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Ghsr growth hormone secretagogue receptor [ Mus musculus (house mouse) ]

Gene ID: 208188, updated on 8-Jul-2024

Summary

Official Symbol
Ghsrprovided by MGI
Official Full Name
growth hormone secretagogue receptorprovided by MGI
Primary source
MGI:MGI:2441906
See related
Ensembl:ENSMUSG00000051136 AllianceGenome:MGI:2441906
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GHRP; GHS-R; Ghsr1a; C530020I22Rik
Summary
Predicted to enable G protein-coupled receptor activity; identical protein binding activity; and peptide hormone binding activity. Involved in adult feeding behavior and positive regulation of appetite. Acts upstream of or within several processes, including cellular response to insulin stimulus; growth hormone secretion; and positive regulation of insulin-like growth factor receptor signaling pathway. Predicted to be located in cell surface; membrane raft; and neuron projection. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system gland; and trachea. Human ortholog(s) of this gene implicated in obesity. Orthologous to human GHSR (growth hormone secretagogue receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Ghsr in Genome Data Viewer
Location:
3 A3; 3 10.86 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (27425500..27433384)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (27371351..27379235)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_07234 Neighboring gene predicted gene, 42192 Neighboring gene glycine cleavage system protein H (aminomethyl carrier) pseudogene Neighboring gene tumor necrosis factor (ligand) superfamily, member 10 Neighboring gene STARR-seq mESC enhancer starr_07235 Neighboring gene STARR-seq mESC enhancer starr_07236 Neighboring gene fibronectin type III domain containing 3B Neighboring gene STARR-seq mESC enhancer starr_07237 Neighboring gene predicted gene, 32738 Neighboring gene STARR-positive B cell enhancer ABC_E7905 Neighboring gene microRNA 3092

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (12)  1 citation

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables growth hormone secretagogue receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables growth hormone secretagogue receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables growth hormone-releasing hormone receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables hormone binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables peptide hormone binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in actin polymerization or depolymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in adult feeding behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to insulin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in decidualization ISO
Inferred from Sequence Orthology
more info
 
involved_in ghrelin secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within growth hormone secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in hormone-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in hormone-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of insulin-like growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in learning or memory ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of appetite ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in negative regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of locomotion involved in locomotory behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of macrophage apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of norepinephrine secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of appetite IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of eating behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of growth ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of insulin-like growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of small intestinal transit ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of small intestine smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in postsynaptic modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of feeding behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of gastric motility ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of growth hormone secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of hindgut contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of postsynapse organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of synapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transmission of nerve impulse ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to food IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to hormone ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in synaptic membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
growth hormone secretagogue receptor type 1
Names
G-protein coupled receptor
GH-releasing peptide receptor
ghrelin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177330.4NP_796304.1  growth hormone secretagogue receptor type 1

    See identical proteins and their annotated locations for NP_796304.1

    Status: VALIDATED

    Source sequence(s)
    AC116585
    Consensus CDS
    CCDS17273.1
    UniProtKB/Swiss-Prot
    Q8BWX8, Q91Z82, Q99P50
    UniProtKB/TrEMBL
    Q0VBE5
    Related
    ENSMUSP00000061153.2, ENSMUST00000057186.2
    Conserved Domains (1) summary
    cd15131
    Location:44332
    7tmA_GHSR; growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    27425500..27433384
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319513.2XP_017175002.1  growth hormone secretagogue receptor type 1 isoform X1

    Conserved Domains (1) summary
    cd15131
    Location:107395
    7tmA_GHSR; growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors