Scarb1 scavenger receptor class B, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Scarb1provided by MGI
Official Full Name: scavenger receptor class B, member 1provided by MGI
Primary source: MGI:MGI:893578
See related: Ensembl:ENSMUSG00000037936 AllianceGenome:MGI:893578
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CD36; Cla1; SRBI; Srb1; Cla-1; Hdlq1; SR-B1; SR-BI; Cd36l1; Chohd1; Hlb398; mSR-BI; D5Ertd460e
Summary: Enables amyloid-beta binding activity; apolipoprotein binding activity; and high-density lipoprotein particle binding activity. Involved in several processes, including lipid homeostasis; lipid transport; and regulation of lipid metabolic process. Acts upstream of or within several processes, including blood vessel endothelial cell migration; cholesterol catabolic process; and endothelial cell proliferation. Located in caveola; cell surface; and cytoplasm. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; extraembryonic component; hemolymphoid system gland; and reproductive system. Orthologous to human SCARB1 (scavenger receptor class B member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in adrenal adult (RPKM 762.6), ovary adult (RPKM 288.2) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 64.11 cM; 5 G1.1

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (125354151..125418082, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (125277087..125341094, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Serum opacity factor normalizes erythrocyte morphology in Scarb1[-/-] mice in an HDL-free cholesterol-dependent way.
Title: Serum opacity factor normalizes erythrocyte morphology in Scarb1(-/-) mice in an HDL-free cholesterol-dependent way.
Scavenger receptor BI attenuates oxidized phospholipid-induced pulmonary inflammation.
Title: Scavenger receptor BI attenuates oxidized phospholipid-induced pulmonary inflammation.
Serum opacity factor rescues fertility among female Scarb1[-/-] mice by reducing HDL-free cholesterol bioavailability.
Title: Serum opacity factor rescues fertility among female Scarb1(-/-) mice by reducing HDL-free cholesterol bioavailability.
Liver RBFOX2 regulates cholesterol homeostasis via Scarb1 alternative splicing in mice.
Title: Liver RBFOX2 regulates cholesterol homeostasis via Scarb1 alternative splicing in mice.
CircRNA CTNNB1 (circCTNNB1) ameliorates cerebral ischemia/reperfusion injury by sponging miR-96-5p to up-regulate scavenger receptor class B type 1 (SRB1) expression.
Title: CircRNA CTNNB1 (circCTNNB1) ameliorates cerebral ischemia/reperfusion injury by sponging miR-96-5p to up-regulate scavenger receptor class B type 1 (SRB1) expression.
Rosmarinic Acid Exhibits a Lipid-Lowering Effect by Modulating the Expression of Reverse Cholesterol Transporters and Lipid Metabolism in High-Fat Diet-Fed Mice.
Title: Rosmarinic Acid Exhibits a Lipid-Lowering Effect by Modulating the Expression of Reverse Cholesterol Transporters and Lipid Metabolism in High-Fat Diet-Fed Mice.
Hormone-sensitive lipase deficiency affects the expression of SR-BI, LDLr, and ABCA1 receptors/transporters involved in cellular cholesterol uptake and efflux and disturbs fertility in mouse testis.
Title: Hormone-sensitive lipase deficiency affects the expression of SR-BI, LDLr, and ABCA1 receptors/transporters involved in cellular cholesterol uptake and efflux and disturbs fertility in mouse testis.
Class A1 scavenger receptor prevents obesity-associated blood pressure elevation through suppressing overproduction of vascular endothelial growth factor B in macrophages.
Title: Class A1 scavenger receptor prevents obesity-associated blood pressure elevation through suppressing overproduction of vascular endothelial growth factor B in macrophages.
Pcpe2, a Novel Extracellular Matrix Protein, Regulates Adipocyte SR-BI-Mediated High-Density Lipoprotein Uptake.
Title: Pcpe2, a Novel Extracellular Matrix Protein, Regulates Adipocyte SR-BI-Mediated High-Density Lipoprotein Uptake.
High Free Cholesterol Bioavailability Drives the Tissue Pathologies in Scarb1(-/-) Mice.
Title: High Free Cholesterol Bioavailability Drives the Tissue Pathologies in Scarb1(-/-) Mice.

Submit: New GeneRIF Correction See all GeneRIFs (219)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation
QTL (4) 1 citation
Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (3)

