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Trim21 tripartite motif-containing 21 [ Mus musculus (house mouse) ]

Gene ID: 20821, updated on 17-Jul-2024

Summary

Official Symbol
Trim21provided by MGI
Official Full Name
tripartite motif-containing 21provided by MGI
Primary source
MGI:MGI:106657
See related
Ensembl:ENSMUSG00000030966 AllianceGenome:MGI:106657
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ro52; Ssa1
Summary
Predicted to enable several functions, including protein homodimerization activity; transcription coactivator activity; and ubiquitin protein ligase activity. Involved in positive regulation of viral entry into host cell. Located in cytoplasm. Is expressed in central nervous system; genitourinary system; retina; and thymus primordium. Orthologous to human TRIM21 (tripartite motif containing 21). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 5.4), bladder adult (RPKM 4.4) and 27 other tissues See more
Orthologs
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Genomic context

See Trim21 in Genome Data Viewer
Location:
7 E3; 7 54.76 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (102207127..102214689, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (102557920..102565482, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 52 subfamily B member 4I Neighboring gene olfactory receptor family 52 subfamily B member 3 Neighboring gene STARR-positive B cell enhancer mm9_chr7:109713863-109714163 Neighboring gene predicted gene 5339 Neighboring gene olfactory receptor family 51 subfamily R member 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein deubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of viral transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of viral entry into host cell IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K27-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K6-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein destabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in pyroptotic inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein localization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of viral entry into host cell IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to type II interferon ISO
Inferred from Sequence Orthology
more info
 
involved_in stress granule disassembly ISO
Inferred from Sequence Orthology
more info
 
involved_in suppression of viral release by host ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase TRIM21
Names
52 kDa Ro protein
52 kDa ribonucleoprotein autoantigen Ro/SS-A
52kD Ro/SSA autoantigen
RING-type E3 ubiquitin transferase TRIM21
SS-A
Sjogren syndrome antigen A1
ro(SS-A)
sjoegren syndrome type A antigen
tripartite motif protein 21
tripartite motif-containing protein 21
NP_001076021.1
NP_033303.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082552.2NP_001076021.1  E3 ubiquitin-protein ligase TRIM21

    See identical proteins and their annotated locations for NP_001076021.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' non-coding region, hence, has a shorter 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK150484, AK152619, BB681113, CJ051157
    Consensus CDS
    CCDS40051.1
    UniProtKB/TrEMBL
    Q3U7K7, Q3UCL2
    Related
    ENSMUSP00000102526.2, ENSMUST00000106913.3
    Conserved Domains (4) summary
    cd00021
    Location:86124
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd00162
    Location:1154
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam13094
    Location:181265
    CENP-Q; CENP-Q, a CENPA-CAD centromere complex subunit
    cd12900
    Location:283460
    SPRY_PRY_TRIM21; PRY/SPRY domain in tripartite motif-binding protein 21 (TRIM21) also known as 52kD Ribonucleoprotein Autoantigen (Ro52)
  2. NM_009277.4NP_033303.3  E3 ubiquitin-protein ligase TRIM21

    See identical proteins and their annotated locations for NP_033303.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK171489, BB681113, CJ051157
    Consensus CDS
    CCDS40051.1
    UniProtKB/TrEMBL
    Q3U7K7, Q3UCL2
    Related
    ENSMUSP00000033264.5, ENSMUST00000033264.12
    Conserved Domains (4) summary
    cd00021
    Location:86124
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd00162
    Location:1154
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam13094
    Location:181265
    CENP-Q; CENP-Q, a CENPA-CAD centromere complex subunit
    cd12900
    Location:283460
    SPRY_PRY_TRIM21; PRY/SPRY domain in tripartite motif-binding protein 21 (TRIM21) also known as 52kD Ribonucleoprotein Autoantigen (Ro52)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    102207127..102214689 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)