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Src Rous sarcoma oncogene [ Mus musculus (house mouse) ]

Gene ID: 20779, updated on 7-Oct-2018

Summary

Official Symbol
Srcprovided by MGI
Official Full Name
Rous sarcoma oncogeneprovided by MGI
Primary source
MGI:MGI:98397
See related
Ensembl:ENSMUSG00000027646 Vega:OTTMUSG00000016179
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AW259666; pp60c-src
Expression
Ubiquitous expression in duodenum adult (RPKM 49.0), colon adult (RPKM 48.4) and 23 other tissues See more
Orthologs

Genomic context

See Src in Genome Data Viewer
Location:
2 H1; 2 78.35 cM
Exon count:
20
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (157423901..157471838)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (157250029..157297574)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39974 Neighboring gene mannosidase, beta A, lysosomal-like Neighboring gene 60S ribosomal protein L35a pseudogene Neighboring gene bladder cancer associated protein Neighboring gene neuronatin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
SH2 domain binding ISO
Inferred from Sequence Orthology
more info
 
cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
 
connexin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
ephrin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
ephrin receptor binding ISO
Inferred from Sequence Orthology
more info
 
estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
 
growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
heme binding ISO
Inferred from Sequence Orthology
more info
 
insulin receptor binding ISO
Inferred from Sequence Orthology
more info
 
ion channel binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
kinase binding ISO
Inferred from Sequence Orthology
more info
 
non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
 
protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase C binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine kinase activity EXP
Inferred from Experiment
more info
PubMed 
protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
scaffold protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
activation of protein kinase B activity ISO
Inferred from Sequence Orthology
more info
 
adherens junction organization ISO
Inferred from Sequence Orthology
more info
 
angiotensin-activated signaling pathway involved in heart process IGI
Inferred from Genetic Interaction
more info
PubMed 
bone resorption IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
bone resorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
branching involved in mammary gland duct morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell proliferation ISO
Inferred from Sequence Orthology
more info
 
cellular response to fluid shear stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to peptide hormone stimulus IGI
Inferred from Genetic Interaction
more info
PubMed 
cellular response to platelet-derived growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to progesterone stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to reactive oxygen species IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to transforming growth factor beta stimulus IGI
Inferred from Genetic Interaction
more info
PubMed 
epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
forebrain development IGI
Inferred from Genetic Interaction
more info
PubMed 
immune system process IEA
Inferred from Electronic Annotation
more info
 
integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
intracellular signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
negative regulation of anoikis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of extrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
negative regulation of intrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of mitochondrial depolarization ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
negative regulation of telomerase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
neurotrophin TRK receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
oogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
osteoclast development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
osteoclast development IGI
Inferred from Genetic Interaction
more info
PubMed 
peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytokine secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glucose metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
positive regulation of lamellipodium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ovarian follicle development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-tyrosine phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of podosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of podosome assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein localization to nucleus IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of protein processing IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein transport ISO
Inferred from Sequence Orthology
more info
 
positive regulation of small GTPase mediated signal transduction ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
primary ovarian follicle growth ISO
Inferred from Sequence Orthology
more info
 
progesterone receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
progesterone receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein destabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of caveolin-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
regulation of cell projection assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
regulation of early endosome to late endosome transport ISO
Inferred from Sequence Orthology
more info
 
regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
 
regulation of intracellular estrogen receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of postsynaptic neurotransmitter receptor activity ISO
Inferred from Sequence Orthology
more info
 
regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
 
stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
substrate adhesion-dependent cell spreading IDA
Inferred from Direct Assay
more info
PubMed 
transcytosis ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
uterus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
actin filament IDA
Inferred from Direct Assay
more info
PubMed 
caveola IDA
Inferred from Direct Assay
more info
PubMed 
caveola ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
extrinsic component of cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
late endosome ISO
Inferred from Sequence Orthology
more info
 
lysosome ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
podosome IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
postsynaptic specialization, intracellular component ISO
Inferred from Sequence Orthology
more info
 
ruffle membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
neuronal proto-oncogene tyrosine-protein kinase Src
Names
p60-Src
proto-oncogene c-Src
NP_001020566.1
NP_033297.2
XP_006499126.1
XP_006499128.1
XP_006499129.1
XP_011237704.1
XP_011237705.1
XP_011237706.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025395.2NP_001020566.1  neuronal proto-oncogene tyrosine-protein kinase Src isoform 2

