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Pde2a phosphodiesterase 2A, cGMP-stimulated [ Mus musculus (house mouse) ]

Gene ID: 207728, updated on 3-Jan-2019

Summary

Official Symbol
Pde2aprovided by MGI
Official Full Name
phosphodiesterase 2A, cGMP-stimulatedprovided by MGI
Primary source
MGI:MGI:2446107
See related
Ensembl:ENSMUSG00000030653 Ensembl:ENSMUSG00000110195
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
cGSPDE; CGS-PDE
Expression
Broad expression in adrenal adult (RPKM 43.4), cortex adult (RPKM 43.1) and 24 other tissues See more
Orthologs

Genomic context

See Pde2a in Genome Data Viewer
Location:
7; 7 E2
Exon count:
37
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (101421691..101512829)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (108570212..108661341)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene predicted gene 45620 Neighboring gene predicted gene, 35219 Neighboring gene ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 Neighboring gene microRNA 139 Neighboring gene predicted gene, 35363 Neighboring gene uncharacterized LOC102638993 Neighboring gene ADP-ribosyltransferase 2a, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC102210

Gene Ontology Provided by MGI

Function Evidence Code Pubs
3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
3',5'-cyclic-AMP phosphodiesterase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
3',5'-cyclic-AMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
 
3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
3',5'-cyclic-GMP phosphodiesterase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
3',5'-cyclic-GMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
 
3',5'-cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
 
GAF domain binding IDA
Inferred from Direct Assay
more info
PubMed 
TPR domain binding ISO
Inferred from Sequence Orthology
more info
 
cAMP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cAMP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
cAMP binding ISO
Inferred from Sequence Orthology
more info
 
cGMP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cGMP binding IDA
Inferred from Direct Assay
more info
PubMed 
cGMP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
cGMP binding ISO
Inferred from Sequence Orthology
more info
 
cGMP-stimulated cyclic-nucleotide phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cGMP-stimulated cyclic-nucleotide phosphodiesterase activity IDA
Inferred from Direct Assay
more info
PubMed 
cGMP-stimulated cyclic-nucleotide phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
 
drug binding ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
phosphate ion binding ISO
Inferred from Sequence Orthology
more info
 
phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
aorta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cAMP-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
cAMP-mediated signaling NAS
Non-traceable Author Statement
more info
PubMed 
cGMP catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cGMP catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
cGMP catabolic process ISO
Inferred from Sequence Orthology
more info
 
cGMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cGMP-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
cGMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
cGMP-mediated signaling NAS
Non-traceable Author Statement
more info
PubMed 
cardiac septum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to 2,3,7,8-tetrachlorodibenzodioxine ISO
Inferred from Sequence Orthology
more info
 
cellular response to cAMP ISO
Inferred from Sequence Orthology
more info
 
cellular response to cGMP ISO
Inferred from Sequence Orthology
more info
 
cellular response to drug ISO
Inferred from Sequence Orthology
more info
 
cellular response to granulocyte macrophage colony-stimulating factor stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to macrophage colony-stimulating factor stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to mechanical stimulus IDA
Inferred from Direct Assay
more info
PubMed 
coronary vasculature development IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment of endothelial barrier ISO
Inferred from Sequence Orthology
more info
 
heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart valve development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cAMP-mediated signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cGMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cGMP-mediated signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of oxidative phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
negative regulation of vascular permeability ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of vascular permeability ISO
Inferred from Sequence Orthology
more info
 
regulation of mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitochondrion organization ISO
Inferred from Sequence Orthology
more info
 
regulation of nitric oxide mediated signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
ventricular septum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
axon IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
hippocampal mossy fiber ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with plasma membrane ISO
Inferred from Sequence Orthology
more info
 
presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
synaptic membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cGMP-dependent 3',5'-cyclic phosphodiesterase
Names
cyclic GMP-stimulated phosphodiesterase
NP_001008548.1
NP_001137320.1
NP_001137321.1
NP_001230686.1
NP_001230687.1
XP_006507586.1
XP_006507587.1
XP_006507588.1
XP_006507589.1
XP_006507590.1
XP_006507591.1
XP_006507592.1
XP_011240020.1
XP_017177562.1
XP_017177563.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008548.4NP_001008548.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A3

