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Esrp1 epithelial splicing regulatory protein 1 [ Mus musculus (house mouse) ]

Gene ID: 207920, updated on 5-Jan-2023

Summary

Official Symbol
Esrp1provided by MGI
Official Full Name
epithelial splicing regulatory protein 1provided by MGI
Primary source
MGI:MGI:1917326
See related
Ensembl:ENSMUSG00000040728 AllianceGenome:MGI:1917326
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rbm35a; A630065D16; 2210008M09Rik
Summary
Predicted to enable mRNA binding activity. Involved in regulation of RNA splicing and regulation of inner ear auditory receptor cell fate specification. Acts upstream of or within alternative mRNA splicing, via spliceosome; morphogenesis of a branching epithelium; and positive regulation of epithelial cell proliferation. Predicted to be located in nuclear body. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm. Is expressed in several structures, including alimentary system; branchial arch; extraembryonic component; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 109. Orthologous to human ESRP1 (epithelial splicing regulatory protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 18.2), large intestine adult (RPKM 15.6) and 14 other tissues See more
Orthologs
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Genomic context

See Esrp1 in Genome Data Viewer
Location:
4; 4 A1
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (11331933..11386783, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (11331933..11386783, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene cyclin E2 Neighboring gene integrator complex subunit 8 Neighboring gene dpy-19-like 4 (C. elegans) Neighboring gene ES cell cis-regulatory motif 9a Neighboring gene predicted gene, 35631

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC25805

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
epithelial splicing regulatory protein 1
Names
RNA binding motif protein 35A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290383.1NP_001277312.1  epithelial splicing regulatory protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001277312.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter by an amino acid, compared to isoform 1.
    Source sequence(s)
    AA647208, AK140848, CJ081693, DV648780, DV654302, DV657411
    UniProtKB/Swiss-Prot
    Q3US41, Q8K0G2
    Conserved Domains (6) summary
    COG0724
    Location:284472
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12736
    Location:220304
    RRM1_ESRP1; RNA recognition motif 1 in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
    cd12739
    Location:309417
    RRM2_ESRP1; RNA recognition motif 2 in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
    cd12742
    Location:443523
    RRM3_ESRP1_ESRP2; RNA recognition motif in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins
    cl10012
    Location:29145
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
    cl17169
    Location:633671
    RRM_SF; RNA recognition motif (RRM) superfamily
  2. NM_001347052.1NP_001333981.1  epithelial splicing regulatory protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction in the 3' end and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL772170
    Consensus CDS
    CCDS84703.1
    UniProtKB/Swiss-Prot
    Q3US41
    Related
    ENSMUSP00000103949.2, ENSMUST00000108313.8
  3. NM_194055.3NP_918944.2  epithelial splicing regulatory protein 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA647208, AK042164, AK140848, CJ081693, DV648780, DV657411
    Consensus CDS
    CCDS51119.1
    UniProtKB/Swiss-Prot
    Q3US41
    UniProtKB/TrEMBL
    F8WGU3
    Related
    ENSMUSP00000103947.3, ENSMUST00000108311.9
    Conserved Domains (6) summary
    COG0724
    Location:285473
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12736
    Location:221305
    RRM1_ESRP1; RNA recognition motif 1 in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
    cd12739
    Location:310418
    RRM2_ESRP1; RNA recognition motif 2 in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
    cd12742
    Location:444524
    RRM3_ESRP1_ESRP2; RNA recognition motif in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins
    cl10012
    Location:29145
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
    cl17169
    Location:634672
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    11331933..11386783 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537715.1XP_006537778.1  epithelial splicing regulatory protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3US41
    Related
    ENSMUSP00000103946.2, ENSMUST00000108310.8
    Conserved Domains (6) summary
    cd12736
    Location:221305
    RRM1_ESRP1; RNA recognition motif 1 in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
    cd12739
    Location:310418
    RRM2_ESRP1; RNA recognition motif 2 in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
    cd12742
    Location:444524
    RRM3_ESRP1_ESRP2; RNA recognition motif in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins
    pfam16072
    Location:556631
    DUF4813; Domain of unknown function (DUF4813)
    cl10012
    Location:29145
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
    cl17169
    Location:630668
    RRM_SF; RNA recognition motif (RRM) superfamily
  2. XM_006537718.1XP_006537781.1  epithelial splicing regulatory protein 1 isoform X4

    UniProtKB/Swiss-Prot
    Q3US41
    Conserved Domains (4) summary
    cd12736
    Location:221305
    RRM1_ESRP1; RNA recognition motif 1 in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
    cd12739
    Location:310418
    RRM2_ESRP1; RNA recognition motif 2 in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
    cd12742
    Location:444524
    RRM3_ESRP1_ESRP2; RNA recognition motif in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins
    cl10012
    Location:29145
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
  3. XM_006537717.1XP_006537780.1  epithelial splicing regulatory protein 1 isoform X3

    Conserved Domains (4) summary
    cd12736
    Location:221305
    RRM1_ESRP1; RNA recognition motif 1 in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
    cd12739
    Location:310418
    RRM2_ESRP1; RNA recognition motif 2 in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
    cd12742
    Location:444524
    RRM3_ESRP1_ESRP2; RNA recognition motif in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins
    cl10012
    Location:29145
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
  4. XM_006537716.1XP_006537779.1  epithelial splicing regulatory protein 1 isoform X2

    Related
    ENSMUSP00000037921.8, ENSMUST00000043781.14
    Conserved Domains (6) summary
    cd12736
    Location:221305
    RRM1_ESRP1; RNA recognition motif 1 in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
    cd12739
    Location:310418
    RRM2_ESRP1; RNA recognition motif 2 in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
    cd12742
    Location:444524
    RRM3_ESRP1_ESRP2; RNA recognition motif in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins
    pfam04625
    Location:541632
    DEC-1_N; DEC-1 protein, N-terminal region
    cl10012
    Location:29145
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
    cl17169
    Location:634661
    RRM_SF; RNA recognition motif (RRM) superfamily

RNA

  1. XR_003954898.1 RNA Sequence