General gene information

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Markers

D5Ertd460e (e-PCR), detects polymorphism
- UniSTS:167438

Scarb1 (e-PCR), detects polymorphism
- UniSTS:464690

RH135905 (e-PCR)
- UniSTS:209903

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables amyloid-beta binding	IGI Inferred from Genetic Interaction more info	PubMed
enables apolipoprotein A-I binding	ISO Inferred from Sequence Orthology more info
enables apolipoprotein binding	IPI Inferred from Physical Interaction more info	PubMed
enables apolipoprotein binding	ISO Inferred from Sequence Orthology more info
enables high-density lipoprotein particle binding	IDA Inferred from Direct Assay more info	PubMed
enables high-density lipoprotein particle receptor activity	ISO Inferred from Sequence Orthology more info
enables high-density lipoprotein particle receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipopolysaccharide binding	ISO Inferred from Sequence Orthology more info
enables lipopolysaccharide immune receptor activity	ISO Inferred from Sequence Orthology more info
enables low-density lipoprotein particle binding	IBA Inferred from Biological aspect of Ancestor more info
enables low-density lipoprotein particle binding	ISO Inferred from Sequence Orthology more info
enables low-density lipoprotein particle binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables phosphatidylserine binding	ISO Inferred from Sequence Orthology more info
enables scavenger receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in adhesion of symbiont to host	ISO Inferred from Sequence Orthology more info
involved_in androgen biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood vessel endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cholesterol catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cholesterol catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cholesterol efflux	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol efflux	IDA Inferred from Direct Assay more info	PubMed
involved_in cholesterol efflux	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in cholesterol homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cholesterol import	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol import	IDA Inferred from Direct Assay more info	PubMed
involved_in cholesterol import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cholesterol import	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cholesterol transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cholesterol transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of lipopolysaccharide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endothelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in high-density lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
involved_in high-density lipoprotein particle clearance	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in high-density lipoprotein particle remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intestinal lipid absorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid transport	ISO Inferred from Sequence Orthology more info
involved_in lipopolysaccharide transport	ISO Inferred from Sequence Orthology more info
involved_in low-density lipoprotein particle clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phagocytosis, recognition	ISO Inferred from Sequence Orthology more info
involved_in phospholipid transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plasma lipoprotein particle clearance	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cholesterol storage	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cholesterol storage	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of nitric-oxide synthase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of triglyceride biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in recognition of apoptotic cell	IBA Inferred from Biological aspect of Ancestor more info
involved_in recognition of apoptotic cell	ISO Inferred from Sequence Orthology more info
involved_in recognition of apoptotic cell	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of phosphatidylcholine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reverse cholesterol transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in triglyceride homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vitamin transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in caveola	IBA Inferred from Biological aspect of Ancestor more info
located_in caveola	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in microvillus membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: scavenger receptor class B member 1

Names: HDL QTL 1; scavenger receptor class B type I; scavenger receptor class B1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001205082.2 → NP_001192011.1 scavenger receptor class B member 1 isoform 2

See identical proteins and their annotated locations for NP_001192011.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks the penultimate exon compared to variant 1. This results in a frame-shift, and a shorter isoform (2) with a distinct C-terminus compared to isoform 1.

Source sequence(s)

AC162802

Consensus CDS

CCDS57383.1

UniProtKB/Swiss-Prot

Q61009

Related

ENSMUSP00000107021.2, ENSMUST00000111390.8

Conserved Domains (1) summary

pfam01130
Location:26 → 447

CD36; CD36 family
NM_001205083.2 → NP_001192012.1 scavenger receptor class B member 1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs at the 3' end compared to variant 1. This results in a frame-shift and a longer isoform (3) with a distinct C-terminus compared to isoform 1.

Source sequence(s)

AC162802

Related

ENSMUST00000148373.8

Conserved Domains (1) summary

pfam01130
Location:26 → 447

CD36; CD36 family
NM_001424492.1 → NP_001411421.1 scavenger receptor class B member 1 isoform 4

Status: VALIDATED

Source sequence(s)

AC162802
NM_001424493.1 → NP_001411422.1 scavenger receptor class B member 1 isoform 5

Status: VALIDATED

Source sequence(s)

AC162802
NM_001424494.1 → NP_001411423.1 scavenger receptor class B member 1 isoform 6

Status: VALIDATED

Source sequence(s)

AC162802
NM_001424495.1 → NP_001411424.1 scavenger receptor class B member 1 isoform 7

Status: VALIDATED

Source sequence(s)

AC162802
NM_001424496.1 → NP_001411425.1 scavenger receptor class B member 1 isoform 8

Status: VALIDATED

Source sequence(s)

AC162802
NM_001424497.1 → NP_001411426.1 scavenger receptor class B member 1 isoform 9

Status: VALIDATED

Source sequence(s)

AC162802
NM_016741.3 → NP_058021.1 scavenger receptor class B member 1 isoform 1

See identical proteins and their annotated locations for NP_058021.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1.

Source sequence(s)

AC162802

Consensus CDS

CCDS19683.1

UniProtKB/Swiss-Prot

D3Z2V4, Q3TZ42, Q4FK30, Q61009, Q9CWJ7

Related

ENSMUSP00000083242.7, ENSMUST00000086075.13

Conserved Domains (1) summary

pfam01130
Location:26 → 447

CD36; CD36 family

RNA

NR_188757.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC162802
NR_188758.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC162802

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

125354151..125418082 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036164950.1 → XP_036020843.1 scavenger receptor class B member 1 isoform X2

Conserved Domains (1) summary

pfam01130
Location:11 → 416

CD36; CD36 family
XM_030254308.1 → XP_030110168.1 scavenger receptor class B member 1 isoform X3

Conserved Domains (1) summary

pfam01130
Location:1 → 393

CD36; CD36 family
XM_017320764.2 → XP_017176253.1 scavenger receptor class B member 1 isoform X1

Conserved Domains (1) summary

pfam01130
Location:11 → 416

CD36; CD36 family
XM_030254309.2 → XP_030110169.1 scavenger receptor class B member 1 isoform X3

Conserved Domains (1) summary

pfam01130
Location:1 → 393

CD36; CD36 family