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Creb3l2 cAMP responsive element binding protein 3-like 2 [ Mus musculus (house mouse) ]

Gene ID: 208647, updated on 2-Nov-2024

Summary

Official Symbol
Creb3l2provided by MGI
Official Full Name
cAMP responsive element binding protein 3-like 2provided by MGI
Primary source
MGI:MGI:2442695
See related
Ensembl:ENSMUSG00000038648 AllianceGenome:MGI:2442695
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BBF2H7; SCIRR69; C530025K05Rik
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and cAMP response element binding activity. Involved in chondrocyte differentiation; endoplasmic reticulum to Golgi vesicle-mediated transport; and positive regulation of transcription by RNA polymerase II. Predicted to be located in chromatin; nucleoplasm; and perinuclear endoplasmic reticulum. Is expressed in several structures, including central nervous system; early conceptus; embryo mesenchyme; and genitourinary system. Orthologous to human CREB3L2 (cAMP responsive element binding protein 3 like 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in limb E14.5 (RPKM 19.4), adrenal adult (RPKM 18.8) and 27 other tissues See more
Orthologs
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Genomic context

See Creb3l2 in Genome Data Viewer
Location:
6 B1; 6 16.18 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (37307956..37419083, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (37327255..37442276, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene diacylglycerol kinase, iota Neighboring gene predicted gene, 52857 Neighboring gene STARR-seq mESC enhancer starr_15575 Neighboring gene predicted pseudogene 7452 Neighboring gene STARR-seq mESC enhancer starr_15579 Neighboring gene STARR-positive B cell enhancer mm9_chr6:37392120-37392421 Neighboring gene STARR-positive B cell enhancer ABC_E4821 Neighboring gene predicted gene, 33275 Neighboring gene predicted gene, 33318 Neighboring gene STARR-seq mESC enhancer starr_15587 Neighboring gene predicted gene, 33429 Neighboring gene aldo-keto reductase family 1, member D1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in perinuclear endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cyclic AMP-responsive element-binding protein 3-like protein 2
Names
cAMP-responsive element-binding protein 3-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178661.4NP_848776.2  cyclic AMP-responsive element-binding protein 3-like protein 2

    See identical proteins and their annotated locations for NP_848776.2

    Status: VALIDATED

    Source sequence(s)
    AK036712, BC138471, BY202578
    Consensus CDS
    CCDS20006.1
    UniProtKB/Swiss-Prot
    B2RRL0, Q8BH52, Q8CB61, Q8CBN2
    Related
    ENSMUSP00000040208.6, ENSMUST00000041093.6
    Conserved Domains (1) summary
    cd14689
    Location:305348
    bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    37307956..37419083 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)