    See identical proteins and their annotated locations for NP_001020566.1

    Status: VALIDATED

    Source sequence(s)
    AL672259, CD355175, CX218263, M17031
    Consensus CDS
    CCDS16978.1
    UniProtKB/Swiss-Prot
    P05480
    UniProtKB/TrEMBL
    F8WI90
    Related
    ENSMUSP00000029175.7, OTTMUSP00000017316, ENSMUST00000029175.13, OTTMUST00000038724
    Conserved Domains (3) summary
    cd10365
    Location:146246
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:87142
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:259535
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
  2. NM_009271.3NP_033297.2  neuronal proto-oncogene tyrosine-protein kinase Src isoform 1

    See identical proteins and their annotated locations for NP_033297.2

    Status: VALIDATED

    Source sequence(s)
    AL672259, CD355175, CX218263, M17031
    Consensus CDS
    CCDS38305.1
    UniProtKB/Swiss-Prot
    P05480
    Related
    ENSMUSP00000090237.4, ENSMUST00000092576.10
    Conserved Domains (4) summary
    cd10365
    Location:152252
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:87148
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:265541
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
    pfam07714
    Location:275524
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

    Range
    157423901..157471838
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239404.1XP_011237706.1  neuronal proto-oncogene tyrosine-protein kinase Src isoform X1

    See identical proteins and their annotated locations for XP_011237706.1

    Conserved Domains (4) summary
    cd10365
    Location:163263
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:87159
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:276552
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
    pfam07714
    Location:286535
    Pkinase_Tyr; Protein tyrosine kinase
  2. XM_006499066.2XP_006499129.1  neuronal proto-oncogene tyrosine-protein kinase Src isoform X1

    See identical proteins and their annotated locations for XP_006499129.1

    Conserved Domains (4) summary
    cd10365
    Location:163263
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:87159
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:276552
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
    pfam07714
    Location:286535
    Pkinase_Tyr; Protein tyrosine kinase
  3. XM_011239402.2XP_011237704.1  neuronal proto-oncogene tyrosine-protein kinase Src isoform X1

    See identical proteins and their annotated locations for XP_011237704.1

    Conserved Domains (4) summary
    cd10365
    Location:163263
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:87159
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:276552
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
    pfam07714
    Location:286535
    Pkinase_Tyr; Protein tyrosine kinase
  4. XM_011239403.2XP_011237705.1  neuronal proto-oncogene tyrosine-protein kinase Src isoform X1

    See identical proteins and their annotated locations for XP_011237705.1

    Conserved Domains (4) summary
    cd10365
    Location:163263
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:87159
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:276552
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
    pfam07714
    Location:286535
    Pkinase_Tyr; Protein tyrosine kinase
  5. XM_006499063.3XP_006499126.1  neuronal proto-oncogene tyrosine-protein kinase Src isoform X1

    See identical proteins and their annotated locations for XP_006499126.1

    Conserved Domains (4) summary
    cd10365
    Location:163263
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:87159
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:276552
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
    pfam07714
    Location:286535
    Pkinase_Tyr; Protein tyrosine kinase
  6. XM_006499065.3XP_006499128.1  neuronal proto-oncogene tyrosine-protein kinase Src isoform X1

    See identical proteins and their annotated locations for XP_006499128.1

    Conserved Domains (4) summary
    cd10365
    Location:163263
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:87159
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:276552
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
    pfam07714
    Location:286535
    Pkinase_Tyr; Protein tyrosine kinase
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