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Bhlhe40 basic helix-loop-helix family, member e40 [ Mus musculus (house mouse) ]

Gene ID: 20893, updated on 5-Mar-2024

Summary

Official Symbol
Bhlhe40provided by MGI
Official Full Name
basic helix-loop-helix family, member e40provided by MGI
Primary source
MGI:MGI:1097714
See related
Ensembl:ENSMUSG00000030103 AllianceGenome:MGI:1097714
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CR8; Dec1; Bhlhb2; Clast5; Sharp2; Stra13; Stra14; C130042M06Rik
Summary
This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with Arntl or compete for E-box binding sites in the promoter of Per1 and repress Clock/Arntl's transactivation of Per1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. [provided by RefSeq, Feb 2014]
Expression
Ubiquitous expression in adrenal adult (RPKM 15.2), kidney adult (RPKM 15.1) and 27 other tissues See more
Orthologs
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Genomic context

See Bhlhe40 in Genome Data Viewer
Location:
6 E2; 6 49.85 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (108637590..108643886)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (108660629..108666925)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene inositol 1,4,5-trisphosphate receptor 1 Neighboring gene STARR-positive B cell enhancer mm9_chr6:108499461-108499762 Neighboring gene STARR-positive B cell enhancer ABC_E4852 Neighboring gene STARR-seq mESC enhancer starr_16963 Neighboring gene predicted gene, 44040 Neighboring gene RIKEN cDNA 0610040F04 gene Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr6:108580835-108581135 Neighboring gene STARR-positive B cell enhancer mm9_chr6:108611576-108611876 Neighboring gene STARR-positive B cell enhancer ABC_E1705 Neighboring gene STARR-seq mESC enhancer starr_16978 Neighboring gene predicted gene, 35359 Neighboring gene STARR-positive B cell enhancer ABC_E8121 Neighboring gene STARR-positive B cell enhancer ABC_E6466 Neighboring gene predicted gene, 51409 Neighboring gene ADP-ribosylation factor-like 8B Neighboring gene predicted gene, 35417

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables E-box binding IDA
Inferred from Direct Assay
more info
PubMed 
enables E-box binding ISO
Inferred from Sequence Orthology
more info
 
enables MRF binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables bHLH transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in anterior/posterior pattern specification IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in circadian regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in circadian regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in circadian regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
involved_in entrainment of circadian clock by photoperiod IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to light stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
class E basic helix-loop-helix protein 40
Names
E47 interaction protein 1
basic helix-loop-helix domain containing, class B2
class B basic helix-loop-helix protein 2
cytokine response gene 8
differentially expressed in chondrocytes protein 1
eip1 (E47 interaction protein 1)
stimulated by retinoic acid gene 13 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011498.4NP_035628.1  class E basic helix-loop-helix protein 40

    See identical proteins and their annotated locations for NP_035628.1

    Status: VALIDATED

    Source sequence(s)
    AC153593
    Consensus CDS
    CCDS20400.1
    UniProtKB/Swiss-Prot
    O35185, P97289
    UniProtKB/TrEMBL
    Q542A5
    Related
    ENSMUSP00000032194.5, ENSMUST00000032194.11
    Conserved Domains (2) summary
    smart00511
    Location:140184
    ORANGE; Orange domain
    cd19749
    Location:40129
    bHLH-O_DEC1; basic helix-loop-helix-orange (bHLH-O) domain found in differentially expressed in chondrocytes protein 1 (DEC1) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    108637590..108643886
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)