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Chmp6 charged multivesicular body protein 6 [ Mus musculus (house mouse) ]

Gene ID: 208092, updated on 5-Jan-2023

Summary

Official Symbol
Chmp6provided by MGI
Official Full Name
charged multivesicular body protein 6provided by MGI
Primary source
MGI:MGI:3583942
See related
Ensembl:ENSMUSG00000025371 AllianceGenome:MGI:3583942
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2400004G01Rik
Summary
Predicted to enable protein N-terminus binding activity. Predicted to be involved in several processes, including midbody abscission; regulation of protein metabolic process; and viral budding via host ESCRT complex. Predicted to act upstream of or within protein transport. Predicted to be located in endosome membrane. Predicted to be part of ESCRT III complex. Predicted to be active in multivesicular body. Orthologous to human CHMP6 (charged multivesicular body protein 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 60.2), colon adult (RPKM 43.9) and 28 other tissues See more
Orthologs
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Genomic context

See Chmp6 in Genome Data Viewer
Location:
11; 11 E2
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (119803874..119810378)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (119913409..119919552)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11762 Neighboring gene regulatory associated protein of MTOR, complex 1 Neighboring gene regulatory associated protein of MTOR, complex 1, opposite strand Neighboring gene predicted gene, 39485 Neighboring gene uncharacterized LOC118567883 Neighboring gene predicted gene 11767 Neighboring gene brain-specific angiogenesis inhibitor 1-associated protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in autophagosome maturation ISO
Inferred from Sequence Orthology
more info
 
involved_in autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in late endosome to lysosome transport ISO
Inferred from Sequence Orthology
more info
 
involved_in late endosome to vacuole transport via multivesicular body sorting pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in membrane fission NAS
Non-traceable Author Statement
more info
PubMed 
involved_in midbody abscission ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic metaphase plate congression ISO
Inferred from Sequence Orthology
more info
 
involved_in multivesicular body assembly NAS
Non-traceable Author Statement
more info
PubMed 
involved_in multivesicular body sorting pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in multivesicular body-lysosome fusion NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of epidermal growth factor-activated receptor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in nuclear membrane reassembly ISO
Inferred from Sequence Orthology
more info
 
involved_in nucleus organization ISO
Inferred from Sequence Orthology
more info
 
involved_in plasma membrane repair ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in vacuolar transport IEA
Inferred from Electronic Annotation
more info
 
involved_in vesicle budding from membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vesicle fusion with vacuole NAS
Non-traceable Author Statement
more info
PubMed 
involved_in viral budding from plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in viral budding via host ESCRT complex ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of ESCRT III complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of ESCRT III complex ISO
Inferred from Sequence Orthology
more info
 
located_in amphisome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in autophagosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
is_active_in multivesicular body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in multivesicular body membrane ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear pore ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
charged multivesicular body protein 6
Names
chromatin modifying protein 6
novel SNF7 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085498.2NP_001078967.1  charged multivesicular body protein 6

    See identical proteins and their annotated locations for NP_001078967.1

    Status: VALIDATED

    Source sequence(s)
    BB870252, BC027085, BG078687, BY463843
    Consensus CDS
    CCDS36385.1
    UniProtKB/Swiss-Prot
    P0C0A3
    UniProtKB/TrEMBL
    A0A6P5QQ22, B1AZ39
    Related
    ENSMUSP00000026434.7, ENSMUST00000026434.13
    Conserved Domains (1) summary
    pfam03357
    Location:18177
    Snf7

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    119803874..119810378
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532718.4XP_006532781.1  charged multivesicular body protein 6 isoform X1

    Conserved Domains (1) summary
    cl21588
    Location:191
    Snf7