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Slc26a7 solute carrier family 26, member 7 [ Mus musculus (house mouse) ]

Gene ID: 208890, updated on 27-Nov-2024

Summary

Official Symbol
Slc26a7provided by MGI
Official Full Name
solute carrier family 26, member 7provided by MGI
Primary source
MGI:MGI:2384791
See related
Ensembl:ENSMUSG00000040569 AllianceGenome:MGI:2384791
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables chloride channel activity and chloride:bicarbonate antiporter activity. Involved in several processes, including bicarbonate transport; carboxylic acid transport; and inorganic anion transmembrane transport. Acts upstream of or within chloride transport. Located in basolateral plasma membrane. Is expressed in several structures, including alimentary system; brain; limb; respiratory system; and sensory organ. Used to study congenital hypothyroidism. Orthologous to human SLC26A7 (solute carrier family 26 member 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in limb E14.5 (RPKM 6.8), subcutaneous fat pad adult (RPKM 4.1) and 7 other tissues See more
Orthologs
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Genomic context

See Slc26a7 in Genome Data Viewer
Location:
4 A1; 4 6.24 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (14502430..14621946, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (14502430..14621946, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 2560 Neighboring gene predicted gene, 24908 Neighboring gene STARR-seq mESC enhancer starr_09632 Neighboring gene myosin, light polypeptide 6, alkali, smooth muscle and non-muscle pseudogene Neighboring gene STARR-seq mESC enhancer starr_09633 Neighboring gene STARR-seq mESC enhancer starr_09634 Neighboring gene STARR-seq mESC enhancer starr_09635 Neighboring gene STARR-seq mESC enhancer starr_09636 Neighboring gene leucine rich repeat containing 69 Neighboring gene STARR-seq mESC enhancer starr_09637 Neighboring gene OTU domain containing 6B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC30955

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables bicarbonate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables bicarbonate transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables chloride channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables chloride channel activity ISO
Inferred from Sequence Orthology
more info
 
enables chloride transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chloride:bicarbonate antiporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables chloride:bicarbonate antiporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables chloride:bicarbonate antiporter activity ISO
Inferred from Sequence Orthology
more info
 
enables monoatomic anion channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables oxalate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables oxalate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables oxalate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables sulfate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sulfate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables sulfate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in bicarbonate transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in bicarbonate transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within chloride transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chloride transport ISO
Inferred from Sequence Orthology
more info
 
involved_in gastric acid secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in gluconate transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in iodide transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in iodide transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in iodide transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monoatomic anion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nitrate transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in oxalate transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in oxalate transport ISO
Inferred from Sequence Orthology
more info
 
involved_in sulfate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sulfate transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sulfate transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in thyroid hormone generation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in membrane IC
Inferred by Curator
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in recycling endosome membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
anion exchange transporter
Names
anion exchanger Slc26a7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145947.2NP_666059.2  anion exchange transporter

    See identical proteins and their annotated locations for NP_666059.2

    Status: VALIDATED

    Source sequence(s)
    AF345194, AK054327
    Consensus CDS
    CCDS17979.1
    UniProtKB/Swiss-Prot
    A2AJZ4, B1AWS0, Q8R2Z3
    Related
    ENSMUSP00000041789.8, ENSMUST00000042221.14
    Conserved Domains (2) summary
    cd07042
    Location:495632
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    TIGR00815
    Location:33637
    sulP; high affinity sulphate transporter 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    14502430..14621946 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537723.4XP_006537786.1  anion exchange transporter isoform X1

    See identical proteins and their annotated locations for XP_006537786.1

    Conserved Domains (2) summary
    cd07042
    Location:533668
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    pfam00916
    Location:47444
    Sulfate_transp; Sulfate permease family
  2. XM_006537722.4XP_006537785.1  anion exchange transporter isoform X1

    See identical proteins and their annotated locations for XP_006537785.1

    Conserved Domains (2) summary
    cd07042
    Location:533668
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    pfam00916
    Location:47444
    Sulfate_transp; Sulfate permease family