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Srebf1 sterol regulatory element binding transcription factor 1 [ Mus musculus (house mouse) ]

Gene ID: 20787, updated on 2-Oct-2018

Summary

Official Symbol
Srebf1provided by MGI
Official Full Name
sterol regulatory element binding transcription factor 1provided by MGI
Primary source
MGI:MGI:107606
See related
Ensembl:ENSMUSG00000020538 Vega:OTTMUSG00000005809
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ADD1; SREBP1; bHLHd1
Summary
This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. Alternatively spliced transcript variants have been characterized for this gene. [provided by RefSeq, Nov 2017]
Expression
Broad expression in mammary gland adult (RPKM 175.8), adrenal adult (RPKM 151.4) and 25 other tissues See more
Orthologs

Genomic context

See Srebf1 in Genome Data Viewer
Location:
11; 11 B2
Exon count:
23
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (60199084..60222686, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (60012591..60034106, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 9 Neighboring gene RAS, dexamethasone-induced 1 Neighboring gene phosphatidylethanolamine N-methyltransferase Neighboring gene predicted gene, 38498 Neighboring gene retinoic acid induced 1 Neighboring gene microRNA 6921 Neighboring gene microRNA 6922 Neighboring gene target of myb1-like 2 (chicken) Neighboring gene predicted gene, 38501 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

  • AMPK signaling pathway, organism-specific biosystem (from KEGG)
    AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • AMPK signaling pathway, conserved biosystem (from KEGG)
    AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • Activation of gene expression by SREBF (SREBP), organism-specific biosystem (from REACTOME)
    Activation of gene expression by SREBF (SREBP), organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Adipogenesis genes, organism-specific biosystem (from WikiPathways)
    Adipogenesis genes, organism-specific biosystemThe different classes of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compos...
  • Circadian Clock, organism-specific biosystem (from REACTOME)
    Circadian Clock, organism-specific biosystemAt the center of the mouse circadian clock is a negative transcription/translation-based feedback loop: The Bmal1:Clock/Npas2 (Arntl:Clock/Npas2) heterodimer transactivates Cryptochrome (Cry) and Per...
  • Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, organism-specific biosystem (from WikiPathways)
    Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Id Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Id Signaling Pathway, organism-specific biosystemInhibitor of DNA binding (ID) proteins are members of the helix-loop-helix (HLH) family of proteins which lack a DNA binding domain themselves but bind to other family members inhibiting their DNA bi...
  • Insulin resistance, organism-specific biosystem (from KEGG)
    Insulin resistance, organism-specific biosystemInsulin resistance is a condition where cells become resistant to the effects of insulin. It is often found in people with health disorders, including obesity, type 2 diabetes mellitus, non-alcoholic...
  • Insulin signaling pathway, organism-specific biosystem (from KEGG)
    Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
  • Insulin signaling pathway, conserved biosystem (from KEGG)
    Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Mus musculus biological processes, organism-specific biosystem (from REACTOME)
    Mus musculus biological processes, organism-specific biosystemCertain mouse pathways have been fully manually curated in Reactome in order to support the manual inference of well-conserved but less well-studied human pathways. These pathways include Circadian...
  • Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystem (from KEGG)
    Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
  • Non-alcoholic fatty liver disease (NAFLD), conserved biosystem (from KEGG)
    Non-alcoholic fatty liver disease (NAFLD), conserved biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
  • Regulation of cholesterol biosynthesis by SREBP (SREBF), organism-specific biosystem (from REACTOME)
    Regulation of cholesterol biosynthesis by SREBP (SREBF), organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Rora activates gene expression, organism-specific biosystem (from REACTOME)
    Rora activates gene expression, organism-specific biosystemRora binds ROR elements (ROREs) in DNA and recruits the coactivators Ppargc1a (Pgc-1alpha) and p300 (Ep300, a histone acetylase) to activate transcription.
  • SREBF and miR33 in cholesterol and lipid homeostasis, organism-specific biosystem (from WikiPathways)
    SREBF and miR33 in cholesterol and lipid homeostasis, organism-specific biosystemThis pathway describes transcription factor-microRNA circuits governing cholesterol and lipid homeostasis. It is based on a seminar by Dr. Anders Näär.
  • White fat cell differentiation, organism-specific biosystem (from WikiPathways)
    White fat cell differentiation, organism-specific biosystemThe transcription factors involved in white fat cell differentiation are shown, specifically their pattern of activity from the preadipocyte to the adipocyte (fat cells) stage. Adipose tissue, compos...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enzyme activator activity IDA
Inferred from Direct Assay
more info
PubMed 
nuclear receptor activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
sterol response element binding ISO
Inferred from Sequence Orthology
more info
 
