U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Etl4 enhancer trap locus 4 [ Mus musculus (house mouse) ]

Gene ID: 208618, updated on 12-May-2024

Summary

Official Symbol
Etl4provided by MGI
Official Full Name
enhancer trap locus 4provided by MGI
Primary source
MGI:MGI:95454
See related
Ensembl:ENSMUSG00000036617 AllianceGenome:MGI:95454
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Skt; Etl-4; 6620402G01Rik; 9430077C05Rik; E330027G05Rik
Summary
Involved in embryonic skeletal system development. Located in cytoplasm. Is expressed in several structures, including alimentary system; branchial arch; genitourinary system; limb ectoderm; and sensory organ. Orthologous to human KIAA1217 (KIAA1217). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cortex adult (RPKM 4.1), frontal lobe adult (RPKM 3.9) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Etl4 in Genome Data Viewer
Location:
2 A3; 2 14.27 cM
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (19915018..20815346)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (19910207..20810535)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:19656187-19656410 Neighboring gene STARR-seq mESC enhancer starr_03834 Neighboring gene GTPase activating protein (SH3 domain) binding protein 2 pseudogene Neighboring gene predicted gene, 24670 Neighboring gene STARR-seq mESC enhancer starr_03835 Neighboring gene STARR-seq mESC enhancer starr_03836 Neighboring gene Ngfi-A binding protein 1 pseudogene Neighboring gene predicted gene 13363 Neighboring gene STARR-seq mESC enhancer starr_03837 Neighboring gene voltage-dependent anion channel 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_03838 Neighboring gene STARR-seq mESC enhancer starr_03839 Neighboring gene STARR-seq mESC enhancer starr_03840 Neighboring gene mitochondrial ribosomal protein S5 pseudogene Neighboring gene predicted gene, 23970 Neighboring gene STARR-seq mESC enhancer starr_03841 Neighboring gene STARR-seq mESC enhancer starr_03842 Neighboring gene predicted gene 17171 Neighboring gene predicted gene, 54104 Neighboring gene STARR-seq mESC enhancer starr_03843 Neighboring gene STARR-seq mESC enhancer starr_03846 Neighboring gene CRISPRi-validated Etl4 enhancer cluster Neighboring gene STARR-seq mESC enhancer starr_03863 Neighboring gene STARR-seq mESC enhancer starr_03867 Neighboring gene STARR-seq mESC enhancer starr_03870 Neighboring gene Rho GTPase activating protein 21 Neighboring gene STARR-positive B cell enhancer mm9_chr2:20885831-20886131 Neighboring gene STARR-positive B cell enhancer ABC_E5897 Neighboring gene STARR-seq mESC enhancer starr_03884 Neighboring gene STARR-seq mESC enhancer starr_03887 Neighboring gene VISTA enhancer mm1447 Neighboring gene predicted gene 13375 Neighboring gene STARR-seq mESC enhancer starr_03890 Neighboring gene phosphoribosyltransferase domain containing 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in embryonic skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081006.1NP_001074475.1  sickle tail protein isoform c

    See identical proteins and their annotated locations for NP_001074475.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (c) encodes the longest protein (isoform c).
    Source sequence(s)
    AB125594, AK147510, AL929100, BC158051, CF744489
    Consensus CDS
    CCDS38053.1
    UniProtKB/TrEMBL
    E9QAU4
    Related
    ENSMUSP00000110274.2, ENSMUST00000114627.8
    Conserved Domains (1) summary
    pfam03915
    Location:239317
    AIP3; Actin interacting protein 3
  2. NM_001177630.2NP_001171101.2  sickle tail protein isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (d) has multiple differences, compared to variant c. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant c. The encoded protein (isoform d) is shorter when it is compared to isoform c.
    Source sequence(s)
    AB125594, AL929100, BB040164, BC158051
    Consensus CDS
    CCDS50509.1
    UniProtKB/TrEMBL
    B2RY09, D3Z781
    Related
    ENSMUSP00000110251.3, ENSMUST00000114604.9
    Conserved Domains (1) summary
    pfam03915
    Location:188259
    AIP3; Actin interacting protein 3
  3. NM_001177631.1NP_001171102.1  sickle tail protein isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (e) has multiple differences, compared to variant c. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant c. The encoded protein (isoform e) is shorter when it is compared to isoform c.
    Source sequence(s)
    AK147510, AL844538, AL929100, BC158051, BC172143
    UniProtKB/TrEMBL
    B2RY09
    Conserved Domains (1) summary
    pfam03915
    Location:188259
    AIP3; Actin interacting protein 3
  4. NM_001369134.1NP_001356063.1  sickle tail protein isoform f

