45.7), thymus adult (RPKM 44.0) and 28 other tissues See more
Orthologs
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Genomic context

See Sirt7 in Genome Data Viewer
Location:
11; 11 E2
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120509197..120515840, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120618371..120625014, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene neuropeptide B Neighboring gene phosphate cytidylyltransferase 2, ethanolamine Neighboring gene microRNA 6936 Neighboring gene v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian) Neighboring gene predicted gene, 17586 Neighboring gene pyrroline-5-carboxylate reductase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC31235, MGC37560

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD+ binding IEA
Inferred from Electronic Annotation
more info
 
enables NAD-dependent histone H3K18 deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables NAD-dependent histone H3K18 deacetylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables NAD-dependent histone H3K18 deacetylase activity ISO
Inferred from Sequence Orthology
more info
 
enables NAD-dependent protein deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables NAD-dependent protein deacetylase activity ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein lysine deacetylase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein-glutaryllysine deglutarylase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-propionyllysine depropionylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-succinyllysine desuccinylase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair-dependent chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in R-loop processing ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in histone H3 deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in histone H3 deacetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in homologous chromosome pairing at meiosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transposition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of rRNA processing ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase I ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription involved in exit from mitosis ISO
Inferred from Sequence Orthology
more info
 
involved_in protein deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein deacetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein deglutarylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein depropionylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in rRNA transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of double-strand break repair via nonhomologous end joining IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of gluconeogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mitochondrion organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription of nucleolar large rRNA by RNA polymerase I ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus organizer region ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in site of double-strand break IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
NAD-dependent protein deacetylase sirtuin-7
Names
NAD-dependent deacetylase sirtuin-7
NAD-dependent protein deacylase sirtuin-7
SIR2-like protein 7
regulatory protein SIR2 homolog 7
NP_001350368.1
NP_694696.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363439.1NP_001350368.1  NAD-dependent protein deacetylase sirtuin-7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL663030
    Conserved Domains (2) summary
    cd01410
    Location:102315
    SIRT7; SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent ...
    cl25732
    Location:8101
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_153056.3NP_694696.2  NAD-dependent protein deacetylase sirtuin-7 isoform 1

    See identical proteins and their annotated locations for NP_694696.2

    Status: VALIDATED

    Source sequence(s)
    AK135484, AL663030, AV001692, AY251540, BY125424
    Consensus CDS
    CCDS49006.1
    UniProtKB/Swiss-Prot
    Q8BKJ9, Q8QZZ5
    UniProtKB/TrEMBL
    A0A8C6G4N5
    Related
    ENSMUSP00000079093.6, ENSMUST00000080202.12
    Conserved Domains (1) summary
    cd01410
    Location:102315
    SIRT7; SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    120509197..120515840 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001779937.3 RNA Sequence

    Related
    ENSMUST00000134255.8
  2. XR_003949369.2 RNA Sequence