U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Sde2 SDE2 telomere maintenance homolog (S. pombe) [ Mus musculus (house mouse) ]

Gene ID: 208768, updated on 5-Jan-2023

Summary

Official Symbol
Sde2provided by MGI
Official Full Name
SDE2 telomere maintenance homolog (S. pombe)provided by MGI
Primary source
MGI:MGI:2384788
See related
Ensembl:ENSMUSG00000038806 AllianceGenome:MGI:2384788
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable damaged DNA binding activity. Predicted to be involved in several processes, including cellular response to UV; mitotic G1 DNA damage checkpoint signaling; and protein ubiquitination. Predicted to act upstream of or within DNA replication and cell division. Predicted to be located in several cellular components, including Golgi apparatus; cytosol; and nuclear speck. Predicted to be active in nucleus. Is expressed in submandibular gland primordium and thymus primordium. Orthologous to human SDE2 (SDE2 telomere maintenance homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 11.0), CNS E11.5 (RPKM 10.1) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Sde2 in Genome Data Viewer
Location:
1; 1 H4
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (180678716..180695678)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (180851151..180868113)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene H3.3 histone A Neighboring gene RIKEN cDNA G370120E05 gene Neighboring gene predicted gene, 24836 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide K pseudogene Neighboring gene predicted gene, 18036 Neighboring gene predicted gene, 39714

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC30618

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables damaged DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables snoRNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to UV ISO
Inferred from Sequence Orthology
more info
 
involved_in endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISO
Inferred from Sequence Orthology
more info
 
involved_in mRNA cis splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic G1 DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in protein processing ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
splicing regulator SDE2
Names
UPF0667 protein C1orf55 homolog
protein SDE2 homolog
replication stress response regulator SDE2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145943.1NP_666055.1  splicing regulator SDE2

    See identical proteins and their annotated locations for NP_666055.1

    Status: PROVISIONAL

    Source sequence(s)
    BC031781
    Consensus CDS
    CCDS15574.1
    UniProtKB/Swiss-Prot
    Q8BJX1, Q8K1J5
    Related
    ENSMUSP00000037890.7, ENSMUST00000038091.8
    Conserved Domains (2) summary
    pfam13297
    Location:382441
    Telomere_Sde2_2; Telomere stability C-terminal
    cl00155
    Location:69146
    UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    180678716..180695678
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)