sterol response element binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cellular response to starvation IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to starvation ISO
Inferred from Sequence Orthology
more info
 
cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
 
circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
lipid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
lipid biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
mRNA transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
macromolecule metabolic process TAS
Traceable Author Statement
more info
PubMed 
negative regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cholesterol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of fatty acid biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
positive regulation of histone deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of pri-miRNA transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of pri-miRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of triglyceride biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of triglyceride biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of autophagy of mitochondrion ISO
Inferred from Sequence Orthology
more info
 
regulation of fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of heart rate by chemical signal IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein stability ISO
Inferred from Sequence Orthology
more info
 
regulation of protein targeting to mitochondrion ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
response to glucose IMP
Inferred from Mutant Phenotype
more info
PubMed 
steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
sterol regulatory element-binding protein 1
Names
adipocyte determination- and differentiation-dependent factor 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313979.1NP_001300908.1  sterol regulatory element-binding protein 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AF374266, BC056922, BY288773
    UniProtKB/Swiss-Prot
    Q9WTN3
    Conserved Domains (2) summary
    cd00083
    Location:310367
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam12497
    Location:114210
    ERbeta_N; Estrogen receptor beta
  2. NM_001358314.1NP_001345243.1  sterol regulatory element-binding protein 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as SREBP-1c) differs in the 5' UTR and 5' coding region compared to variant 1. The encoded isoform (c) has a distinct, shorter N-terminus compared to isoform a.
    Source sequence(s)
    AL669954
    Conserved Domains (3) summary
    cd00083
    Location:291348
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cl25887
    Location:106193
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cl26386
    Location:17198
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  3. NM_001358315.1NP_001345244.1  sterol regulatory element-binding protein 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (d) has a shorter N-terminus than isoform a.
    Source sequence(s)
    AL669954
    Conserved Domains (3) summary
    cd00083
    Location:284341
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cl25887
    Location:99186
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cl26386
    Location:10191
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  4. NM_011480.4NP_035610.1  sterol regulatory element-binding protein 1 isoform a precursor

    See identical proteins and their annotated locations for NP_035610.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as SREBP-1a) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AL669954, BC056922, BY288773
    Consensus CDS
    CCDS24785.1
    UniProtKB/Swiss-Prot
    Q9WTN3
    Related
    ENSMUSP00000020846.1, OTTMUSP00000005985, ENSMUST00000020846.7, OTTMUST00000012870
    Conserved Domains (2) summary
    cd00083
    Location:315372
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam12497
    Location:114210
    ERbeta_N; Estrogen receptor beta

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

    Range
    60199084..60222686 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532717.2XP_006532780.1  sterol regulatory element-binding protein 1 isoform X5

    Conserved Domains (3) summary
    cd00083
    Location:284341
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cl25887
    Location:99186
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cl26386
    Location:10191
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  2. XM_006532716.2XP_006532779.1  sterol regulatory element-binding protein 1 isoform X4

    Related
    ENSMUSP00000122934.1, OTTMUSP00000005986, ENSMUST00000134660.7, OTTMUST00000012871
    Conserved Domains (2) summary
    cd00083
    Location:286343
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam12497
    Location:90186
    ERbeta_N; Estrogen receptor beta
  3. XM_006532715.2XP_006532778.1  sterol regulatory element-binding protein 1 isoform X3

    UniProtKB/Swiss-Prot
    Q9WTN3
    Related
    ENSMUSP00000120777.1, OTTMUSP00000005987, ENSMUST00000144942.1, OTTMUST00000012872
    Conserved Domains (3) summary
    cd00083
    Location:291348
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cl25887
    Location:106193
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cl26386
    Location:17198
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  4. XM_011248845.2XP_011247147.1  sterol regulatory element-binding protein 1 isoform X1

    Conserved Domains (1) summary
    cd00083
    Location:344401
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  5. XM_006532714.3XP_006532777.1  sterol regulatory element-binding protein 1 isoform X2

    Conserved Domains (2) summary
    cd00083
    Location:292349
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam12497
    Location:91187
    ERbeta_N; Estrogen receptor beta
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