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Ssrp1 structure specific recognition protein 1 [ Mus musculus (house mouse) ]

Gene ID: 20833, updated on 18-Jun-2024

Summary

Official Symbol
Ssrp1provided by MGI
Official Full Name
structure specific recognition protein 1provided by MGI
Primary source
MGI:MGI:107912
See related
Ensembl:ENSMUSG00000027067 AllianceGenome:MGI:107912
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
T160; Hmgox; Hmg1-rs1; Hmgi-rs3
Summary
Enables chromatin binding activity. Predicted to be involved in regulation of chromatin organization. Predicted to act upstream of or within DNA repair and DNA replication. Predicted to be located in chromosome and nucleus. Predicted to be part of FACT complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human SSRP1 (structure specific recognition protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 88.2), liver E14 (RPKM 67.8) and 28 other tissues See more
Orthologs
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Genomic context

See Ssrp1 in Genome Data Viewer
Location:
2 D; 2 49.45 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (84867519..84877453)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (85037120..85047114)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39868 Neighboring gene proteoglycan 3 Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 3 Neighboring gene STARR-positive B cell enhancer ABC_E225 Neighboring gene tankyrase 1 binding protein 1 Neighboring gene RIKEN cDNA 4930443O20 gene Neighboring gene STARR-seq mESC enhancer starr_05013

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in nucleosome assembly NAS
Non-traceable Author Statement
more info
PubMed 
involved_in nucleosome disassembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of chromatin organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of chromatin organization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of FACT complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of FACT complex ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
FACT complex subunit SSRP1
Names
facilitates chromatin transcription complex subunit SSRP1
recombination signal sequence recognition protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136081.3NP_001129553.1  FACT complex subunit SSRP1

    See identical proteins and their annotated locations for NP_001129553.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' exon structure and differs in the 5' UTR compared to variant 4. All five variants encode the same protein.
    Source sequence(s)
    AL935159, BX546441
    Consensus CDS
    CCDS38165.1
    UniProtKB/Swiss-Prot
    Q08943, Q3U9Z2, Q3UJ75, Q4V9U4, Q8CGA6
    UniProtKB/TrEMBL
    A2AW05
    Related
    ENSMUSP00000127058.2, ENSMUST00000168266.8
    Conserved Domains (2) summary
    COG5165
    Location:21480
    POB3; Nucleosome-binding factor SPN, POB3 subunit [Transcription / DNA replication, recombination, and repair / Chromatin structure and dynamics]
    pfam00505
    Location:547614
    HMG_box; HMG (high mobility group) box
  2. NM_001421071.1NP_001408000.1  FACT complex subunit SSRP1

    Status: VALIDATED

    Source sequence(s)
    AL935159, BX546441
    UniProtKB/Swiss-Prot
    Q08943, Q3U9Z2, Q3UJ75, Q4V9U4, Q8CGA6
    UniProtKB/TrEMBL
    A2AW05
  3. NM_001421072.1NP_001408001.1  FACT complex subunit SSRP1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript. All five variants encode the same protein.
    Source sequence(s)
    AL935159, BX546441
    UniProtKB/Swiss-Prot
    Q08943, Q3U9Z2, Q3UJ75, Q4V9U4, Q8CGA6
    UniProtKB/TrEMBL
    A2AW05
  4. NM_001421073.1NP_001408002.1  FACT complex subunit SSRP1

    Status: VALIDATED

    Source sequence(s)
    AL935159, BX546441
    UniProtKB/Swiss-Prot
    Q08943, Q3U9Z2, Q3UJ75, Q4V9U4, Q8CGA6
    UniProtKB/TrEMBL
    A2AW05
  5. NM_182990.5NP_892035.2  FACT complex subunit SSRP1

    See identical proteins and their annotated locations for NP_892035.2

    Status: VALIDATED

    Source sequence(s)
    AL935159, BX546441
    Consensus CDS
    CCDS38165.1
    UniProtKB/Swiss-Prot
    Q08943, Q3U9Z2, Q3UJ75, Q4V9U4, Q8CGA6
    UniProtKB/TrEMBL
    A2AW05
    Related
    ENSMUSP00000076971.7, ENSMUST00000077798.13
    Conserved Domains (2) summary
    COG5165
    Location:21480
    POB3; Nucleosome-binding factor SPN, POB3 subunit [Transcription / DNA replication, recombination, and repair / Chromatin structure and dynamics]
    pfam00505
    Location:547614
    HMG_box; HMG (high mobility group) box

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    84867519..84877453
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239405.2XP_011237707.1  FACT complex subunit SSRP1 isoform X2

    Conserved Domains (1) summary
    COG5165
    Location:21436
    POB3; Nucleosome-binding factor SPN, POB3 subunit [Transcription / DNA replication, recombination, and repair / Chromatin structure and dynamics]