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Stat3 signal transducer and activator of transcription 3 [ Mus musculus (house mouse) ]

Gene ID: 20848, updated on 27-Jan-2020

Summary

Official Symbol
Stat3provided by MGI
Official Full Name
signal transducer and activator of transcription 3provided by MGI
Primary source
MGI:MGI:103038
See related
Ensembl:ENSMUSG00000004040
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Aprf; AW109958; 1110034C02Rik
Summary
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]
Expression
Ubiquitous expression in lung adult (RPKM 48.1), mammary gland adult (RPKM 46.4) and 28 other tissues See more
Orthologs

Genomic context

See Stat3 in Genome Data Viewer
Location:
11 D; 11 63.82 cM
Exon count:
24
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100886806..100939594, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (100748124..100800825, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene signal transducer and activator of transcription 5B Neighboring gene signal transducer and activator of transcription 5A Neighboring gene predicted gene, 46295 Neighboring gene caveolae associated 1 Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit A1 Neighboring gene microRNA 6928

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
CCR5 chemokine receptor binding ISO
Inferred from Sequence Orthology
more info
 
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II repressing transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
chromatin DNA binding ISO
Inferred from Sequence Orthology
more info
 
glucocorticoid receptor binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
nuclear receptor activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
JAK-STAT cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
JAK-STAT cascade TAS
Traceable Author Statement
more info
PubMed 
JAK-STAT cascade involved in growth hormone signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
JAK-STAT cascade involved in growth hormone signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
JAK-STAT cascade involved in growth hormone signaling pathway ISO
Inferred from Sequence Orthology
more info
 
T-helper 17 cell lineage commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
acute-phase response IEA
Inferred from Electronic Annotation
more info
 
astrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to cytokine stimulus ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to leptin stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
PubMed 
cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine-mediated signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
defense response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
eating behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
energy homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
eye photoreceptor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
growth hormone receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
interleukin-6-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
intracellular receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
leptin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
leptin-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
leptin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
leptin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
mRNA transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
miRNA mediated inhibition of translation ISO
Inferred from Sequence Orthology
more info
 
modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of glycolytic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of hydrogen peroxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron migration IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ATP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene silencing by miRNA ISO
Inferred from Sequence Orthology
more info
 
positive regulation of growth factor dependent skeletal muscle satellite cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-6 biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of metalloendopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of pri-miRNA transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of pri-miRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vascular endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
postsynapse to nucleus signaling pathway ISO
Inferred from Sequence Orthology
more info
 
protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
radial glial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of feeding behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitochondrial membrane permeability ISO
Inferred from Sequence Orthology
more info
 
regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
response to cytokine ISO
Inferred from Sequence Orthology
more info
 
response to estradiol ISO
Inferred from Sequence Orthology
more info
 
response to leptin IDA
Inferred from Direct Assay
more info
PubMed 
response to leptin IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to leptin ISO
Inferred from Sequence Orthology
more info
 
response to peptide hormone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sexual reproduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
temperature homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
RNA polymerase II transcription factor complex ISO
Inferred from Sequence Orthology
more info
 
Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nuclear chromatin ISO
Inferred from Sequence Orthology
more info
 
nuclear transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
transcription factor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
signal transducer and activator of transcription 3
Names
acute phase response factor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011486.5NP_035616.1  signal transducer and activator of transcription 3 isoform 3

    See identical proteins and their annotated locations for NP_035616.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also called Stat3B or Stat3beta, uses an alternate splice site in the 3' coding region, resulting in an early stop codon, compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL591466
    Consensus CDS
    CCDS25441.1
    UniProtKB/TrEMBL
    Q6GU23
    Related
    ENSMUSP00000099403.1, ENSMUST00000103114.7
    Conserved Domains (4) summary
    cd10374
    Location:554715
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
  2. NM_213659.3NP_998824.1  signal transducer and activator of transcription 3 isoform 1

    See identical proteins and their annotated locations for NP_998824.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA123454, AK145486, AK153170, AL591466
    Consensus CDS
    CCDS25440.1
    UniProtKB/Swiss-Prot
    P42227
    UniProtKB/TrEMBL
    Q3ULI4
    Related
    ENSMUSP00000120152.1, ENSMUST00000127638.7
    Conserved Domains (4) summary
    cd10374
    Location:554715
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
  3. NM_213660.3NP_998825.1  signal transducer and activator of transcription 3 isoform 2

    See identical proteins and their annotated locations for NP_998825.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL591466
    Consensus CDS
    CCDS48934.1
    UniProtKB/Swiss-Prot
    P42227
    Related
    ENSMUSP00000090342.5, ENSMUST00000092671.11
    Conserved Domains (4) summary
    cd10374
    Location:554714
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p6 C57BL/6J

    Range
    100886806..100939594 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248846.3XP_011247148.1  signal transducer and activator of transcription 3 isoform X1

    See identical proteins and their annotated locations for XP_011247148.1

    Conserved Domains (4) summary
    cd10374
    Location:554714
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
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