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Sde2 SDE2 telomere maintenance homolog (S. pombe) [ Mus musculus (house mouse) ]

Gene ID: 208768, updated on 7-Aug-2026
Official Symbol
Sde2provided by MGI
Official Full Name
SDE2 telomere maintenance homolog (S. pombe)provided by MGI
Primary source
MGI:MGI:2384788
See related
Ensembl:ENSMUSG00000038806 AllianceGenome:MGI:2384788
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable damaged DNA binding activity and snoRNA binding activity. Predicted to be involved in several processes, including cellular response to UV; gene expression; and mitotic G1 DNA damage checkpoint signaling. Predicted to be located in several cellular components, including Golgi apparatus; cytosol; and nuclear speck. Predicted to be active in nucleus. Is expressed in submandibular gland primordium and thymus primordium. Orthologous to human SDE2 (SDE2 telomere maintenance homolog). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in liver E14 (RPKM 11.0), CNS E11.5 (RPKM 10.1) and 28 other tissues See more
Orthologs
all
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See Sde2 in Genome Data Viewer
Location:
1 H4; 1 84.46 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (180678716..180695678)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (180851151..180868113)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene H3.3 histone A Neighboring gene STARR-positive B cell enhancer mm9_chr1:182741166-182741467 Neighboring gene STARR-positive B cell enhancer mm9_chr1:182741619-182741920 Neighboring gene STARR-positive B cell enhancer mm9_chr1:182743672-182743973 Neighboring gene RIKEN cDNA G370120E05 gene Neighboring gene predicted gene, 24836 Neighboring gene STARR-positive B cell enhancer ABC_E5873 Neighboring gene STARR-positive B cell enhancer ABC_E3343 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide K pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:182805483-182805670 Neighboring gene predicted gene, 18036 Neighboring gene predicted gene, 39714 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:182814007-182814116

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor. Pilot-Storck F, et al. Mol Cell Proteomics, 2010 Jul. PMID 20368287, Free PMC Article
  2. Systematic identification of factors for provirus silencing in embryonic stem cells. Yang BX, et al. Cell, 2015 Sep 24. PMID 26365490, Free PMC Article
  3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC30618

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables damaged DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables damaged DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables snoRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables snoRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables snoRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables snoRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cellular response to UV IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to UV ISO
Inferred from Sequence Orthology
more info
  
involved_in endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA
Inferred from Electronic Annotation
more info
  
involved_in endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISO
Inferred from Sequence Orthology
more info
  
involved_in endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mRNA cis splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA cis splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA cis splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA cis splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitotic G1 DNA damage checkpoint signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic G1 DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in protein processing IEA
Inferred from Electronic Annotation
more info
  
involved_in protein processing ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of post-mRNA release spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
splicing regulator SDE2
Names
UPF0667 protein C1orf55 homolog
protein SDE2 homolog
replication stress response regulator SDE2

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145943.1 → NP_666055.1  splicing regulator SDE2

    See identical proteins and their annotated locations for NP_666055.1

    Status: PROVISIONAL

    Source sequence(s)
    BC031781
    Consensus CDS
    CCDS15574.1
    UniProtKB/Swiss-Prot
    Q8BJX1, Q8K1J5
    Related
    ENSMUSP00000037890.7, ENSMUST00000038091.9
    Conserved Domains (2) summary
    pfam13297
    Location:382 → 441
    Telomere_Sde2_2; Telomere stability C-terminal
    cl00155
    Location:69 → 146
    UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    180678716..180695678
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K1J5.1 GenPept UniProtKB/Swiss-Prot:Q8K1J5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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