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Sgms1 sphingomyelin synthase 1 [ Mus musculus (house mouse) ]

Gene ID: 208449, updated on 14-Aug-2019

Summary

Official Symbol
Sgms1provided by MGI
Official Full Name
sphingomyelin synthase 1provided by MGI
Primary source
MGI:MGI:2444110
See related
Ensembl:ENSMUSG00000040451
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mob; Sms1; Sor1; C80702; Tmem23; AI841905; 9530058O11Rik
Expression
Broad expression in testis adult (RPKM 37.1), genital fat pad adult (RPKM 8.2) and 20 other tissues See more
Orthologs

Genomic context

See Sgms1 in Genome Data Viewer
Location:
19; 19 C1
Exon count:
25
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (32122727..32389885, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (32197217..32462944, complement)

Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene N-acylsphingosine amidohydrolase 2 Neighboring gene VISTA enhancer mm1654 Neighboring gene coiled-coil domain containing 111 pseudogene Neighboring gene RIKEN cDNA 2700046G09 gene Neighboring gene predicted gene, 38616 Neighboring gene cytokine induced apoptosis inhibitor 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Clone Names

  • MGC30540

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ceramide cholinephosphotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ceramide cholinephosphotransferase activity ISO
Inferred from Sequence Orthology
more info
 
ceramide cholinephosphotransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
ceramide phosphoethanolamine synthase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
ceramide phosphoethanolamine synthase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
sphingomyelin synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sphingomyelin synthase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
sphingomyelin synthase activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
ceramide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ceramide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
ceramide biosynthetic process ISO
Inferred from Sequence Orthology
more info
PubMed 
inflammatory response ISO
Inferred from Sequence Orthology
more info
 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
sphingolipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
sphingomyelin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sphingomyelin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
sphingomyelin biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
Golgi trans cisterna ISO
Inferred from Sequence Orthology
more info
PubMed 
endoplasmic reticulum TAS
Traceable Author Statement
more info
PubMed 
integral component of Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
integral component of endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
phosphatidylcholine:ceramide cholinephosphotransferase 1
Names
protein Mob
transmembrane protein 23
NP_001161997.1
NP_001161998.1
NP_001349352.1
NP_659041.3
XP_006526881.1
XP_006526882.1
XP_006526883.1
XP_011245504.1
XP_011245505.1
XP_011245507.1
XP_017173594.1
XP_030106691.1
XP_030106692.1
XP_030106693.1
XP_030106694.1
XP_030106695.1
XP_030106696.1
XP_030106697.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168525.1NP_001161997.1  phosphatidylcholine:ceramide cholinephosphotransferase 1

    See identical proteins and their annotated locations for NP_001161997.1

    Status: VALIDATED

    Source sequence(s)
    BC076618, BP768024
    Consensus CDS
    CCDS29750.1
    UniProtKB/Swiss-Prot
    Q8VCQ6
    Related
    ENSMUSP00000117336.1, ENSMUST00000142618.7
    Conserved Domains (2) summary
    cd09514
    Location:778
    SAM_SGMS1; SAM domain of sphingomyelin synthase
    pfam14360
    Location:282355
    PAP2_C; PAP2 superfamily C-terminal
  2. NM_001168526.1NP_001161998.1  phosphatidylcholine:ceramide cholinephosphotransferase 1

    See identical proteins and their annotated locations for NP_001161998.1

    Status: VALIDATED

    Source sequence(s)
    AC113485, AK146782, AK152312, BP768024
    Consensus CDS
    CCDS29750.1
    UniProtKB/Swiss-Prot
    Q8VCQ6
    Related
    ENSMUSP00000123395.1, ENSMUST00000151289.8
    Conserved Domains (2) summary
    cd09514
    Location:778
    SAM_SGMS1; SAM domain of sphingomyelin synthase
    pfam14360
    Location:282355
    PAP2_C; PAP2 superfamily C-terminal
  3. NM_001362423.1NP_001349352.1  phosphatidylcholine:ceramide cholinephosphotransferase 1

