Sirt7 sirtuin 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sirt7provided by MGI
Official Full Name: sirtuin 7provided by MGI
Primary source: MGI:MGI:2385849
See related: Ensembl:ENSMUSG00000025138
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Expression: Ubiquitous expression in spleen adult (RPKM 45.7), thymus adult (RPKM 44.0) and 28 other tissues See more
Orthologs: human all

Genomic context

Location:: 11; 11 E2

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (120509197..120515840, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (120618371..120625014, complement)
Build 37.2	previous assembly	MGSCv37 (GCF_000001635.18)	11	NC_000077.5 (120479686..120486316, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sirt7 deficiency in cardiomyocytes promotes cardiomyocyte hypertrophy in response to pressure overload. Sirt7 exerts its antihypertrophic effect by interacting with and promoting deacetylation of GATA4
Title: Cardiomyocyte Sirt (Sirtuin) 7 Ameliorates Stress-Induced Cardiac Hypertrophy by Interacting With and Deacetylating GATA4.
our findings demonstrate a pivotal role for SIRT7 in oocyte meiosis by promoting chromosome synapsis and have unveiled the importance of SIRT7 as novel regulator of the reproductive lifespan.
Title: SIRT7 promotes chromosome synapsis during prophase I of female meiosis.
SIRT7 mediates L1 elements transcriptional repression and their association with the nuclear lamina.
Title: SIRT7 mediates L1 elements transcriptional repression and their association with the nuclear lamina.
Removal of the acetyl-group at K230 in Sirt1 due to the absence of Sirt7 leads to hyperactivation of Sirt1 and thereby to constantly increased activity of Suv39h1.
Title: Sirt7 inhibits Sirt1-mediated activation of Suv39h1.
Our results indicate that SIRT7 plays an important role in cisplatin-induced AKI and suggest the possibility of SIRT7 as a novel therapeutic target for cisplatin-induced nephrotoxicity.
Title: Sirtuin 7 Deficiency Ameliorates Cisplatin-induced Acute Kidney Injury Through Regulation of the Inflammatory Response.
SIRT7-elicits an autophagic response that plays a protective role against cell death and the SIRT7-inhibition has a potential to improve the efficacy of anti-metabolic therapy in non-small cell lung cancer cells.
Title: Depletion of SIRT7 sensitizes human non-small cell lung cancer cells to gemcitabine therapy by inhibiting autophagy.
The results indicate that miR-148b-3p contributes to the regulation of hypoxia/reoxygenation-induced cardiomyocyte apoptosis in vitro through targeting SIRT7 and modulating p53-mediated pro-apoptotic signaling.
Title: MicroRNA-148b-3p is involved in regulating hypoxia/reoxygenation-induced injury of cardiomyocytes in vitro through modulating SIRT7/p53 signaling.
SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7.
Title: SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix.
Data indicate that Sirt7 has a slight protective impact on both the adaptive immune system and neurogenesis. However, overall this epigenetic factor is not capable of impacting the acute or chronic phase of neuroinflammation.
Title: Role of the epigenetic factor Sirt7 in neuroinflammation and neurogenesis.
Loss of SIRT7 is associated with Impairment of Adipogenesis and increased Sirt1 Activity.
Title: Sirt7 promotes adipogenesis in the mouse by inhibiting autocatalytic activation of Sirt1.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Sirt7 (e-PCR), detects polymorphism
- UniSTS:531301