    Status: VALIDATED

    Source sequence(s)
    AL844538, AL929100
    Consensus CDS
    CCDS89430.1
    UniProtKB/Swiss-Prot
    A2AQ25, A2AUE9, A2AUF0, A2AUF1, Q75UV8, Q75UV9, Q80VK2, Q8BHX8, Q8BHY1, Q8CHA8, Q8R0K6
    Related
    ENSMUSP00000066170.4, ENSMUST00000066509.10
    Conserved Domains (1) summary
    pfam03915
    Location:188266
    AIP3; Actin interacting protein 3
  5. NM_029895.4NP_084171.2  sickle tail protein isoform b

    See identical proteins and their annotated locations for NP_084171.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (b) has multiple differences, compared to variant c. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant c. The encoded protein (isoform b) is shorter when it is compared to isoform c.
    Source sequence(s)
    AB125595, AL929100
    Consensus CDS
    CCDS50510.1
    UniProtKB/TrEMBL
    B2RY09
    Related
    ENSMUSP00000110261.2, ENSMUST00000114614.8
    Conserved Domains (1) summary
    pfam03915
    Location:188259
    AIP3; Actin interacting protein 3
  6. NM_178059.5NP_835160.2  sickle tail protein isoform a

    See identical proteins and their annotated locations for NP_835160.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (a) has multiple differences, compared to variant c. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant c. The encoded protein (isoform a) is shorter when it is compared to isoform c.
    Source sequence(s)
    AB125594, AL929100
    Consensus CDS
    CCDS50511.1
    UniProtKB/TrEMBL
    B2RY09
    Related
    ENSMUSP00000041431.5, ENSMUST00000045555.11
    Conserved Domains (2) summary
    pfam03915
    Location:188266
    AIP3; Actin interacting protein 3
    NF033930
    Location:644909
    pneumo_PspA; pneumococcal surface protein A

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    19915018..20815346
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160115.1XP_036016008.1  sickle tail protein isoform X1

    Conserved Domains (2) summary
    pfam03915
    Location:266344
    AIP3; Actin interacting protein 3
    NF033930
    Location:7571022
    pneumo_PspA; pneumococcal surface protein A
  2. XM_006497408.4XP_006497471.1  sickle tail protein isoform X2

    See identical proteins and their annotated locations for XP_006497471.1

    UniProtKB/TrEMBL
    E9QAU4
    Conserved Domains (1) summary
    pfam03915
    Location:239317
    AIP3; Actin interacting protein 3
  3. XM_006497428.3XP_006497491.1  sickle tail protein isoform X12

    UniProtKB/TrEMBL
    B2RY09
    Conserved Domains (1) summary
    pfam03915
    Location:239317
    AIP3; Actin interacting protein 3
  4. XM_006497427.3XP_006497490.1  sickle tail protein isoform X11

    UniProtKB/TrEMBL
    B2RY09
    Conserved Domains (1) summary
    pfam03915
    Location:239317
    AIP3; Actin interacting protein 3
  5. XM_036160127.1XP_036016020.1  sickle tail protein isoform X5

    Conserved Domains (2) summary
    pfam03915
    Location:108186
    AIP3; Actin interacting protein 3
    NF033930
    Location:599864
    pneumo_PspA; pneumococcal surface protein A
  6. XM_036160128.1XP_036016021.1  sickle tail protein isoform X5

    Conserved Domains (2) summary
    pfam03915
    Location:108186
    AIP3; Actin interacting protein 3
    NF033930
    Location:599864
    pneumo_PspA; pneumococcal surface protein A
  7. XM_036160138.1XP_036016031.1  sickle tail protein isoform X13

    UniProtKB/TrEMBL
    B2RY09
    Conserved Domains (2) summary
    pfam03915
    Location:188266
    AIP3; Actin interacting protein 3
    NF033930
    Location:679944
    pneumo_PspA; pneumococcal surface protein A
  8. XM_036160141.1XP_036016034.1  sickle tail protein isoform X15

    UniProtKB/TrEMBL
    B2RY09
    Conserved Domains (2) summary
    pfam03915
    Location:188266
    AIP3; Actin interacting protein 3
    NF033930
    Location:644909
    pneumo_PspA; pneumococcal surface protein A
  9. XM_036160144.1XP_036016037.1  sickle tail protein isoform X17