    Status: VALIDATED

    Source sequence(s)
    AC113485, AC115752, AC124323, AC158130, BP768024
    Conserved Domains (2) summary
    cd09514
    Location:778
    SAM_SGMS1; SAM domain of sphingomyelin synthase
    pfam14360
    Location:282355
    PAP2_C; PAP2 superfamily C-terminal
  4. NM_144792.5NP_659041.3  phosphatidylcholine:ceramide cholinephosphotransferase 1

    See identical proteins and their annotated locations for NP_659041.3

    Status: VALIDATED

    Source sequence(s)
    AC115752, AK146782, AK153406, BP768024
    Consensus CDS
    CCDS29750.1
    UniProtKB/Swiss-Prot
    Q8VCQ6
    Related
    ENSMUSP00000097114.3, ENSMUST00000099514.9
    Conserved Domains (2) summary
    cd09514
    Location:778
    SAM_SGMS1; SAM domain of sphingomyelin synthase
    pfam14360
    Location:282355
    PAP2_C; PAP2 superfamily C-terminal

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000085.6 Reference GRCm38.p6 C57BL/6J

    Range
    32122727..32389885 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247202.3XP_011245504.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_011245504.1

    UniProtKB/Swiss-Prot
    Q8VCQ6
    Conserved Domains (2) summary
    cd09514
    Location:778
    SAM_SGMS1; SAM domain of sphingomyelin synthase
    pfam14360
    Location:282355
    PAP2_C; PAP2 superfamily C-terminal
  2. XM_030250831.1XP_030106691.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

  3. XM_030250833.1XP_030106693.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

  4. XM_030250832.1XP_030106692.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

  5. XM_006526819.2XP_006526882.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006526882.1

    UniProtKB/Swiss-Prot
    Q8VCQ6
    Conserved Domains (2) summary
    cd09514
    Location:778
    SAM_SGMS1; SAM domain of sphingomyelin synthase
    pfam14360
    Location:282355
    PAP2_C; PAP2 superfamily C-terminal
  6. XM_030250837.1XP_030106697.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

  7. XM_011247203.3XP_011245505.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_011245505.1

    UniProtKB/Swiss-Prot
    Q8VCQ6
    Conserved Domains (2) summary
    cd09514
    Location:778
    SAM_SGMS1; SAM domain of sphingomyelin synthase
    pfam14360
    Location:282355
    PAP2_C; PAP2 superfamily C-terminal
  8. XM_030250836.1XP_030106696.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

  9. XM_030250834.1XP_030106694.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

  10. XM_006526818.4XP_006526881.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006526881.1

    UniProtKB/Swiss-Prot
    Q8VCQ6
    Conserved Domains (2) summary
    cd09514
    Location:778
    SAM_SGMS1; SAM domain of sphingomyelin synthase
    pfam14360
    Location:282355
    PAP2_C; PAP2 superfamily C-terminal
  11. XM_030250835.1XP_030106695.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

  12. XM_006526820.4XP_006526883.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006526883.1

    UniProtKB/Swiss-Prot
    Q8VCQ6
    Conserved Domains (2) summary
    cd09514
    Location:778
    SAM_SGMS1; SAM domain of sphingomyelin synthase
    pfam14360
    Location:282355
    PAP2_C; PAP2 superfamily C-terminal
  13. XM_011247205.2XP_011245507.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X2

    Related
    ENSMUSP00000157976.1, ENSMUST00000236410.1
    Conserved Domains (2) summary
    cd09514
    Location:778
    SAM_SGMS1; SAM domain of sphingomyelin synthase
    smart00454
    Location:1074
    SAM; Sterile alpha motif
  14. XM_017318105.2XP_017173594.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X3

    UniProtKB/Swiss-Prot
    Q8VCQ6
    Related
    ENSMUSP00000119869.1, ENSMUST00000152340.7
    Conserved Domains (2) summary
    cd09514
    Location:778
    SAM_SGMS1; SAM domain of sphingomyelin synthase
    smart00454
    Location:1074
    SAM; Sterile alpha motif

RNA

  1. XR_001782565.2 RNA Sequence

  2. XR_001782566.2 RNA Sequence

  3. XR_003952764.1 RNA Sequence

  4. XR_003952765.1 RNA Sequence

  5. XR_003952766.1 RNA Sequence

  6. XR_003952768.1 RNA Sequence

  7. XR_003952767.1 RNA Sequence

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