    See identical proteins and their annotated locations for NP_001008548.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform, PDE2A3 (see, PMID:19632989) is shorter, compared to isoform 6.
    Source sequence(s)
    AC129609, BC086800, BY275975
    Consensus CDS
    CCDS40043.1
    UniProtKB/TrEMBL
    Q5PR72
    Related
    ENSMUSP00000147847.1, ENSMUST00000211368.1
    Conserved Domains (2) summary
    smart00065
    Location:404553
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:650883
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  2. NM_001143848.2NP_001137320.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform 6

    See identical proteins and their annotated locations for NP_001137320.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform (6).
    Source sequence(s)
    AC129609, AK159012, BY275975
    Consensus CDS
    CCDS52330.1
    UniProtKB/TrEMBL
    Q3TXZ6
    Related
    ENSMUSP00000131553.2, ENSMUST00000163751.9
    Conserved Domains (2) summary
    smart00065
    Location:408557
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:654884
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  3. NM_001143849.2NP_001137321.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A2 precursor

    See identical proteins and their annotated locations for NP_001137321.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents use of an alternate promoter, has a distinct 5' UTR and 5' coding region, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform, PDE2A2 (see PMID:21724846) has a shorter and distinct N-terminus and lacks an internal segment, compared to isoform 6.
    Source sequence(s)
    AC129079, AC129609
    Conserved Domains (2) summary
    smart00065
    Location:397546
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:643876
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  4. NM_001243757.1NP_001230686.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A1

    See identical proteins and their annotated locations for NP_001230686.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and has multiple differences in the coding region, including the use of an alternate start codon, compared to variant 1. The encoded isoform, PDE2A1 (see PMID:19632989) is shorter and has a distinct N-terminus, compared to isoform 6.
    Source sequence(s)
    AC129609, AK158354, BC057029, BY257486
    UniProtKB/TrEMBL
    Q3TYU3
    Related
    ENSMUSP00000081956.8, ENSMUST00000084894.14
    Conserved Domains (2) summary
    smart00065
    Location:385534
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:631864
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  5. NM_001243758.1NP_001230687.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, uses an alternate splice site in the coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (5) is longer and has a distinct N-terminus, compared to isoform 6.
    Source sequence(s)
    AC129079, AC129609, AK158560, BY276284
    Consensus CDS
    CCDS85351.1
    UniProtKB/TrEMBL
    A0A1B0GRJ9, Q3TYK5
    Related
    ENSMUSP00000147553.1, ENSMUST00000209537.1
    Conserved Domains (2) summary
    smart00065
    Location:414563
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:660893
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

RNA

  1. NR_152192.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) has an additional internal exon and uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC129079, AC129609
  2. NR_152193.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) represents use of an alternate promoter and thus has a distinct 5' end, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC129079, AC129609
  3. NR_152194.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) represents use of an alternate promoter and thus has a distinct 5' end, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC129079, AC129609

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

    Range
    101421691..101512829
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507525.3XP_006507588.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X3

    See identical proteins and their annotated locations for XP_006507588.1

    Conserved Domains (2) summary
    smart00065
    Location:389538
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:635868
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  2. XM_006507527.3XP_006507590.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X4

    Conserved Domains (2) summary
    smart00065
    Location:385534
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:631864
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  3. XM_006507524.3XP_006507587.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X2

    Conserved Domains (2) summary
    smart00065
    Location:418567
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:664897
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  4. XM_006507526.3XP_006507589.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X3

    See identical proteins and their annotated locations for XP_006507589.1

    Conserved Domains (2) summary
    smart00065
    Location:389538
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:635868
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  5. XM_017322073.1XP_017177562.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X6

  6. XM_011241718.2XP_011240020.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X3

    See identical proteins and their annotated locations for XP_011240020.1

    Conserved Domains (2) summary
    smart00065
    Location:389538
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:635868
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  7. XM_006507528.3XP_006507591.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X5

    See identical proteins and their annotated locations for XP_006507591.1

    Conserved Domains (2) summary
    smart00065
    Location:268417
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:514747
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  8. XM_017322074.1XP_017177563.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X6

  9. XM_006507529.3XP_006507592.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X5

    See identical proteins and their annotated locations for XP_006507592.1

    Conserved Domains (2) summary
    smart00065
    Location:268417
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:514747
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  10. XM_006507523.3XP_006507586.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1

    Conserved Domains (2) summary
    smart00065
    Location:422571
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:668901
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
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