    UniProtKB/TrEMBL
    B2RY09
    Conserved Domains (2) summary
    pfam03915
    Location:188266
    AIP3; Actin interacting protein 3
    NF033930
    Location:644909
    pneumo_PspA; pneumococcal surface protein A
  10. XM_036160139.1XP_036016032.1  sickle tail protein isoform X14

    UniProtKB/TrEMBL
    B2RY09
    Conserved Domains (2) summary
    pfam03915
    Location:188266
    AIP3; Actin interacting protein 3
    NF033930
    Location:679944
    pneumo_PspA; pneumococcal surface protein A
  11. XM_036160142.1XP_036016035.1  sickle tail protein isoform X16

    UniProtKB/TrEMBL
    B2RY09
    Conserved Domains (2) summary
    pfam03915
    Location:188266
    AIP3; Actin interacting protein 3
    NF033930
    Location:679944
    pneumo_PspA; pneumococcal surface protein A
  12. XM_036160147.1XP_036016040.1  sickle tail protein isoform X18

    UniProtKB/TrEMBL
    B2RY09
    Conserved Domains (2) summary
    pfam03915
    Location:188266
    AIP3; Actin interacting protein 3
    NF033930
    Location:644909
    pneumo_PspA; pneumococcal surface protein A
  13. XM_036160119.1XP_036016012.1  sickle tail protein isoform X3

    Conserved Domains (2) summary
    pfam03915
    Location:215293
    AIP3; Actin interacting protein 3
    NF033930
    Location:706971
    pneumo_PspA; pneumococcal surface protein A
  14. XM_036160124.1XP_036016017.1  sickle tail protein isoform X4

    Conserved Domains (2) summary
    pfam03915
    Location:215293
    AIP3; Actin interacting protein 3
    NF033930
    Location:671936
    pneumo_PspA; pneumococcal surface protein A
  15. XM_006497419.4XP_006497482.1  sickle tail protein isoform X7

    Conserved Domains (1) summary
    pfam03915
    Location:38116
    AIP3; Actin interacting protein 3
  16. XM_036160150.1XP_036016043.1  sickle tail protein isoform X19

    UniProtKB/TrEMBL
    B2RY09
    Conserved Domains (2) summary
    pfam03915
    Location:38116
    AIP3; Actin interacting protein 3
    NF033930
    Location:529794
    pneumo_PspA; pneumococcal surface protein A
  17. XM_006497417.5XP_006497480.1  sickle tail protein isoform X6

    Conserved Domains (1) summary
    pfam03915
    Location:104182
    AIP3; Actin interacting protein 3
  18. XM_017316832.3XP_017172321.1  sickle tail protein isoform X20

    Conserved Domains (1) summary
    NF033930
    Location:397662
    pneumo_PspA; pneumococcal surface protein A
  19. XM_006497422.5XP_006497485.1  sickle tail protein isoform X8

    See identical proteins and their annotated locations for XP_006497485.1

  20. XM_006497424.5XP_006497487.1  sickle tail protein isoform X9

    UniProtKB/Swiss-Prot
    A2AQ25
  21. XM_036160131.1XP_036016024.1  sickle tail protein isoform X10

    Conserved Domains (1) summary
    NF033930
    Location:362627
    pneumo_PspA; pneumococcal surface protein A
  22. XM_036160151.1XP_036016044.1  sickle tail protein isoform X22

    Related
    ENSMUSP00000110253.2, ENSMUST00000114606.8
    Conserved Domains (1) summary
    NF033930
    Location:362627
    pneumo_PspA; pneumococcal surface protein A
  23. XM_017316833.3XP_017172322.1  sickle tail protein isoform X21

  24. XM_006497423.5XP_006497486.1  sickle tail protein isoform X8

    See identical proteins and their annotated locations for XP_006497486.1

    Conserved Domains (2) summary
    PHA02682
    Location:16103
    PHA02682; ORF080 virion core protein; Provisional
    pfam09606
    Location:549666
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  25. XM_030249074.2XP_030104934.1  sickle tail protein isoform X9

    Related
    ENSMUSP00000110255.2, ENSMUST00000114608.3
  26. XM_036160152.1XP_036016045.1  sickle tail protein isoform X20

    Conserved Domains (1) summary
    NF033930
    Location:397662
    pneumo_PspA; pneumococcal surface protein A