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Prrg3 proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane) [ Mus musculus (house mouse) ]

Gene ID: 208748, updated on 8-Dec-2022

Summary

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Official Symbol
Prrg3provided by MGI
Official Full Name
proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane)provided by MGI
Primary source
MGI:MGI:2685214
See related
Ensembl:ENSMUSG00000033361 AllianceGenome:MGI:2685214
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm368
Summary
This gene encodes proline-rich gamma-carboxyglutamic acid protein 3, a member of vitamin K-dependent membrane proteins containing gamma-carboxyglutamic acid residues. The encoded precursor protein contains an N-terminal propeptide that is required for the carboxylation of glutamate residues in the mature protein. Alternate splicing of this gene results in multiple transcript variants that encode the same protein. [provided by RefSeq, Dec 2014]
Expression
Biased expression in genital fat pad adult (RPKM 45.8), lung adult (RPKM 10.0) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Prrg3 in Genome Data Viewer
Location:
X; X A7.3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (71005769..71016328)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (71962164..71972722)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene VMA21 vacuolar H+-ATPase homolog (S. cerevisiae) Neighboring gene predicted gene 1141 Neighboring gene fetal and adult testis expressed 1 Neighboring gene cyclic nucleotide gated channel alpha 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of two novel transmembrane gamma-carboxyglutamic acid proteins expressed broadly in fetal and adult tissues. Kulman JD, et al. Proc Natl Acad Sci U S A, 2001 Feb 13. PMID 11171957, Free PMC Article
  2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (14) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane gamma-carboxyglutamic acid protein 3
Names
proline-rich Gla protein 3
proline-rich gamma-carboxyglutamic acid protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081135.2 → NP_001074604.1  transmembrane gamma-carboxyglutamic acid protein 3 precursor

    See identical proteins and their annotated locations for NP_001074604.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL731693, AW488829
    Consensus CDS
    CCDS41001.1
    UniProtKB/Swiss-Prot
    B2RPV1, Q6PAQ9
    UniProtKB/TrEMBL
    A0A8C6I6N1
    Related
    ENSMUSP00000038947.7, ENSMUST00000048790.7
    Conserved Domains (1) summary
    pfam00594
    Location:24 → 63
    Gla; Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain

  2. NM_001303028.1 → NP_001289957.1  transmembrane gamma-carboxyglutamic acid protein 3 precursor

    See identical proteins and their annotated locations for NP_001289957.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR and a shorter 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL731693, AW488829
    Consensus CDS
    CCDS41001.1
    UniProtKB/Swiss-Prot
    B2RPV1, Q6PAQ9
    UniProtKB/TrEMBL
    A0A8C6I6N1
    Related
    ENSMUSP00000128073.2, ENSMUST00000170096.8
    Conserved Domains (1) summary
    pfam00594
    Location:24 → 63
    Gla; Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    71005769..71016328
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527925.5 → XP_006527988.1  transmembrane gamma-carboxyglutamic acid protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006527988.1

    UniProtKB/Swiss-Prot
    B2RPV1, Q6PAQ9
    UniProtKB/TrEMBL
    A0A8C6I6N1
    Conserved Domains (1) summary
    pfam00594
    Location:24 → 63
    Gla; Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain

  2. XM_006527927.5 → XP_006527990.1  transmembrane gamma-carboxyglutamic acid protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006527990.1

    UniProtKB/Swiss-Prot
    B2RPV1, Q6PAQ9
    UniProtKB/TrEMBL
    A0A8C6I6N1
    Conserved Domains (1) summary
    pfam00594
    Location:24 → 63
    Gla; Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain

  3. XM_006527924.5 → XP_006527987.1  transmembrane gamma-carboxyglutamic acid protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006527987.1

    UniProtKB/Swiss-Prot
    B2RPV1, Q6PAQ9
    UniProtKB/TrEMBL
    A0A8C6I6N1
    Conserved Domains (1) summary
    pfam00594
    Location:24 → 63
    Gla; Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain

  4. XM_006527926.4 → XP_006527989.1  transmembrane gamma-carboxyglutamic acid protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006527989.1

    UniProtKB/Swiss-Prot
    B2RPV1, Q6PAQ9
    UniProtKB/TrEMBL
    A0A8C6I6N1
    Conserved Domains (1) summary
    pfam00594
    Location:24 → 63
    Gla; Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PAQ9.2 GenPept UniProtKB/Swiss-Prot:Q6PAQ9

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