Sirt7 (e-PCR), detects polymorphism
- UniSTS:531302

Homology

Homologs of the Sirt7 gene: The Sirt7 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, and frog.
Orthologs from Annotation Pipeline: 326 organisms have orthologs with human gene Sirt7
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
NAD+ binding	IEA Inferred from Electronic Annotation more info
NAD-dependent histone deacetylase activity (H3-K18 specific)	IBA Inferred from Biological aspect of Ancestor more info	PubMed
NAD-dependent histone deacetylase activity (H3-K18 specific)	IMP Inferred from Mutant Phenotype more info	PubMed
NAD-dependent histone deacetylase activity (H3-K18 specific)	ISO Inferred from Sequence Orthology more info
NAD-dependent protein deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
NAD-dependent protein deacetylase activity	ISO Inferred from Sequence Orthology more info
chromatin binding	ISO Inferred from Sequence Orthology more info
deacetylase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
histone deacetylase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
metal ion binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein-glutaryllysine deglutarylase activity	ISO Inferred from Sequence Orthology more info
protein-succinyllysine desuccinylase activity	ISO Inferred from Sequence Orthology more info
transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
DNA repair	IEA Inferred from Electronic Annotation more info
cellular response to DNA damage stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
cellular response to DNA damage stimulus	ISO Inferred from Sequence Orthology more info
chromatin organization	IEA Inferred from Electronic Annotation more info
histone H3 deacetylation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
histone H3 deacetylation	IMP Inferred from Mutant Phenotype more info	PubMed
histone H3 deacetylation	ISO Inferred from Sequence Orthology more info
histone glutamine methylation	ISO Inferred from Sequence Orthology more info
histone modification	ISO Inferred from Sequence Orthology more info
negative regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed
negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
negative regulation of transposition	IMP Inferred from Mutant Phenotype more info	PubMed
osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
peptidyl-lysine desuccinylation	ISO Inferred from Sequence Orthology more info
positive regulation of rRNA processing	ISO Inferred from Sequence Orthology more info
positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
positive regulation of transcription involved in exit from mitosis	ISO Inferred from Sequence Orthology more info
protein deacetylation	IDA Inferred from Direct Assay more info	PubMed
protein deacetylation	ISO Inferred from Sequence Orthology more info
protein deglutarylation	ISO Inferred from Sequence Orthology more info
rRNA transcription	ISO Inferred from Sequence Orthology more info
regulation of DNA repair	ISO Inferred from Sequence Orthology more info
regulation of double-strand break repair via nonhomologous end joining	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of gluconeogenesis	ISO Inferred from Sequence Orthology more info
regulation of mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of mitochondrion organization	ISO Inferred from Sequence Orthology more info
regulation of protein export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of transcription of nucleolar large rRNA by RNA polymerase I	ISO Inferred from Sequence Orthology more info
synapsis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
chromatin	IDA Inferred from Direct Assay more info	PubMed
chromatin	ISO Inferred from Sequence Orthology more info
chromosome	IEA Inferred from Electronic Annotation more info
cytoplasm	IEA Inferred from Electronic Annotation more info
nucleolus	ISO Inferred from Sequence Orthology more info
nucleolus organizer region	ISO Inferred from Sequence Orthology more info
nucleoplasm	ISO Inferred from Sequence Orthology more info
nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
nucleus	ISO Inferred from Sequence Orthology more info
site of double-strand break	IMP Inferred from Mutant Phenotype more info	PubMed
site of double-strand break	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NAD-dependent protein deacetylase sirtuin-7

Names: NAD-dependent deacetylase sirtuin-7; NAD-dependent protein deacylase sirtuin-7; SIR2-like protein 7; regulatory protein SIR2 homolog 7

NP_001350368.1

EC 2.3.1.286

NP_694696.2

EC 2.3.1.286

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001363439.1 → NP_001350368.1 NAD-dependent protein deacetylase sirtuin-7 isoform 2

Status: VALIDATED

Source sequence(s)

AL663030

Conserved Domains (2) summary

cd01410
Location:102 → 315

SIRT7; SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent ...

cl25732
Location:8 → 101

SMC_N; RecF/RecN/SMC N terminal domain
NM_153056.3 → NP_694696.2 NAD-dependent protein deacetylase sirtuin-7 isoform 1

See identical proteins and their annotated locations for NP_694696.2

Status: VALIDATED

Source sequence(s)

AK135484, AL663030, AV001692, AY251540, BY125424

Consensus CDS

CCDS49006.1

UniProtKB/Swiss-Prot

Q8BKJ9

Related

ENSMUSP00000079093.5, ENSMUST00000080202.11

Conserved Domains (1) summary

cd01410
Location:102 → 315

SIRT7; SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent ...