U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dhx37 DEAH (Asp-Glu-Ala-His) box polypeptide 37 [ Mus musculus (house mouse) ]

Gene ID: 208144, updated on 8-Nov-2022

Summary

Official Symbol
Dhx37provided by MGI
Official Full Name
DEAH (Asp-Glu-Ala-His) box polypeptide 37provided by MGI
Primary source
MGI:MGI:3028576
See related
Ensembl:ENSMUSG00000029480 AllianceGenome:MGI:3028576
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm451; Gm1050; mKIAA1517
Summary
Predicted to enable U3 snoRNA binding activity. Predicted to be involved in brain development; positive regulation of male gonad development; and ribosome biogenesis. Predicted to be located in cytoplasm and nuclear membrane. Predicted to be active in nucleolus. Human ortholog(s) of this gene implicated in 46,XY sex reversal. Orthologous to human DHX37 (DEAH-box helicase 37). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 9.3), adrenal adult (RPKM 9.1) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Dhx37 in Genome Data Viewer
Location:
5; 5 G1.1
Exon count:
28
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (125490811..125511203, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (125413747..125434139, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA aspartic acid 14 (anticodon GTC) Neighboring gene nuclear encoded tRNA alanine 5 (anticodon TGC) Neighboring gene Bri3 binding protein Neighboring gene predicted gene, 40325

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1517, MGC90028

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables U3 snoRNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in brain development ISO
Inferred from Sequence Orthology
more info
 
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of male gonad development ISO
Inferred from Sequence Orthology
more info
 
involved_in ribosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in ribosome biogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
probable ATP-dependent RNA helicase DHX37
NP_976064.1
XP_017176254.1
XP_030110171.1
XP_036020844.1
XP_036020845.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_203319.1NP_976064.1  probable ATP-dependent RNA helicase DHX37

    See identical proteins and their annotated locations for NP_976064.1

    Status: PROVISIONAL

    Source sequence(s)
    BC066077
    Consensus CDS
    CCDS19685.1
    UniProtKB/TrEMBL
    Q6NZL1
    Related
    ENSMUSP00000131734.2, ENSMUST00000169485.6
    Conserved Domains (6) summary
    smart00490
    Location:578667
    HELICc; helicase superfamily c-terminal domain
    smart00847
    Location:761852
    HA2; Helicase associated domain (HA2) Add an annotation
    COG1643
    Location:2361009
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    cd00046
    Location:267407
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam04408
    Location:730781
    HA2; Helicase associated domain (HA2)
    pfam07717
    Location:8871004
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    125490811..125511203 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320765.2XP_017176254.1  probable ATP-dependent RNA helicase DHX37 isoform X1

    Conserved Domains (1) summary
    COG1643
    Location:2361009
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
  2. XM_030254311.2XP_030110171.1  probable ATP-dependent RNA helicase DHX37 isoform X2

    Conserved Domains (1) summary
    COG1643
    Location:1607
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
  3. XM_036164952.1XP_036020845.1  probable ATP-dependent RNA helicase DHX37 isoform X4

    Conserved Domains (1) summary
    COG1643
    Location:74503
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
  4. XM_036164951.1XP_036020844.1  probable ATP-dependent RNA helicase DHX37 isoform X3

    Conserved Domains (1) summary
    COG1643
    Location:74503
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

RNA

  1. XR_003955608.1 RNA Sequence