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Bhlhe40 basic helix-loop-helix family, member e40 [ Mus musculus (house mouse) ]

Gene ID: 20893, updated on 13-Mar-2020

Summary

Official Symbol
Bhlhe40provided by MGI
Official Full Name
basic helix-loop-helix family, member e40provided by MGI
Primary source
MGI:MGI:1097714
See related
Ensembl:ENSMUSG00000030103
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CR8; Dec1; Bhlhb2; Clast5; Sharp2; Stra13; Stra14; C130042M06Rik
Summary
This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with Arntl or compete for E-box binding sites in the promoter of Per1 and repress Clock/Arntl's transactivation of Per1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. [provided by RefSeq, Feb 2014]
Expression
Ubiquitous expression in adrenal adult (RPKM 15.2), kidney adult (RPKM 15.1) and 27 other tissues See more
Orthologs

Genomic context

See Bhlhe40 in Genome Data Viewer
Location:
6; 6 E2
Exon count:
5
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (108660629..108666925)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (108610623..108616919)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene inositol 1,4,5-trisphosphate receptor 1 Neighboring gene predicted gene, 44040 Neighboring gene RIKEN cDNA 0610040F04 gene Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 pseudogene Neighboring gene predicted gene, 35359 Neighboring gene uncharacterized LOC115486328 Neighboring gene ADP-ribosylation factor-like 8B Neighboring gene predicted gene, 35417

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
E-box binding IDA
Inferred from Direct Assay
more info
PubMed 
E-box binding ISO
Inferred from Sequence Orthology
more info
 
MRF binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II activating transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
bHLH transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
anterior/posterior pattern specification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
circadian regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
circadian regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
circadian regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
entrainment of circadian clock by photoperiod IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
response to light stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
response to light stimulus ISO
Inferred from Sequence Orthology
more info
 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nuclear body ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
class E basic helix-loop-helix protein 40
Names
E47 interaction protein 1
basic helix-loop-helix domain containing, class B2
class B basic helix-loop-helix protein 2
cytokine response gene 8
differentially expressed in chondrocytes protein 1
eip1 (E47 interaction protein 1)
stimulated by retinoic acid gene 13 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011498.4NP_035628.1  class E basic helix-loop-helix protein 40

    See identical proteins and their annotated locations for NP_035628.1

    Status: VALIDATED

    Source sequence(s)
    AC153593
    Consensus CDS
    CCDS20400.1
    UniProtKB/Swiss-Prot
    O35185
    UniProtKB/TrEMBL
    Q542A5
    Related
    ENSMUSP00000032194.4, ENSMUST00000032194.10
    Conserved Domains (2) summary
    smart00511
    Location:140184
    ORANGE; Orange domain
    cd00083
    Location:50111
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p6 C57BL/6J

    Range
    108660629..108666925
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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